{"id":1022,"date":"2025-12-12T00:51:42","date_gmt":"2025-12-12T00:51:42","guid":{"rendered":"https:\/\/www.materialstests.com\/?p=1022"},"modified":"2025-12-12T00:52:10","modified_gmt":"2025-12-12T00:52:10","slug":"10-essential-benefits-of-a-reliable-softgel-capsule-hardness-tester","status":"publish","type":"post","link":"https:\/\/www.materialstests.com\/ko\/resources\/10-essential-benefits-of-a-reliable-softgel-capsule-hardness-tester.html","title":{"rendered":"\uc2e0\ub8b0\ud560 \uc218 \uc788\ub294 \uc18c\ud504\ud2b8\uc824 \ucea1\uc290 \uacbd\ub3c4 \uc2dc\ud5d8\uae30\uc758 10\uac00\uc9c0 \ud544\uc218 \uc774\uc810"},"content":{"rendered":"<p class=\"wp-block-paragraph\">\uc18c\ud504\ud2b8\uc824\uc774\ub780 \ubb34\uc5c7\uc778\uac00\uc694?&nbsp;<a href=\"https:\/\/www.materialstests.com\/ko\/resources\/about-gelatin-capsules-and-the-importance-of-its-hardness-testing.html\/\">\ucea1\uc290 \uacbd\ub3c4<\/a>&nbsp;\ud14c\uc2a4\ud130? \uc18c\ud504\ud2b8 \uc824\ub77c\ud2f4 \ucea1\uc290\uc740 \ud3ec\uc7a5 \uc804\uc5d0 \ud0c4\uc131 \ud14c\uc2a4\ud2b8\ub97c \uac70\uccd0\uc57c \ud569\ub2c8\ub2e4. \ubc14\ub85c \uc774\ub54c \ud14c\uc2a4\ud130\uac00 \ud544\uc694\ud558\uba70, \uadf8\uc57c\ub9d0\ub85c \ud3c9\ubc94\ud55c \ud14c\uc2a4\ud130\ub85c\ub294 \ubd80\uc871\ud569\ub2c8\ub2e4.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\ucea1\uc290 \uc81c\uc870\uc5c5\uccb4\ub4e4\uc740 \uc81c\ud488\uc744 \uc18c\ube44\uc790\uc5d0\uac8c \ucd9c\uc2dc\ud558\uae30 \uc804\uc5d0, \uc790\uc0ac \uc81c\ud488\uc774 \uc815\ud574\uc9c4 \uc5c5\uacc4 \ud45c\uc900 \ud488\uc9c8 \uae30\uc900\uc744 \ucda9\uc871\ud588\ub294\uc9c0 \ud655\uc778\ud558\uae30 \uc704\ud574 \uc2e0\ub8b0\ud560 \uc218 \uc788\ub294 \uc18c\ud504\ud2b8\uc824 \ucea1\uc290 \uacbd\ub3c4 \uce21\uc815\uae30\uac00 \ud544\uc694\ud569\ub2c8\ub2e4.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\uc774 \uacb0\uacfc\ub294 \ucea1\uc290\uc774 \ud3ec\uc7a5\ub420 \uc218 \uc788\ub294 \uc2b9\uc778\uc744 \ubc1b\uc558\ub294\uc9c0 \uc5ec\ubd80\ub97c \uc54c\ub824\uc90d\ub2c8\ub2e4. \uc774\ub97c \ud1b5\ud574 \uc81c\uc870\uc0ac\uc5d0 \ucd94\uac00 \ube44\uc6a9\uc744 \ucd08\ub798\ud560 \uc218 \uc788\ub294 \ud3ec\uc7a5 \uacfc\uc815 \uc911\uc758 \ubc18\ubcf5\uc801\uc778 \uc2e4\ud328\ub97c \ubc29\uc9c0\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\uc824\ub85c\ub9c8\ud2b8\ub294 \uc824\ub77c\ud2f4 \ucea1\uc290 \ud14c\uc2a4\ud2b8 \ubd84\uc57c\uc5d0\uc11c \ucd5c\uace0 \uc218\uc900\uc758 \ud488\uc9c8 \uae30\uc900\uc744 \ub2ec\uc131\ud558\ub294 \uac83\uc744 \ubaa9\ud45c\ub85c \ud569\ub2c8\ub2e4<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\uc18c\ud504\ud2b8 \uc824 \ucea1\uc290\uc5d0 \ub300\ud574 \ub354 \uc54c\uc544\ubcf4\uae30<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\ucea1\uc290 \uc81c\ud488\uc5d0 \uc544\uc824\ub77c\ud2f4 \uacbd\ub3c4 \uc2dc\ud5d8\uae30\ub97c \uc0ac\uc6a9\ud558\ub294 \ub370\uc5d0\ub294 \uc815\ud574\uc9c4 \uaddc\uc815\uc774 \uc788\uc2b5\ub2c8\ub2e4. \uc77c\ubc18\uc801\uc73c\ub85c \ud544\uc694\ud55c \uc2dc\ud5d8 \ud69f\uc218\ub294 \ucea1\uc290\uc758 1\ud68c \ud22c\uc5ec\ub7c9\uc5d0 \ub530\ub77c \ub2ec\ub77c\uc9d1\ub2c8\ub2e4. \ud558\uc9c0\ub9cc \uc774 \uc2dc\ud5d8\uae30\ub294 \uadf8 \uc678\uc5d0\ub3c4 \uc5ec\ub7ec \uac00\uc9c0 \uc7a5\uc810\uc744 \uc81c\uacf5\ud558\uba70, \ubcf8 \uae00\uc5d0\uc11c\ub294 \uc774\uc5d0 \ub300\ud574 \uc0b4\ud3b4\ubcf4\uaca0\uc2b5\ub2c8\ub2e4.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\ud558\uc9c0\ub9cc \uba3c\uc800, \uc18c\ud504\ud2b8 \uc824 \ucea1\uc290\uc5d0 \ub300\ud574 \uc54c\uc544\ub450\uc5b4\uc57c \ud560 \uc810\uc774 \uc788\uc2b5\ub2c8\ub2e4. \uc774 \uc81c\ud488\ub4e4\uc740 \uc758\uc57d\ud488, \ubbf8\ub124\ub784 \ubcf4\ucda9\uc81c, \ube44\ud0c0\ubbfc \ub4f1\uc5d0 \ub110\ub9ac \uc0ac\uc6a9\ub429\ub2c8\ub2e4. \ucea1\uc290\uc774\ub098 \ub9c8\uc774\ud06c\ub85c\ucea1\uc290 \ub0b4\ubd80\uc5d0\ub294 \uc720\ud6a8 \uc131\ubd84\uc774 \ub2f4\uaca8 \uc788\uc5b4, \ub2e4\uc591\ud55c \uc678\ubd80 \uc694\uc778\uc73c\ub85c\ubd80\ud130 \uc81c\ud488\uc744 \ubcf4\ud638\ud569\ub2c8\ub2e4.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\uc774 \ud65c\uc131 \uc131\ubd84\ub4e4\uc740 \uc0ac\ub78c\uc774 \ucea1\uc290\uc744 \uc785\uc5d0 \ub123\uc73c\uba74 \ud655\uc0b0, \uc6a9\ud574, \ub179\uc74c \ub610\ub294 \ud30c\uc5f4\uc744 \ud1b5\ud574 \ubc29\ucd9c\ub429\ub2c8\ub2e4. \ud65c\uc131 \uc131\ubd84\uc774 \ubc29\ucd9c\ub418\ub294 \uc18d\ub3c4\ub294 \ucea1\uc290 \ubcbd\uc758 \uac15\ub3c4\uc5d0 \ub530\ub77c \ub2ec\ub77c\uc9d1\ub2c8\ub2e4.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\uc824 \ucea1\uc290 \ub610\ub294 \uc824\ub77c\ud2f4 \ucea1\uc290\uc774\ub77c\uace0\ub3c4 \ubd88\ub9ac\ub294 \uc18c\ud504\ud2b8 \uc824 \ucea1\uc290\uc740 \uc824\ub77c\ud2f4\uc744 \uc81c\uc870\ud558\uae30 \uc704\ud574 \uac00\uacf5\ub41c \ub3d9\ubb3c \ubf08\uc640 \ud53c\ubd80 \ucf5c\ub77c\uac90\uc73c\ub85c \ub9cc\ub4e4\uc5b4\uc9d1\ub2c8\ub2e4. \ub610\ud55c \uc140\ub8f0\ub85c\uc624\uc2a4\ub85c \ub9cc\ub4e0 \ucc44\uc2dd\uc8fc\uc758\uc790\uc6a9 \ub610\ub294 \uc2dd\ubb3c\uc131 \ucea1\uc290\ub3c4 \uc788\ub294\ub370, \uc774\ub294 HPMC(\ud558\uc774\ub4dc\ub85d\uc2dc\ud504\ub85c\ud544 \uba54\ud2f8\uc140\ub8f0\ub85c\uc624\uc2a4)\ub97c \uc8fc\uc131\ubd84\uc73c\ub85c \uc0ac\uc6a9\ud569\ub2c8\ub2e4. \uadf8\ub7ec\ub098 \uc824 \ucea1\uc290\uc744 \uc81c\uc870\ud558\ub294 \uac83\uc774 \ube44\uc6a9 \ud6a8\uc728\uc774 \ub354 \ub192\uae30 \ub54c\ubb38\uc5d0 \ub2e4\ub978 \uc720\ud615\ubcf4\ub2e4 \ub354 \ub110\ub9ac \uc0ac\uc6a9\ub418\uace0 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\uc824\ub77c\ud2f4 \ucea1\uc290\uc5d0\ub294 \uc5f0\uc9c8 \ucea1\uc290\uacfc \uacbd\uc9c8 \ucea1\uc290, \ub450 \uac00\uc9c0 \uc885\ub958\uac00 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\uc5f0\uc9c8 \ucea1\uc290<\/strong>&nbsp;\uc624\uc77c\uc744 \ud568\uc720\ud558\uac70\ub098 \uc624\uc77c\uc5d0 \ud604\ud0c1\ub418\uac70\ub098 \uc6a9\ud574\ub41c \uc720\ud6a8 \uc131\ubd84\uc744 \uc0ac\uc6a9\ud569\ub2c8\ub2e4.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\uacbd\uc9c8 \ucea1\uc290<\/strong>&nbsp;\ubbf8\ub2c8\u30c1\u30e5\u30a2 \uc54c\uc57d\uc774\ub098 \uac74\uc870\ud55c \ubd84\ub9d0 \ud615\ud0dc\uc758 \uc6d0\ub8cc\uac00 \ub4e4\uc5b4 \uc788\uc2b5\ub2c8\ub2e4. \uc774 \ucea1\uc290\uc740 \ub450 \ubd80\ubd84\uc73c\ub85c \uad6c\uc131\ub418\uc5b4 \uc788\ub294\ub370, \ud55c\ucabd\uc5d0\ub294 \uc57d\uc774 \ub4e4\uc5b4 \uc788\uace0 \ub2e4\ub978 \ud55c\ucabd\uc740 \uc9c0\ub984\uc774 \ub354 \ucee4\uc11c \ucea1\uc290\uc744 \ubc00\ubd09\ud558\ub294 \ub69c\uaed1 \uc5ed\ud560\uc744 \ud569\ub2c8\ub2e4.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\uc824\ub85c\ub9c8\ud2b8 \ucea1\uc290\uc5d0 \uad00\ud55c \ubaa8\ub4e0 \uac83&nbsp;<a href=\"https:\/\/www.materialstests.com\/ko\/products\/gelatin-capsule-hardness-tester.html\/\">\uacbd\ub3c4\uacc4<\/a><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\uc824\ub85c\ub9c8\ud2b8(Gelomat)\ub294 \ucea1\uc290 \uacbd\ub3c4\ub97c \uc790\ub3d9\uc73c\ub85c \uce21\uc815\ud558\ub294 \uc7a5\ube44\uc785\ub2c8\ub2e4. \uc774 \uc7a5\ube44\ub294 \uc5f0\uc9c8 \ucea1\uc290\uacfc \uc77c\ubc18 \ucea1\uc290 \ubaa8\ub450\uc5d0 \uc0ac\uc6a9\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uc2dd\uc6a9 \uc824\ub77c\ud2f4, \ud50c\ub77c\uc2a4\ud2f1, \uc824\ub77c\ud2f4 \ucea1\uc290 \ubc0f \uae30\ud0c0 \uc7ac\ub8cc\uc5d0 \ub300\ud55c \uacbd\ub3c4 \uce21\uc815\uc774 \uac00\ub2a5\ud569\ub2c8\ub2e4. \uae30\ubcf8 \ud14c\uc2a4\ud2b8 \ud5e4\ub4dc\uac00 \ud3ec\ud568\ub418\uc5b4 \uc788\uc73c\ub098, \ucd94\uac00 \uc561\uc138\uc11c\ub9ac\ub97c \uc7a5\ucc29\ud558\uc5ec \uc7a5\ube44\ub97c \uc5c5\uadf8\ub808\uc774\ub4dc\ud558\uace0 \ud6a8\uc728\uc131\uc744 \ub192\uc77c \uc218 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Gelomat\uc740 \uc824\ub77c\ud2f4 \ucea1\uc290 \ud14c\uc2a4\ud2b8 \ubd84\uc57c\uc5d0\uc11c \ucd5c\uace0 \uc218\uc900\uc758 \ud488\uc9c8 \uae30\uc900\uc744 \ub2ec\uc131\ud558\ub294 \uac83\uc744 \ubaa9\ud45c\ub85c \ud569\ub2c8\ub2e4. \uc774 \uc7a5\ube44\ub294 \ucd5c\uc2e0 \uc5f0\uad6c\uac1c\ubc1c \uae30\uc220\uacfc \ucd5c\ucca8\ub2e8 \uc2dc\uc2a4\ud15c\uc744 \ud65c\uc6a9\ud558\uc5ec \uac1c\ubc1c\ub418\uc5c8\uc2b5\ub2c8\ub2e4. \uc774 \uc7a5\ube44\uc5d0\ub294 0~2N \ubc0f 0~20N\uc758 \ub2e4\uc591\ud55c \ud558\uc911 \uc6a9\ub7c9\uc744 \uac00\uc9c4 \ud14c\uc2a4\ud2b8 \ud5e4\ub4dc\ub97c \uc7a5\ucc29\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uc791\uc5c5\uc790\ub294 \uc694\uad6c \uc0ac\ud56d\uc5d0 \ub530\ub77c \ud5e4\ub4dc\ub97c \uc120\ud0dd\ud558\uace0 \ud544\uc694\uc5d0 \ub530\ub77c \uad50\uccb4\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\uc2e0\ub8b0\ud560 \uc218 \uc788\ub294 \uc18c\ud504\ud2b8\uc824 \ucea1\uc290 \uacbd\ub3c4 \uce21\uc815\uae30\uc758 \uc8fc\uc694 \uc7a5\uc810<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>1. \ube44\ud30c\uad34\uc801 \ud574\uacb0\ucc45<\/strong><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Gelomat\uc740 \uc5f0\uc9c8 \uc824 \ucea1\uc290\uc758 \uacbd\ub3c4\ub97c \uce21\uc815\ud558\uae30 \uc704\ud55c \ube44\ud30c\uad34\uc801 \uc194\ub8e8\uc158\uc744 \uc81c\uacf5\ud569\ub2c8\ub2e4. \uc5f0\uc9c8 \uc824 \ucea1\uc290\uacfc \uc824\ub77c\ud2f4 \uc678\uc5d0\ub3c4 \uc544\uac00\ub974, \ud398\uc778\ud2b8\ubcfc, \ud50c\ub808\uc774\ub3c4\uc6b0 \ub4f1\uc758 \uc800\ud56d\ub825\uacfc \uacbd\ub3c4\ub97c \uce21\uc815\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \ub514\uc9c0\ud138 \uce21\uc815 \uc2dc\uc2a4\ud15c\uacfc \uc774 \uc7a5\uce58\uc758 \ub3c5\ucc3d\uc801\uc778 \uc124\uacc4\ub294 \uac00\uc7a5 \uc2e0\ub8b0\ud560 \uc218 \uc788\uace0 \ucd5c\uace0 \uc218\uc900\uc758 \uce21\uc815 \uc815\ubc00\ub3c4\ub97c \ubcf4\uc7a5\ud569\ub2c8\ub2e4.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">0~2N \ub610\ub294 0~20N \ubc94\uc704\uc758 \ud45c\uc900 \uce21\uc815 \ud5e4\ub4dc\ub97c \uc0ac\uc6a9\ud558\ub294 \uac83 \uc678\uc5d0\ub3c4, \uc0ac\uc6a9\uc790\ub294 Centrofix \ub610\ub294 Rotofix\ub97c \uc7a5\ucc29\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. Centrofix\ub294 \uc218\ub3d9\uc73c\ub85c \uc791\ub3d9\ud558\ub294 \uc2dc\ud3b8 \uace0\uc815 \uc7a5\uce58\uc785\ub2c8\ub2e4. Rotofix\ub294 \uc790\ub3d9\uc73c\ub85c \uc791\ub3d9\ud558\ub294 \uc704\uce58 \uc870\uc815 \uc7a5\uce58\uc785\ub2c8\ub2e4. \uc0ac\uc6a9\uc790\ub294 \uc18c\ud504\ud2b8\uc6e8\uc5b4\uc758 \ub3c4\uc6c0\uc744 \ubc1b\uc544 \ubc30\uce58 \ud3f4\ub354 \uc0dd\uc131, \ud788\uc2a4\ud1a0\uadf8\ub7a8 \ud655\uc778, \ub370\uc774\ud130 \uc800\uc7a5, \uacb0\uacfc \ubd84\uc11d \ub4f1\uc758 \uae30\ub2a5\uc744 \uc218\ud589\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\uc18c\ud504\ud2b8 \uc824 \ucea1\uc290 \ud14c\uc2a4\ud2b8\uc5d0 \uc65c \uc774\ub807\uac8c \uc2e0\uacbd\uc744 \uc4f0\ub294 \uac78\uae4c\uc694? \ucea1\uc290\ud654 \uacf5\uc815\uc740 \ub9e4\uc6b0 \uc138\uc2ec\ud558\uc9c0\ub9cc, \uadf8 \ud575\uc2ec\uc740 \ud615\ud0dc\uc5d0 \uc788\uc2b5\ub2c8\ub2e4. \uc774 \uacf5\uc815\uc740 \ucea1\uc290\uc774 \uc81c\ub300\ub85c \uc131\ud615\ub418\uc5b4 \ub0b4\uc6a9\ubb3c\uc744 \ub2f4\uc744 \uc218 \uc788\ub3c4\ub85d \ubcf4\uc7a5\ud569\ub2c8\ub2e4. \ucea1\uc290\uc774 \ucd5c\uc885 \ud615\ud0dc\ub97c \uac16\ucd94\uae30 \uc704\ud574 \ud544\uc694\ud55c \ubaa8\ub4e0 \ub2e8\uacc4\ub97c \uac70\uce58\uba74 \ud14c\uc2a4\ud2b8\ub294 \uc644\ub8cc\ub429\ub2c8\ub2e4.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\ub2e4\uc74c\uc740 \uc18c\ud504\ud2b8 \uc824 \ucea1\uc290\uc744 \ub9cc\ub4dc\ub294 \ubc29\ubc95\uc744 \ub2e8\uacc4\ubcc4\ub85c \uc18c\uac1c\ud569\ub2c8\ub2e4:<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\uc9c0\ub984 24\uc778\uce58\uc9dc\ub9ac \uc2a4\ud14c\uc778\ub9ac\uc2a4 \uc2a4\ud2f8 \ub4dc\ub7fc\uc774 \ucc9c\ucc9c\ud788 \ud68c\uc804\ud558\ub294 \uac00\uc6b4\ub370, \ub530\ub73b\ud55c \uc561\uc0c1 \uc824\ub77c\ud2f4\uc774 \ubd80\uc5b4\uc9d1\ub2c8\ub2e4.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\ub4dc\ub7fc\uc740 \ubd84\ub2f9 400\uc785\ubc29\ud53c\ud2b8\uc758 \uc555\ucd95\uae30 \uc720\ub7c9\uc5d0 \ub178\ucd9c\ub418\uba70, \uc774\ub54c \uacf5\uae30 \uc628\ub3c4\ub294 \ud654\uc528 590\ub3c4, \uc0c1\ub300\uc2b5\ub3c4\ub294 20%\uc785\ub2c8\ub2e4.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\ub4dc\ub7fc\uc774 \uacc4\uc18d \ud68c\uc804\ud558\uba74\uc11c, \uc824\ub77c\ud2f4\uc740 \ucc28\uac11\uace0 \uac74\uc870\ud55c \uacf5\uae30\uc5d0 \uc758\ud574 \uad73\uc5b4\uc9c0\ub2e4\uac00, \ud0c4\ub825 \uc788\uace0 \ub048\uc801\ud55c \ub760\uac00 \ubc18\ub300\ucabd \ub05d\uc73c\ub85c \uad74\ub7ec\ub098\uc635\ub2c8\ub2e4.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\uc774 \uc587\uc740 \ub760\uac00 \ucea1\uc290\uc744 \ud615\uc131\ud569\ub2c8\ub2e4. \uc774 \uacfc\uc815\uc740 \uc790\ub3d9\uc73c\ub85c \uc774\ub8e8\uc5b4\uc9d1\ub2c8\ub2e4.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\uc774 \ucea1\uc290\uc5d0\ub294 \ube44\ud0c0\ubbfc, \uc758\uc57d\ud488, \uac74\uac15\uae30\ub2a5\uc2dd\ud488 \ub4f1 \uc81c\uc870\uc0ac\uc758 \uc81c\ud488\ub4e4\uc774 \ub4e4\uc5b4 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\ucc44\uc6cc\uc9c4 \ucea1\uc290\uc740 \ubc00\ubd09\ub41c \ud6c4 \ud2b8\ub808\uc774\uc5d0 \ub5a8\uc5b4\ub728\ub824\uc9d1\ub2c8\ub2e4.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\ucc44\uc6cc\uc9c4 \ucea1\uc290\uc740 \uc544\uc9c1 \ucd95\ucd95\ud558\uace0 \ubd80\ub4dc\ub7ec\uc6b0\ubbc0\ub85c, \ucc54\ubc84\ub098 \uac74\uc870 \ub4dc\ub7fc\uc73c\ub85c \uc62e\uaca8\uc9d1\ub2c8\ub2e4.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\uac74\uc870 \uc2dc\uac04\uc740 \uc218\ubd84\uc744 \uc81c\uac70\ud558\ub294 \ub370 \uac78\ub9ac\ub294 \uc2dc\uac04, \ucea1\uc290\uc758 \uac1c\uc218, \ucea1\uc290\uc758 \ud06c\uae30 \ub4f1 \uc5ec\ub7ec \uc694\uc778\uc5d0 \ub530\ub77c \ub2ec\ub77c\uc9d1\ub2c8\ub2e4.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\uc18c\ud504\ud2b8 \uc824 \ucea1\uc290\uc744 \uc81c\uc870\ud558\ub294 \uacfc\uc815\uc774 \uc774\ud1a0\ub85d \uc138\uc2ec\ud569\ub2c8\ub2e4. \uc8fc\uc785 \uacfc\uc815\uc5d0\uc11c \ub4dc\ub7fc\uc774 \ub178\ucd9c\ub418\ub294 \uacf5\uae30\uc758 \uc628\ub3c4\ub294 \uc824\uc774 \ub108\ubb34 \ubd80\uc11c\uc9c0\uae30 \uc27d\uac8c \ub418\uac70\ub098 \ub108\ubb34 \ube68\ub9ac \uad73\uc5b4\uc9c0\ub294 \uc6d0\uc778\uc774 \ub420 \uc218 \uc788\uc73c\ubbc0\ub85c \ub9e4\uc6b0 \uc911\uc694\ud569\ub2c8\ub2e4. \uc774 \ub450 \uac00\uc9c0 \uacbd\uc6b0 \ubaa8\ub450 \uc0dd\uc0b0\uc774 \uc911\ub2e8\ub418\uace0 \uacf5\uc815\uc744 \ucc98\uc74c\ubd80\ud130 \ub2e4\uc2dc \uc2dc\uc791\ud574\uc57c \ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\uacf5\uae30 \uc720\uc18d\uc774 \ub108\ubb34 \ube60\ub974\uba74 \uc824 \ucea1\uc290\uc758 \ub450\uaed8\uac00 \uc77c\uc815\ud558\uc9c0 \uc54a\uac8c \ub429\ub2c8\ub2e4. \ubc18\ub300\ub85c \uacf5\uae30 \uc720\uc18d\uc774 \ub108\ubb34 \ub290\ub9ac\uace0 \uc2b5\ub3c4 \ubc0f \uae30\uc628\uc774 \ub108\ubb34 \ub192\uc73c\uba74 \uc824\ub77c\ud2f4\uc774 \uad73\uae30 \uc5b4\ub835\uc2b5\ub2c8\ub2e4.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\uac74\uc870 \uacfc\uc815 \uc911\uc5d0\ub294 \uc8fc\ubcc0 \uc628\ub3c4\ub97c \uc9c0\uc18d\uc801\uc73c\ub85c \uc870\uc808\ud574\uc57c \ud569\ub2c8\ub2e4. \uc774\uc0c1\uc801\uc778 \uc2b5\ub3c4 \uc218\uc900\uc740 \uacf5\uae30 1\ud30c\uc6b4\ub4dc\ub2f9 20\uadf8\ub808\uc778\uc774\uba70, \uc774\uc2ac\uc810\uc740 \ud654\uc528 25\ub3c4\uc785\ub2c8\ub2e4.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\ucea1\uc290\uc774 \uc644\uc804\ud788 \uac74\uc870\ub418\uba74 Gelomat\uacfc \uac19\uc740 \uc18c\ud504\ud2b8\uc824 \ucea1\uc290 \uacbd\ub3c4 \uce21\uc815\uae30\ub97c \uc0ac\uc6a9\ud558\uc5ec \uac80\uc0ac\ub97c \uc2e4\uc2dc\ud569\ub2c8\ub2e4. \uc774 \ub2e8\uacc4\uc5d0\uc11c\ub3c4 \ucd5c\uc885\uc801\uc73c\ub85c \uc2dc\uc7a5\uc5d0 \ud310\ub9e4\ub420 \ucea1\uc290\uc758 \uc218\ub7c9\uc740 \uac80\uc0ac \uacb0\uacfc\uc5d0 \ub530\ub77c \uacb0\uc815\ub429\ub2c8\ub2e4. \uc774\ub97c \ud1b5\ud574 \ubcf4\uad00 \uc911\uc778 \uc7ac\uace0\uc758 \ud488\uc9c8\uc744 \ubcf4\uc7a5\ud558\uace0 \uc81c\uc870\uc0ac\uc758 \uba85\uc131\uc5d0 \ud760\uc774 \uac00\uc9c0 \uc54a\ub3c4\ub85d \ud569\ub2c8\ub2e4.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\uc7a5\uce58\uac00 \ub192\uc740 \uc7ac\ud604\uc131\uc744 \uac16\ucd94\ub294 \uac83\uc774 \uc65c \uc911\uc694\ud55c\uac00\uc694? \ucea1\uc290\uc740 \ubc30\uce58 \ub2e8\uc704\ub85c \ud14c\uc2a4\ud2b8\ub418\uba70, \ud55c \ubc30\uce58 \ub0b4\uc758 \ubaa8\ub4e0 \ucea1\uc290\uc740 \uc11c\ub85c \uc720\uc0ac\ud55c \ud2b9\uc131\uacfc \uacbd\ub3c4\ub97c \ubcf4\uc5ec\uc57c \ud569\ub2c8\ub2e4.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>2. \uc774 \ud14c\uc2a4\ud2b8\uae30\ub294 \ub0b4\uad6c\uc131\uacfc \uc815\ud655\uc131\uc744 \uace0\ub824\ud558\uc5ec \uc81c\uc791\ub418\uc5c8\uc2b5\ub2c8\ub2e4.<\/strong><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\uc774 \uc824\ub77c\ud2f4 \uacbd\ub3c4\uacc4\ub294 \ub3c5\uc77c\uc0b0 \uae30\uae30 \uc911 \ucd5c\uace0 \uc218\uc900\uc758 \uc815\ud655\ub3c4\ub97c \uac16\ub3c4\ub85d \uac1c\ubc1c\ub418\uc5c8\uc2b5\ub2c8\ub2e4. \ub610\ud55c \uc7ac\ud604\uc131\uc774 \ub9e4\uc6b0 \ub6f0\uc5b4\ub0a9\ub2c8\ub2e4.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\uc7a5\uce58\uac00 \ub192\uc740 \uc7ac\ud604\uc131\uc744 \uac16\ucd94\ub294 \uac83\uc774 \uc65c \uc911\uc694\ud55c\uac00\uc694? \ucea1\uc290\uc740 \ubc30\uce58 \ub2e8\uc704\ub85c \ud14c\uc2a4\ud2b8\ub418\uba70, \ud55c \ubc30\uce58 \ub0b4\uc758 \ubaa8\ub4e0 \ucea1\uc290\uc740 \uc11c\ub85c \uc720\uc0ac\ud55c \ud2b9\uc131\uacfc \uacbd\ub3c4\ub97c \ubcf4\uc5ec\uc57c \ud569\ub2c8\ub2e4.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\uc18c\ube44\uc790\uac00 \uadf8 \ucc28\uc774\ub97c \uc54c\uc544\ucc28\ub9ac\uace0, \ub354 \ubd80\ub4dc\ub7ec\uc6b4 \uc81c\ud488\uc774 \uc720\ud1b5\uae30\ud55c\uc774 \uc9c0\ub0ac\uac70\ub098 \uac00\uc9dc\ub77c\uace0 \uc0dd\uac01\ud558\uac8c \ub418\ub294 \uc77c\uc740 \uc5c6\uc5b4\uc57c \ud569\ub2c8\ub2e4. \ucea1\uc290\uc774 \uc6d0\ubcf8\uacfc \ub9e4\uc6b0 \uc720\uc0ac\ud558\uac8c \uc7ac\ud604\ub418\uc5c8\uc744 \ub54c\ub9cc \ucd5c\uace0\uc758 \uc2e0\ub8b0\ub3c4\ub97c \ud655\ubcf4\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\uacfc\ud559 \ubd84\uc57c\uc5d0\uc11c \uc7ac\ud604\uc131\uc740 \uc815\ubc00\ub3c4 \uc2dc\ud5d8\uc758 \ub9c8\uc9c0\ub9c9\uc774\uc790 \uc138 \ubc88\uc9f8 \ub2e8\uacc4\uc785\ub2c8\ub2e4. \uc548\uc815\uc131\uc744 \ud655\ubcf4\ud558\uae30 \uc704\ud574 \uc2dc\ud5d8 \ub300\uc0c1 \uc81c\ud488\uc5d0 \ub530\ub77c \ub9c8\ucee4 \uc2dc\uc2a4\ud15c\uc774 \uc120\uc815\ub429\ub2c8\ub2e4. \uc824\ub77c\ud2f4 \ucea1\uc290\uc744 \uc2dc\ud5d8\ud560 \ub54c\ub294 \uac74\uc870 \uac00\uc18c\uc81c\uac00 \uc801\uc808\ud55c \uc911\ub7c9 \ube44\uc728\uc744 \uc774\ub8f9\ub2c8\ub2e4.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\uac74\uc870 \uc824\ub77c\ud2f4\uacfc \ubb3c\uc758 \ube44\uc728\uc740 1:1\uc774\uba70, \uac74\uc870 \uc824\ub77c\ud2f4\uc758 \ube44\uc728\uc740 0.4~0.6:1.0\uc785\ub2c8\ub2e4. \uc774\ub54c \uc911\ub7c9\ube44\uac00 1.8:1\uc774 \ub418\uba74 \uaecd\uc9c8\uc774 \ubd80\ub4dc\ub7ec\uc6b4 \uc0c1\ud0dc\uc784\uc744 \uc758\ubbf8\ud569\ub2c8\ub2e4. \ucea1\uc290\uc774 \uac00\uc7a5 \ub2e8\ub2e8\ud55c \uc0c1\ud0dc\uac00 \ub418\ub824\uba74 \uac00\uc18c\uc81c\uc640 \uc824\ub77c\ud2f4\uc758 \uc911\ub7c9\ube44\uac00 0.3:1.0\uc774\uc5b4\uc57c \ud569\ub2c8\ub2e4.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>3. \ub2e4\uc591\ud55c \uc0b0\uc5c5 \ubd84\uc57c\uc5d0 \uc801\ud569 \u2013 \uc81c\uc57d \uc0b0\uc5c5<\/strong><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\uc815\uc81c \uacbd\ub3c4\uacc4\ub294 \uc8fc\ub85c \uc81c\uc57d \uc0b0\uc5c5\uc5d0\uc11c \uc0ac\uc6a9\ub429\ub2c8\ub2e4. \uc774 \uc2e4\ud5d8\uc2e4 \ud14c\uc2a4\ud2b8\ub97c \ud1b5\ud574 \uc815\uc81c\uc758 \uad6c\uc870\uc801 \uc548\uc815\uc131\uacfc \ud30c\ub2e8\uc810\uc744 \ud655\uc778\ud569\ub2c8\ub2e4. \ub610\ud55c \ucde8\uae09, \ud3ec\uc7a5, \uc6b4\uc1a1 \ubc0f \ubcf4\uad00 \uacfc\uc815\uc5d0\uc11c \uc815\uc81c\uac00 \uc5b4\ub5bb\uac8c \ubcc0\ud654\ud558\ub294\uc9c0\ub3c4 \ud30c\uc545\ud569\ub2c8\ub2e4. \uc815\uc81c\uc758 \ud30c\ub2e8\uc810\uc740 \uadf8 \ud615\ud0dc\uc5d0 \ub530\ub77c \uacb0\uc815\ub429\ub2c8\ub2e4.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\uc774\ub7ec\ud55c \uc885\ub958\uc758 \uc2dc\ud5d8\uae30\ub294 1930\ub144\ub300\ubd80\ud130 \uc874\uc7ac\ud574 \uc654\uc2b5\ub2c8\ub2e4. \ud558\uc9c0\ub9cc 1953\ub144\uc774 \ub418\uc5b4\uc11c\uc57c \ub85c\ubc84\ud2b8 \uc54c\ube0c\ub808\ud788\ud2b8\uac00 \ud2b9\ud5c8\ub97c \ucd9c\uc6d0\ud588\uace0, \u2018\uc2a4\ud2b8\ub871-\ucf65 \uc2dc\ud5d8\uae30\u2019\ub77c\uace0 \uba85\uba85\ub418\uc5c8\uc2b5\ub2c8\ub2e4. \ub2f9\uc2dc\uc5d0\ub294 \uacf5\uae30 \ud38c\ud504\ub85c \uc0ac\uc6a9\ub418\uc5c8\uc2b5\ub2c8\ub2e4.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\uad6c\ud615 \uac80\uc0ac\uae30\uc758 \ubb38\uc81c\uc810\uc740 \uacb0\uacfc\uc758 \uc77c\uad00\uc131\uc774 \ubd80\uc871\ud588\ub2e4\ub294 \uc810\uc785\ub2c8\ub2e4. \uc824\ub85c\ub9c8\ud2b8(Gelomat)\uc640 \uac19\uc740 \uc2e0\ud615 \ubaa8\ub378\ub4e4\uc740 \ubc14\ub85c \uc774 \uc810\uc744 \uac1c\uc120\ud588\uc2b5\ub2c8\ub2e4.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\uc774 \uc798 \uc54c\ub824\uc9c4 \uae30\uae30\uc5d0 \ub2e4\uc74c\uacfc \uac19\uc740 \uae30\ub2a5\uc744 \ud0d1\uc7ac\ud568\uc73c\ub85c\uc368 \uc774\uac83\uc774 \uac00\ub2a5\ud574\uc84c\uc2b5\ub2c8\ub2e4:<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\uc790\ub3d9 \uce21\uc815 \uacf5\uc815\uc758 \uc644\uc804\ud55c \ud1b5\ud569<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\ud788\uc2a4\ud14c\ub9ac\uc2dc\uc2a4 \uae30\ub2a5<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\ub192\uc740 \uac80\uc0ac \ud6a8\uc728\uacfc \ucd5c\uace0 \uc218\uc900\uc758 \uc815\ud655\ub3c4\ub97c \uc81c\uacf5\ud569\ub2c8\ub2e4<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\ub9de\ucda4\ud615 \uace0\uc815 \uc7a5\uce58<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">USB \ud3ec\ud2b8\ub97c \ud1b5\ud55c \ud3b8\ub9ac\ud558\uace0 \ube60\ub978 \ub370\uc774\ud130 \uc804\uc1a1<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\ubc18\ubcf5\uc131\uacfc \ucd5c\uace0 \uc218\uc900\uc758 \uc815\ud655\ub3c4\ub97c \ucda9\uc871\ud558\ub3c4\ub85d \uc124\uacc4\ub41c \uc0ac\uc6a9\uc790 \uce5c\ud654\uc801\uc778 \uc2dc\uc2a4\ud15c<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\uc790\ub3d9 \uc218\uc815 \uae30\ub2a5<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\ub514\uc9c0\ud138 \ub514\uc2a4\ud50c\ub808\uc774\ub294 \uce21\uc815\uac12\uc774 \ud55c\uacc4\uac12\ubcf4\ub2e4 \ub0ae\uac70\ub098 \ub192\uc744 \ub54c \uc774\ub97c \ud45c\uc2dc\ud569\ub2c8\ub2e4<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\uc774 \ub514\uc9c0\ud138 \ub514\uc2a4\ud50c\ub808\uc774 \uc7a5\uce58\ub294 \uc2dc\uac04\uacfc \uac70\ub9ac\ub97c \uce21\uc815\ud558\ub294 \uac83\uc744 \ud3ec\ud568\ud558\uc5ec \ub2e4\uc591\ud55c \uae30\ub2a5\uc744 \uc218\ud589\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>4. \ub2e4\uc591\ud55c \uc0b0\uc5c5 \ubd84\uc57c\uc5d0 \uc801\ud569 \u2013 \ud398\uc778\ud2b8\ubcfc \uc0b0\uc5c5<\/strong><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\ud398\uc778\ud2b8\ubcfc \uc0b0\uc5c5\uc5d0\uc11c \uacbd\ub3c4 \uc2dc\ud5d8\uae30\ub294 \uc5b4\ub5a4 \uc6a9\ub3c4\ub85c \uc0ac\uc6a9\ub420\uae4c\uc694? \ucea1\uc290\uc758 \uacbd\uc6b0\uc640 \ub9c8\ucc2c\uac00\uc9c0\ub85c, \ud398\uc778\ud2b8\ubcfc \uc5ed\uc2dc \ubcfc \uc2dc\uc800, \ubc30\ub7f4, \ub9c8\ucee4\ub97c \ud14c\uc2a4\ud2b8\ud560 \uc218 \uc788\ub294 \uc7ac\ud604\uc131 \uc788\uace0 \uc2e0\ub8b0\ud560 \uc218 \uc788\ub294 \ubc29\ubc95\uc774 \ud544\uc694\ud569\ub2c8\ub2e4. \uc774\ub7ec\ud55c \uc2dc\ud5d8 \uc2dc\uc2a4\ud15c\uc740 \uc815\ud655\uc131, \uc7ac\ud604\uc131, \uadf8\ub9ac\uace0 \uac04\ud3b8\uc131\uc744 \ubcf4\uc7a5\ud574\uc57c \ud569\ub2c8\ub2e4.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\uc774 \uc5c5\uacc4\uc5d0\uc11c\ub294 \ud398\uc778\ud2b8\ubcfc\uc758 \uada4\uc801\uc5d0 \uc601\ud5a5\uc744 \ubbf8\uce58\ub294 \ub3c5\ub9bd \ubcc0\uc218\uc640 \uc885\uc18d \ubcc0\uc218\ub97c \uad6c\ubd84\ud558\uace0 \uba85\ud655\ud788 \uc815\uc758\ud558\ub294 \uac83\uc774 \ub9e4\uc6b0 \uc911\uc694\ud569\ub2c8\ub2e4. \ubcfc\uc758 \uc815\ud655\ub3c4\ub294 \uadf8 \ud488\uc9c8\uc5d0 \ud06c\uac8c \uc88c\uc6b0\ub429\ub2c8\ub2e4. \ubcfc\uc774 \ubd80\ud480\uc5b4 \uc624\ub974\uac70\ub098 \uc774\uc74c\uc0c8\uac00 \ubcf4\uc774\uac70\ub098 \uc6c0\ud479 \ud328\uc778 \ubd80\ubd84\uc774 \uc5c6\uc5b4\uc57c\ub9cc \uc9c1\uc120\uc73c\ub85c \ubc1c\uc0ac\ud560 \uc218 \uc788\ub294\ub370, \ud14c\uc2a4\ud2b8 \ub2f4\ub2f9\uc790\ub294 \uc774\ub7ec\ud55c \uc694\uc18c\ub4e4\uc744 \uaf3c\uaf3c\ud788 \ud655\uc778\ud558\uace0 \ubd88\ub7c9\ud488\uc744 \uac78\ub7ec\ub0c5\ub2c8\ub2e4.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\uacf5\uc758 \ud488\uc9c8 \uc678\uc5d0\ub3c4 \ubc30\ub7f4\uc758 \uacbd\ub3c4 \uc5ed\uc2dc \ub0b4\ubd80 \ub9c8\uac10\uc758 \ub0b4\uad6c\uc131\uc744 \uc88c\uc6b0\ud569\ub2c8\ub2e4. \ub610\ud55c \ubc30\ub7f4\uc758 \uad6c\uba4d\uc740 \uc801\uc808\ud55c \uac01\ub3c4\uc640 \ud06c\uae30\ub97c \uac16\ucdb0\uc57c \ud569\ub2c8\ub2e4. \ucda9\uc804 \ubc29\uc2dd\uc758 \uacbd\uc6b0, \ub9ce\uc740 \uc81c\uc870\uc0ac\ub4e4\uc774 CO2\ubcf4\ub2e4 \uc2e0\ub8b0\uc131\uc774 \ub192\uace0 \uc815\ud655\ub3c4\uac00 \ub354 \ub6f0\uc5b4\ub098\ub2e4\uace0 \ud310\ub2e8\ud558\uc5ec \uc555\ucd95 \uacf5\uae30\ub97c \uc0ac\uc6a9\ud569\ub2c8\ub2e4.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>5. \ub2e4\uc591\ud55c \uc0b0\uc5c5 \ubd84\uc57c\uc5d0 \uc801\ud569 \u2013 \ud654\uc7a5\ud488 \uc0b0\uc5c5<\/strong><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\ud654\uc7a5\ud488 \uc5c5\uacc4\uc5d0\ub294 \uacbd\ub3c4 \uc2dc\ud5d8\uc744 \uac70\uce58\ub294 \uac83\uc774 \uc720\uc775\ud55c \uc81c\ud488\uc774 \ub9ce\uc2b5\ub2c8\ub2e4. \uc608\ub97c \ub4e4\uc5b4, \ud654\uc7a5\ud488 \ud30c\uc6b4\ub370\uc774\uc158\uc740 \uc555\ub825\uc744 \uac00\ud588\uc744 \ub54c \ucda9\ubd84\ud55c \uacbd\ub3c4\ub97c \uc720\uc9c0\ud558\uace0 R&amp;D \ubc0f \ud488\uc9c8 \uad00\ub9ac\uc758 \uc124\uc815\ub41c \uae30\uc900\uc744 \ucda9\uc871\ud558\ub294\uc9c0 \ud655\uc778\ud558\uae30 \uc704\ud574 \uc774 \ud14c\uc2a4\ud2b8\ub97c \uac70\uce69\ub2c8\ub2e4. \uc774\ub294 \uc77c\ubc18\uc801\uc73c\ub85c \uc18c\ud504\ud2b8\uc6e8\uc5b4, \ucf00\uc774\ube14, \ud14c\uc2a4\ud2b8 \uc2a4\ud0e0\ub4dc \ubc0f \ud798 \uce21\uc815\uae30\ub97c \ud65c\uc6a9\ud558\ub294 \ud14c\uc2a4\ud2b8\uae30\ub97c \uc0ac\uc6a9\ud558\uc5ec \uc218\ud589\ub429\ub2c8\ub2e4. \uc774 \ud14c\uc2a4\ud2b8\uae30\ub294 \ubc15\ub9ac\ub825, \uc555\ucd95\ub825, \uc778\uc7a5\ub825 \ub4f1\uc758 \uae30\uacc4\uc801 \ud2b9\uc131\uc744 \uce21\uc815\ud569\ub2c8\ub2e4.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\uc774 \uacbd\ub3c4 \uce21\uc815\uae30\ub294 \ub9bd\uc2a4\ud2f1, \ub208\uc379\u00b7\uc785\uc220\uc6a9 \ud39c, \uc641\uc2a4 \ubc0f \ud06c\ub9bc \uc81c\ud488 \ub4f1 \ud654\uc7a5\ud488\uc758 \ud488\uc9c8\uc744 \ud655\uc778\ud558\ub294 \ub370\uc5d0\ub3c4 \uc0ac\uc6a9\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uc5c5\uacc4\uc5d0\uc11c\ub294 \uacbd\ub3c4\ubcf4\ub2e4 \uc81c\ud488\uc758 \uc9c8\uac10 \ud14c\uc2a4\ud2b8 \uacb0\uacfc\uc5d0 \ub354 \ud070 \ube44\uc911\uc744 \ub461\ub2c8\ub2e4. \ud654\uc7a5\ud488\uc740 \uc2dc\uc7a5\uc5d0 \ucd9c\uc2dc\ud558\uae30 \uc804\uc5d0 \ud53c\ubd80\uc5d0 \ubc14\ub97c \ub54c \uc0ac\uc6a9\uac10\uc774 \uc88b\uc740\uc9c0 \ubc18\ub4dc\uc2dc \ud655\uc778\ud574\uc57c \ud558\uae30 \ub54c\ubb38\uc785\ub2c8\ub2e4.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>6. \uc7ac\ub8cc\uc758 \uc778\uc7a5 \ubc0f \uc555\ucd95 \uac15\ub3c4\ub97c \uc2dc\ud5d8\ud55c\ub2e4<\/strong><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\uc18c\ud504\ud2b8\uc824\uc744 \ud14c\uc2a4\ud2b8\ud560 \ub54c\ub294 \ucea1\uc290 \ubcbd\uc758 \uac15\ub3c4\ub97c \uc815\ub7c9\ud654\ud558\uc5ec \ud30c\uc5f4\uc810\uc744 \ud655\uc778\ud569\ub2c8\ub2e4. \ub610\ud55c \ubc00\ubd09 \ubd80\uc704\uc758 \ucde8\uc57d\uc131\uc774\ub098 \uc824\ub77c\ud2f4 \ub9c9\uc758 \uc0c1\ud0dc\ub97c \ud30c\uc545\ud558\uae30\ub3c4 \ud569\ub2c8\ub2e4. \uc774\ub7ec\ud55c \ud14c\uc2a4\ud2b8\ub294 \ucea1\uc290\uc774 \uc18c\ube44\uc790\uc5d0\uac8c \uc804\ub2ec\ub418\uae30 \uc804\uc5d0 \ud30c\uc5f4\ub420 \uc218 \uc788\ub294 \uc694\uc778\ub4e4\uc744 \uc2dc\ubbac\ub808\uc774\uc158\ud558\uae30 \uc704\ud574 \uc218\ud589\ub429\ub2c8\ub2e4.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\uc824\ub85c\ub9c8\ud2b8\ub294 \ucea1\uc290\uc5d0 \uc555\ub825\uc744 \uac00\ud574 \ud488\uc9c8 \uad00\ub9ac \uae30\uc900\uc744 \ucda9\uc871\ud558\ub294\uc9c0 \uc5ec\ubd80\ub97c \ud655\uc778\ud569\ub2c8\ub2e4. \uc774 \uc7a5\uce58\ub294 \ucea1\uc290\uc774 \uc678\ubd80 \ud798\uc744 \ubc1b\uc558\uc744 \ub54c\ub3c4 \ud615\ud0dc\ub97c \uc720\uc9c0\ud560 \uc218 \uc788\uc744 \ub9cc\ud07c \ubcbd\uba74 \uac15\ub3c4\uac00 \ucda9\ubd84\ud55c\uc9c0 \ud14c\uc2a4\ud2b8\ud569\ub2c8\ub2e4.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\uc774 \uc7a5\uce58\uc758 \ubaa9\uc801\uc740 \ub204\ucd9c\ub41c \ucea1\uc290\uc774 \uc18c\ube44\uc790\uc5d0\uac8c \uc804\ub2ec\ub418\uc9c0 \uc54a\ub3c4\ub85d \ud558\ub294 \uac83\uc785\ub2c8\ub2e4. \uc774\ub97c \ud1b5\ud574 \uc18c\ube44\uc790\uc758 \uc81c\uc870\uc0ac\uc5d0 \ub300\ud55c \uc2e0\ub8b0\ub3c4\uac00 \ub192\uc544\uc9c0\uace0 \uc7ac\uad6c\ub9e4\uc728\ub3c4 \uc99d\uac00\ud558\uac8c \ub429\ub2c8\ub2e4.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\uacbd\ub3c4 \uc2dc\ud5d8\uc740 \ucea1\uc290\uacfc \uac19\uc740 \uc81c\ud488\uc774 \ud488\uc9c8 \uad00\ub9ac\ub97c \uc704\ud574 \uac70\uce58\ub294 \uc218\ub9ce\uc740 \uc2dc\ud5d8 \uc911 \ud558\ub098\uc77c \ubfd0\uc785\ub2c8\ub2e4. \ud398\uc778\ud2b8\ubcfc\uc774\ub098 \ud654\uc7a5\ud488\ub3c4 \ub9c8\ucc2c\uac00\uc9c0\uc785\ub2c8\ub2e4. \uc18c\ube44\uc790\uac00 \uad6c\ub9e4\ud558\uac70\ub098 \uc18c\ube44\ud558\uae30 \uc704\ud574 \ub9cc\ub4e4\uc5b4\uc9c4 \uc774\ub7ec\ud55c \ubaa8\ub4e0 \uc81c\ud488\uc740 \ud3ec\uc7a5\ub418\uc5b4 \ud310\ub9e4\ub418\uae30 \uc804\uc5d0 \uc77c\ub828\uc758 \uc2dc\ud5d8\uc744 \uac70\uce69\ub2c8\ub2e4.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\uc18c\ud504\ud2b8 \uc824 \ucea1\uc290\uc758 \uacbd\uc6b0, \uac01 \uc0dd\uc0b0 \ub85c\ud2b8\ub294 \uad11\uace0\ub41c \ub0b4\uc6a9\uc5d0 \ubd80\ud569\ud558\uace0 \uc12d\ucde8\uc5d0 \uc801\ud569\ud55c\uc9c0 \ud655\uc778\ud558\uae30 \uc704\ud574 \uc77c\ub828\uc758 \uc5c4\uaca9\ud55c \uac80\uc0ac\ub97c \uac70\uce69\ub2c8\ub2e4.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>7. \ucd5c\uc2e0 \uae30\uc220\uc744 \ud65c\uc6a9\ud569\ub2c8\ub2e4<\/strong><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\uad6c\ud615 \ubaa8\ub378\ub4e4\uacfc \ub2ec\ub9ac, \ub3c5\uc77c\uc0b0 \uc824\ub85c\ub9c8\ud2b8(Gelomat)\uc640 \uac19\uc740 \ucd5c\uc2e0 \uacbd\ub3c4 \uce21\uc815\uae30\ub294 \ub6f0\uc5b4\ub09c \uac00\uc131\ube44\uc640 \ud6a8\uc728\uc131, \uadf8\ub9ac\uace0 \ucd5c\uc2e0 \ud2b9\ud5c8 \uae30\uc220\uc744 \ubaa8\ub450 \uac16\ucd94\uace0 \uc788\uc2b5\ub2c8\ub2e4. \uc824\ub85c\ub9c8\ud2b8\ub294 \uc721\ub958 \uacbd\ub3c4 \uce21\uc815\uae30, \ud06c\ub9bc \uacbd\ub3c4 \uce21\uc815\uae30, \ubc84\ud130 \uacbd\ub3c4 \uce21\uc815\uae30 \ub4f1\uc73c\ub85c \ub2e4\uc591\ud558\uac8c \ud65c\uc6a9\ub420 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uc774\ub294 \uc81c\uc870\uc0ac\ub4e4\uc774 \uace0\uac1d\uc5d0\uac8c \ucd5c\uace0\uc758 \uc81c\ud488\uc744 \uc81c\uacf5\ud558\uae30 \uc704\ud574 \uc5bc\ub9c8\ub098 \uc9c4\uc9c0\ud558\uac8c \ub178\ub825\ud558\uace0 \uc788\ub294\uc9c0\ub97c \ubcf4\uc5ec\uc90d\ub2c8\ub2e4.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\uc824\ub85c\ub9c8\ud2b8\ub294 \uc815\ubc00\ud55c \ub514\uc9c0\ud138 \uce21\uc815 \uc2dc\uc2a4\ud15c\uacfc \ub3c5\uc790\uc801\uc778 \uc124\uacc4\ub97c \uc801\uc6a9\ud558\uc5ec, \uc2dc\ud5d8 \uacb0\uacfc\uc758 \uc815\ud655\uc131\uc744 \uc800\ud574\ud558\uc9c0 \uc54a\uc73c\uba74\uc11c\ub3c4 \uacf5\uc815\uc744 \ub354\uc6b1 \uac04\ud3b8\ud558\uac8c \uc218\ud589\ud560 \uc218 \uc788\ub3c4\ub85d \ud569\ub2c8\ub2e4. \uc824\ub77c\ud2f4 \ucea1\uc290\uc740 \ucd5c\uc801\uc758 \uc7ac\ud604\uc131\uacfc \uc815\ud655\ub3c4\ub97c \ubcf4\uc7a5\ud558\ub294 \uc2e0\ub8b0\ud560 \uc218 \uc788\ub294 \uc2dc\uc2a4\ud15c\uc744 \ud1b5\ud574 \uacbd\ub3c4 \uce21\uc815\uc744 \uc790\ub3d9\uc73c\ub85c \uc218\ud589\ud569\ub2c8\ub2e4.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\uc824\ub85c\ub9c8\ud2b8(Gelomat) \uc2dc\uc2a4\ud15c\uc740 \uace0\uac1d\uc758 \uace0\uc720\ud55c \uc2dc\ud5d8 \uc694\uad6c \uc0ac\ud56d\uc744 \ucda9\uc871\ud558\uae30 \uc704\ud574 \ub9de\ucda4\ud615 \uace0\uc815\uad6c\uc640 \uc564\ube4c\uc744 \uac1c\ubc1c\ud568\uc73c\ub85c\uc368 \uc138\uacc4\uc5d0\uc11c\ub3c4 \uc720\ub840\uc5c6\ub294 \uc720\uc5f0\uc131\uc744 \uc81c\uacf5\ud558\ub294 \uba87 \uc548 \ub418\ub294 \uc2dc\uc2a4\ud15c \uc911 \ud558\ub098\uc785\ub2c8\ub2e4. \uc774\ub7ec\ud55c \uc810 \ub355\ubd84\uc5d0 \uc824\ub85c\ub9c8\ud2b8 \uc2dc\uc2a4\ud15c\uc740 \ub3c5\ubcf4\uc801\uc778 \uc194\ub8e8\uc158 \ud328\ud0a4\uc9c0\ub85c \uc790\ub9ac\ub9e4\uae40\ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>8. \uc815\uc81c\uc758 \uacbd\ub3c4\ub97c \ub354 \uc27d\uac8c \uce21\uc815\ud560 \uc218 \uc788\ub3c4\ub85d \ud558\uae30<\/strong><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\uace0\ud615 \uc815\uc81c\ub294 \uc758\uc57d\ud488\uc5d0\uc11c \uac00\uc7a5 \ud754\ud788 \uc0ac\uc6a9\ub418\ub294 \uc81c\ud615\uc785\ub2c8\ub2e4. \uc815\uc81c\uc758 \uacbd\ub3c4\ub294 \uc81c\ud488 \ud488\uc9c8 \uad00\ub9ac \uaddc\uaca9\uacfc \uc81c\ud488 \uac1c\ubc1c \uae30\uc900\uc758 \uc911\uc694\ud55c \uc694\uc18c\uc785\ub2c8\ub2e4.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\uc815\uc81c \uacbd\ub3c4 \uc2dc\ud5d8\uae30\ub294 \uc81c\ud488\uc73c\ub85c\ubd80\ud130 \uc815\ud655\ud55c \uce21\uc815 \uacb0\uacfc\ub97c \uc5bb\uc5b4\uc57c \ud558\uba70, \uc774\ub294 \uac01 \uc815\uc81c\uac00 \ub108\ubb34 \ubd80\ub4dc\ub7fd\uc9c0\ub3c4 \uc54a\uace0 \ub108\ubb34 \ub2e8\ub2e8\ud558\uc9c0\ub3c4 \uc54a\uc544\uc57c \ud568\uc744 \uc758\ubbf8\ud569\ub2c8\ub2e4.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\uc815\uc81c\uac00 \ub108\ubb34 \ubd80\ub4dc\ub7ec\uc6b0\uba74 \ud658\uc790\uac00 \ubcf5\uc6a9\ud55c \ud6c4 \uc870\uae30\uc5d0 \ubd84\ud574\ub420 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uc774\ub294 \uacb0\ud569\ub825\uc774 \uc57d\ud558\uae30 \ub54c\ubb38\uc77c \uc218 \uc788\uc2b5\ub2c8\ub2e4. \ub610\ud55c, \ub108\ubb34 \ubd80\ub4dc\ub7ec\uc6b4 \uc815\uc81c\ub294 \ud3ec\uc7a5, \ucf54\ud305 \ubc0f \uae30\ud0c0 \uc81c\uc870 \uacf5\uc815 \uc911\uc5d0 \ubd80\uc11c\uc9c0\uac70\ub098 \uae4e\uc5ec \ub098\uac08 \uc218 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\ubc18\uba74, \uc815\uc81c\uac00 \uc9c0\ub098\uce58\uac8c \ub2e8\ub2e8\ud558\uba74 \ud658\uc790\uac00 \ubcf5\uc6a9\ud588\uc744 \ub54c \uc801\uc815 \uc6a9\ub7c9\uc774 \uc81c\ub300\ub85c \uc6a9\ud574\ub418\uc9c0 \uc54a\uc744 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uc774 \ubb38\uc81c\ub294 \ubd80\ud615\uc81c\uc640 \uc720\ud6a8 \uc131\ubd84 \uac04\uc758 \uacb0\ud569\ub825\uc774 \uc9c0\ub098\uce58\uac8c \uac15\ud558\uae30 \ub54c\ubb38\uc77c \uc218 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\uc815\uc81c\uc758 \uacbd\ub3c4\ub97c \uce21\uc815\ud558\uba74 \ud574\ub2f9 \uc81c\ud488\uc774 \ubcf5\uc6a9 \uac00\ub2a5\ud558\uace0 \ucd5c\uace0 \uc218\uc900\uc758 \ud488\uc9c8 \uae30\uc900\uc744 \ucda9\uc871\ud558\ub294\uc9c0 \uc815\ub7c9\uc801\uc73c\ub85c \ud655\uc778\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uadf8\ub7ec\ub098 \ucd5c\uc801\uc758 \uacb0\uacfc\ub97c \uc5bb\uae30 \uc704\ud574\uc11c\ub294 \ud544\uc694\ud55c \ubaa8\ub4e0 \uae30\uacc4\uc801 \ud2b9\uc131\uc744 \uac16\ucd94\uace0 \uc788\uc5b4\uc57c \ud569\ub2c8\ub2e4. \uc81c\uc870\uc0ac\ub294 \uc81c\ud488\uc5d0 \uc801\uc808\ud55c \uc131\ubd84 \ubc30\ud569\uc774 \uc801\uc6a9\ub418\uc5c8\ub294\uc9c0, \uc720\ud6a8 \uc131\ubd84\uc758 \ud2b9\uc131 \ubc0f \uc0ac\uc6a9\ub41c \uacb0\ud569\uc81c\uac00 \uc801\uc808\ud55c\uc9c0 \ud655\uc778\ud574\uc57c \ud569\ub2c8\ub2e4. \ucd5c\uc885 \uc815\uc81c\uac00 \uacbd\ub3c4 \uc2dc\ud5d8\uc744 \ud1b5\uacfc\ud560 \uac00\ub2a5\uc131\uc744 \ub192\uc774\uae30 \uc704\ud574, \uc81c\uc870 \uacfc\uc815 \uc911\uc5d0\ub3c4 \uc774\ub7ec\ud55c \uc694\uc18c\ub4e4\uc744 \ucca0\uc800\ud788 \uad00\ub9ac\ud574\uc57c \ud569\ub2c8\ub2e4.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>9. \ucd5c\uc2e0 \uc5c5\uacc4 \ud45c\uc900\uc744 \ucca0\uc800\ud788 \uc900\uc218\ud569\ub2c8\ub2e4<\/strong><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\uc824\ub77c\ud2f4 \ucea1\uc290\uc758 \uacbd\uc6b0, \uc644\uc81c\ud488\uc740 \ubc18\ub4dc\uc2dc \uac80\uc0ac\ub97c \uac70\uccd0\uc57c \ud569\ub2c8\ub2e4. \uc774\ubbf8 \u2018\ucea1\uc290 \uacbd\ub3c4 \uce21\uc815\uae30\u2019\ub098 \u2018\uc824\ub77c\ud2f4 \uacbd\ub3c4 \uce21\uc815\uae30\u2019\uc640 \uac19\uc740 \uc6a9\uc5b4\ub97c \ub4e4\uc5b4\ubcf4\uc168\uc744 \uc218\ub3c4 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\uc774 \ucea1\uc290\ub4e4\uc740 \uaddc\uc81c \uc694\uac74 \ubc0f \uc57d\uc804 \uae30\uc900\uc744 \ucda9\uc871\ud558\uae30 \uc704\ud574 \uc5ec\ub7ec \ucc28\ub840\uc758 \uac80\uc0ac\ub97c \uac70\uce69\ub2c8\ub2e4. \uac80\uc0ac \uacb0\uacfc\uc5d0 \ub530\ub77c \ud574\ub2f9 \ubc30\uce58 \uc81c\ud488\uc774 \uc758\ub3c4\ub41c \uc6a9\ub3c4\uc640 \uc2dc\ud310\uc5d0 \uc801\ud569\ud55c\uc9c0 \uc5ec\ubd80\uac00 \uacb0\uc815\ub429\ub2c8\ub2e4.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>10. \ub300\uc911\uc758 \uc2e0\ub8b0\ub97c \uc5bb\ub294\ub2e4<\/strong><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\uc774\ub7ec\ud55c \uac80\uc0ac\uac00 \uc65c \ud544\uc694\ud55c\uac00\uc694? \uc774 \uc81c\ud488\ub4e4\uc740 \uc18c\ube44\uc790\uc758 \uc2e0\ub8b0\uc5d0 \ud06c\uac8c \uc758\uc874\ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4. \ucea1\uc290\uc5d0\uc11c \ub0b4\uc6a9\ubb3c\uc774 \uc0c8\uc5b4 \ub098\uc624\uba74 \ud574\ub2f9 \uc81c\ud488\ubfd0\ub9cc \uc544\ub2c8\ub77c \uac19\uc740 \uc81c\uc870\uc0ac\uc758 \ub2e4\ub978 \ubaa8\ub4e0 \uc81c\ud488\uc5d0 \ub300\ud55c \uc18c\ube44\uc790\uc758 \uc778\uc2dd\uc5d0\ub3c4 \ubd80\uc815\uc801\uc778 \uc601\ud5a5\uc744 \ubbf8\uce60 \uc218 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\uc774 \ub54c\ubb38\uc5d0 \uacb0\ud568\uc774 \uc788\ub294 \ucea1\uc290\uc774 \uc2dc\uc7a5\uc5d0 \uc720\ud1b5\ub418\uc9c0 \uc54a\ub3c4\ub85d \ud558\ub294 \uac83\uc774 \ub9e4\uc6b0 \uc911\uc694\ud569\ub2c8\ub2e4. \ub530\ub77c\uc11c \uc81c\uc870\uc0ac\ub4e4\uc740 \uc18c\ud504\ud2b8\uc824 \ucea1\uc290 \uacbd\ub3c4 \uce21\uc815\uae30\ub97c \uc0ac\uc6a9\ud558\uc5ec \uc2dc\uc7a5\uc5d0 \ucd9c\uc2dc\ud560 \ubaa8\ub4e0 \uc81c\ud488\uc774 \uc790\uc0ac\uc758 \uba85\uc131\uc5d0 \ud760\uc9d1\uc774 \ub098\uc9c0 \uc54a\ub3c4\ub85d \ucca0\uc800\ud788 \uad00\ub9ac\ud569\ub2c8\ub2e4.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\ucd5c\uc885 \uc0dd\uac01<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\uc18c\ud504\ud2b8\uc824 \uacbd\ub3c4 \uce21\uc815\uae30\ub97c \ud65c\uc6a9\ud558\uba74 \uadc0\uc0ac\uc758 \ud488\uc9c8 \uad00\ub9ac \ubd80\uc11c\uc5d0\uc11c \ub9ce\uc740 \uc774\uc810\uc744 \uc5bb\uc744 \uc218 \uc788\uc9c0\ub9cc, \uac80\uc99d\ub41c \uace0\ud488\uc9c8 \uc7a5\ube44\uc5d0 \uc758\uc874\ud574\uc57c \ud569\ub2c8\ub2e4. \ubc14\ub85c \uc774\uac83\uc774 1954\ub144 \ucc3d\ub9bd \uc774\ub798 \uae30\uc220\uacfc \ud601\uc2e0\uc5d0 \uc804\ub150\ud574 \uc628 \ubc14\ub77c\uc774\uc2a4(Bareiss)\uac00 \uc798 \uc54c\ub824\uc9c4 \uc774\uc720\uc785\ub2c8\ub2e4.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\ud14c\uc2a4\ud2b8: \ucea1\uc290\uc758 \ubc00\ud3d0\uc131\uc740 \uc5b4\ub290 \uc815\ub3c4\uc778\uac00\uc694?<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\uc824\ub77c\ud2f4 \ucea1\uc290\uc5d0\uc11c \ub0b4\uc6a9\ubb3c\uc774 \uc0c8\uba74 \uc18c\ube44\uc790\ub4e4\uc774 \uc81c\ud488\uacfc \uc81c\uc870\uc0ac\uc5d0 \ub300\ud55c \uc2e0\ub8b0\ub97c \uc783\uac8c \ub429\ub2c8\ub2e4. \uacb0\ud568\uc774 \uc788\ub294 \ucea1\uc290\uc774 \uc2dc\uc7a5\uc5d0 \uc720\ud1b5\ub418\ub294 \uac83\uc744 \ubc29\uc9c0\ud558\ub824\uba74, \uc774\ub97c \uc2dd\ubcc4\ud560 \uc218 \uc788\ub294 \uac80\uc0ac \ubc29\ubc95\uc744 \uac1c\ubc1c\ud574\uc57c \ud569\ub2c8\ub2e4. \ud55c \uac00\uc9c0 \ubc29\ubc95\uc740 \uc824\ub77c\ud2f4 \ucea1\uc290\uc5d0 \uc778\uc7a5\ub825\uacfc \uc555\ucd95\ub825\uc744 \uac00\ud574, \uc81c\uc870, \ubcf4\uad00, \ud3ec\uc7a5 \ubc0f \uc6b4\uc1a1 \uacfc\uc815\uc5d0\uc11c \ubc1c\uc0dd\ud558\ub294 \uc678\ubd80 \ud798\uc744 \uacac\ub51c \uc218 \uc788\uc744 \ub9cc\ud07c \ucda9\ubd84\ud55c \ubcbd\uba74 \uac15\ub3c4\ub97c \uac16\ucd94\uace0 \uc788\ub294\uc9c0 \ud655\uc778\ud558\ub294 \ud14d\uc2a4\ucc98 \ubd84\uc11d\uae30\ub97c \uc0ac\uc6a9\ud558\ub294 \uac83\uc785\ub2c8\ub2e4.&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\ucea1\uc290 \uc81c\uc81c\ub97c \uc81c\uc870\ud560 \ub54c\ub294, \uc6d0\ub8cc\uc758\uc57d\ud488(API)\uacfc \ubd80\ud615\uc81c\ub97c \ud3ec\ud568\ud55c \ucda9\uc804\ubb3c\uc774 \uc218\uc6a9\uc131 \ub2e8\ubc31\uc9c8\uc758 \ud63c\ud569\ubb3c\ub85c \uc774\ub8e8\uc5b4\uc9c4 \uc824\ub77c\ud2f4 \uaecd\uc9c8\uacfc \ud638\ud658\ub418\ub294\uc9c0 \uc5ec\ubd80\ub97c \ud30c\uc545\ud558\ub294 \uac83\uc774 \uc911\uc694\ud569\ub2c8\ub2e4. \uc54c\ub370\ud788\ub4dc(\uc608: \ud3ec\ub984\uc54c\ub370\ud788\ub4dc)\ub97c \ud568\uc720\ud55c \ubb3c\uc9c8\uc740 \uc824\ub77c\ud2f4 \ub0b4 \ubc0f \uc824\ub77c\ud2f4 \uac00\ub2e5 \uc0ac\uc774\uc758 \ub77c\uc774\uc2e0 \uc794\uae30\uc640\uc758 \uac00\uad50 \ubc18\uc751\uc744 \uc720\ubc1c\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uc774\ub85c \uc778\ud574 \uc824\ub77c\ud2f4 \uad6c\uc870\uac00 \uacbd\ud654\ub418\uc5b4 \ubd84\ud574 \uc18d\ub3c4\uac00 \ub290\ub824\uc9d1\ub2c8\ub2e4. \ucda9\uc804\ubb3c\uc774 \uc824\ub77c\ud2f4 \ucea1\uc290\uc758 \uc218\ubd84 \ud568\ub7c9\uacfc \uc5b4\ub5bb\uac8c \uc0c1\ud638\uc791\uc6a9\ud558\ub294\uc9c0\ub97c \ud30c\uc545\ud558\ub294 \uac83\ub3c4 \uc911\uc694\ud569\ub2c8\ub2e4. \uc608\ub97c \ub4e4\uc5b4, \ud761\uc2b5\uc131\uc774 \ub9e4\uc6b0 \ub192\uc740 \ucda9\uc804\ubb3c\uc740 \ucea1\uc290\uc758 \uc218\ubd84\uc744 \ud761\uc218\ud558\uc5ec \ucea1\uc290\uc744 \ucde8\uc131 \uc788\uac8c \ub9cc\ub4e4\uace0 \ud30c\uc190\ub418\uae30 \uc27d\uac8c \ub9cc\ub4e4 \uc218 \uc788\uc2b5\ub2c8\ub2e4.&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\uc9c8\uac10 \ubd84\uc11d\uae30\ub294 \uacbd\uc9c8\uc758 \uae30\uacc4\uc801 \uac15\ub3c4\ub97c \uc815\ub7c9\ud654\ud569\ub2c8\ub2e4&nbsp;<a href=\"https:\/\/www.materialstests.com\/ko\/resources\/about-gelatin-capsules-and-the-importance-of-its-hardness-testing.html\/\">\uc824\ub77c\ud2f4 \ucea1\uc290<\/a>&nbsp;\ucea1\uc290\uc758 \uac15\ub3c4\uc640 \uc548\uc815\uc131\uc5d0 \ub2e4\uc591\ud55c \ucda9\uc804\uc7ac\uac00 \uc5b4\ub5a4 \uc601\ud5a5\uc744 \ubbf8\uce58\ub294\uc9c0 \ud3c9\uac00\ud560 \uc218 \uc788\ub3c4\ub85d \ucea1\uc290 \uc2dc\ub8cc\ub97c \uc900\ube44\ud569\ub2c8\ub2e4. \uc774\ub294 \uc2dc\ub8cc\uc5d0 \uc81c\uc5b4\ub41c \uae30\uacc4\uc801 \uc870\uac74\uc744 \uac00\ud55c \ud6c4, \uadf8 \uacb0\uacfc\ub85c \ub098\ud0c0\ub098\ub294 \uac70\ub3d9\uc744 \uc815\ub7c9\ud654\ud568\uc73c\ub85c\uc368 \uc774\ub8e8\uc5b4\uc9d1\ub2c8\ub2e4. \uc2dc\ub8cc\uac00 \uc5b4\ub5bb\uac8c \ubc18\uc751\ud558\ub294\uc9c0\ub294 \uc2dc\ub8cc\uc758 \ubb3c\ub9ac\uc801 \ud2b9\uc131\uacfc \uc9c1\uc811\uc801\uc778 \uad00\ub828\uc774 \uc788\uc73c\uba70, \uc2dc\ub8cc\uc758 \ub0b4\ubd80 \uad6c\uc870\uc5d0 \ub300\ud55c \uc2e4\uc81c\uc801\uc778 \uc815\ubcf4\ub97c \uc81c\uacf5\ud569\ub2c8\ub2e4.&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\uacb0 c\u1ea5u \ubd84\uc11d\uae30\ub294 \uc778\uc7a5 \ub610\ub294 \uc555\ucd95 \ubaa8\ub4dc\ub85c \uc791\ub3d9\ud558\uba70, \ubcc0\ud615 \uc791\uc6a9\uc744 \uc5ec\ub7ec \ubc88 \uac00\ud558\ub294 \uc8fc\uae30\uc801 \uc2dc\ud5d8\uc744 \uc218\ud589\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uc774 \uc7a5\ube44\ub294 \uc77c\ubc18\uc801\uc73c\ub85c \uadf8\ub7a8 \ub2e8\uc704\ub85c \ud558\uc911\uc744 \uce21\uc815\ud558\uace0, \uc774\ub97c \ucea1\uc290\uc758 \ubcc0\ud615\uacfc \uc5f0\uad00\uc2dc\ud0b5\ub2c8\ub2e4. \uadf8 \uacb0\uacfc\ub294 \ud798 \ub300 \uc2dc\uac04 \ub610\ub294 \ud798 \ub300 \uac70\ub9ac \uadf8\ub798\ud504 \ud615\ud0dc\ub85c \ud45c\uc2dc\ub429\ub2c8\ub2e4. \ubcc0\ud615 \uacfc\uc815\uc5d0\uc11c\ub294 \ub2e4\uc591\ud55c \uc870\uc9c1\ud559\uc801 \ub9e4\uac1c\ubcc0\uc218\uac00 \uc791\uc6a9\ud560 \uc218 \uc788\uc73c\uba70, \uc2dc\ud5d8\uc744 \ud1b5\ud574 \uc0dd\uc131\ub41c \ud798-\ubcc0\ud615 \uace1\uc120\uc5d0\uc11c \uc774\ub97c \uad00\ucc30\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uc9c0\ub09c 40\ub144 \ub3d9\uc548 \uc870\uc9c1 \ubd84\uc11d\uc744 \ud65c\uc6a9\ud55c \uc218\ub9ce\uc740 \ud559\uc220 \uc5f0\uad6c\uc5d0\uc11c \uc774\ub7ec\ud55c \uac70\ub3d9\uacfc \uac10\uac01\uc801 \ud2b9\uc131\uc744 \uc5f0\uad00 \uc9c0\uc5b4 \ubd84\uc11d\ud574 \uc654\uc2b5\ub2c8\ub2e4.&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\ucea1\uc290 \ub8e8\ud504 \uc778\uc7a5 \uc2dc\ud5d8&nbsp;<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\uc704 \uc0ac\uc9c4\uacfc \uac19\uc774 \ud14d\uc2a4\ucc98 \ubd84\uc11d\uae30\uc5d0 \ucea1\uc290 \ub8e8\ud504 \uc778\uc7a5 \uace0\uc815 \uc7a5\uce58\ub97c \uc7a5\ucc29\ud558\uba74 \ube48 \ucea1\uc290 \uaecd\ub370\uae30\uc758 \uae30\uacc4\uc801 \uac15\ub3c4\ub97c \ube44\uad50\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uc2e4\uc81c\ub85c\ub294 \uace0\uc815 \uc7a5\uce58\uc758 \ub450 \uac1c\uc758 \uc587\uc740 \ub9c9\ub300\ub97c \ucea1\uc290 \uaecd\ub370\uae30\uc758 \ud55c\ucabd, \ubcf4\ud1b5 \ub69c\uaed1 \ubd80\ubd84\uc5d0 \uc0bd\uc785\ud569\ub2c8\ub2e4. \uadf8\ub7f0 \ub2e4\uc74c \ud558\ub2e8 \ub9c9\ub300\ub294 \uae30\uae30 \ubca0\uc774\uc2a4\uc5d0 \uace0\uc815\ud558\uace0, \uc0c1\ub2e8 \ub9c9\ub300\ub294 \ubd84\uc11d\uae30\uc758 \uad6c\ub3d9 \uc7a5\uce58\uc5d0 \uc5f0\uacb0\ud569\ub2c8\ub2e4. \uad6c\ub3d9 \uc7a5\uce58\ub294 \uc0c1\ub2e8 \ub9c9\ub300\ub97c \ucd08\ub2f9 0.1~1.0mm\uc758 \uc77c\uc815\ud55c \uc18d\ub3c4\ub85c \ub4e4\uc5b4 \uc62c\ub824 \ucea1\uc290 \uc258\uc744 \uc815\ud574\uc9c4 \uac70\ub9ac\ub9cc\ud07c \ub298\ub9bd\ub2c8\ub2e4. \uacbd\uc6b0\uc5d0 \ub530\ub77c \uc774 \uc2dc\ud5d8\uc73c\ub85c \uc778\ud574 \uc258\uc774 \ud30c\uc5f4\ub418\uae30\ub3c4 \ud569\ub2c8\ub2e4.&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\uc555\ucd95 \ud14c\uc2a4\ud2b8&nbsp;<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\uc9c8\uac10 \ubd84\uc11d\uae30\ub294 \ub450 \uac00\uc9c0 \uc2dc\ud5d8 \ubc29\ubc95\uc744 \ud1b5\ud574 \uc5f0\uc9c8 \uc824\ub77c\ud2f4 \ucea1\uc290(\uc18c\ud504\ud2b8\uc824)\uc758 \uc555\ucd95 \uac15\ub3c4\ub97c \uce21\uc815\ud560 \uc218\ub3c4 \uc788\uc2b5\ub2c8\ub2e4. \uccab \ubc88\uc9f8 \ubc29\ubc95\uc5d0\uc11c\ub294 \uc9c1\uacbd 36mm\uc758 \ud504\ub85c\ube0c\ub97c \uc0ac\uc6a9\ud558\uc5ec \ubc00\ubd09 \uac15\ub3c4\ub97c \uc815\ub7c9\ud654\ud558\uba70(\uadf8\ub9bc 2), \ub450 \ubc88\uc9f8 \ubc29\ubc95\uc778 \uad00\ud1b5 \uc2dc\ud5d8\uc5d0\uc11c\ub294 \uc9c1\uacbd 2mm\uc758 \uc6d0\ud1b5\ud615 \ud504\ub85c\ube0c\ub97c \uc0ac\uc6a9\ud558\uc5ec \uc18c\ud504\ud2b8\uc824\uc758 \ud30c\uc5f4 \uc9c0\uc810\uc744 \ud655\uc778\ud569\ub2c8\ub2e4. \uc774 \ub450 \uac00\uc9c0 \uc2dc\ud5d8\uc740 \uc18c\ud504\ud2b8\uc824\uc758 \uac15\ub3c4\uc0c1 \ucde8\uc57d\uc810\uc744 \ud30c\uc545\ud560 \ubfd0\ub9cc \uc544\ub2c8\ub77c, \ud3ec\uc7a5 \ub610\ub294 \uc6b4\uc1a1 \uc911\uc5d0 \uc18c\ud504\ud2b8\uc824\uc774 \ud30c\uc5f4\ub420 \uc218 \uc788\ub294 \uc0c1\ud669\uc744 \uc2dc\ubbac\ub808\uc774\uc158\ud569\ub2c8\ub2e4. \uacbd\uc9c8 \ub610\ub294 \uc5f0\uc9c8 \ucea1\uc290\uc758 \ubc00\ubd09 \uac15\ub3c4\ub97c \uce21\uc815\ud560 \ub54c\ub294 \ucea1\uc290\ubcf4\ub2e4 \uc9c1\uacbd\uc774 \ud070 \uc555\ucd95 \ud504\ub85c\ube0c\ub97c \uc0ac\uc6a9\ud558\uace0, \ubc00\ubd09\ubd80\uac00 \ud504\ub85c\ube0c\uc640 \uac00\ud574\uc9c0\ub294 \ud798 \ubaa8\ub450\uc5d0 \ub300\ud574 \uc218\uc9c1\uc774 \ub418\ub3c4\ub85d \ubc30\uce58\ud558\uc2ed\uc2dc\uc624. \uc544\ub798 \uc0ac\uc9c4\uc744 \ucc38\uc870\ud558\uc2ed\uc2dc\uc624. \ud45c 2\uc5d0\ub294 \uc18c\ud504\ud2b8\uc824 \uacbd\ub3c4 \uc2dc\ud5d8 \uacb0\uacfc\uac00 \uc815\ub9ac\ub418\uc5b4 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\uc824 \uac15\ub3c4 \uc2dc\ud5d8&nbsp;<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\uc824\ub77c\ud2f4\uc740 \ub2e4\uc591\ud55c \uc0b0\uc5c5 \ubd84\uc57c\uc640 \uc6a9\ub3c4\ub85c \ub110\ub9ac \uc0ac\uc6a9\ub418\uba70, \uac70\uc758 \ubaa8\ub4e0 \uacbd\uc6b0\uc5d0\uc11c \uc824\ub77c\ud2f4 \uc81c\uc870\uc0ac\uc640 \ucd5c\uc885 \uc0ac\uc6a9\uc790 \ubaa8\ub450 \uc824\ub77c\ud2f4\uc758 \ud6a8\ub2a5\uc744 \ub098\ud0c0\ub0b4\ub294 \uc824 \uac15\ub3c4\ub97c \uce21\uc815\ud569\ub2c8\ub2e4. \uc824 \uac15\ub3c4\ub294 \uc8fc\ub85c \ube14\ub8f8 \uac15\ub3c4\uc5d0 \ub530\ub77c \uacb0\uc815\ub429\ub2c8\ub2e4. \ub2e4\uc74c \ud398\uc774\uc9c0\uc758 \uc0ac\uc9c4\uc740 \uc2dc\ud5d8\uc744 \uae30\ub2e4\ub9ac\uace0 \uc788\ub294 \uc824\ub77c\ud2f4 \uc2dc\ub8cc\uac00 \ub2f4\uae34 \ube14\ub8f8 \uc6a9\uae30\ub97c \ubcf4\uc5ec\uc90d\ub2c8\ub2e4.&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\ud45c\uc900 \ube14\ub8f8 \ud504\ub85c\ube0c, \ube14\ub8f8 \ubcd1 \ubc0f \uc824\ub77c\ud2f4 \uc695\uc870\uac00 \uc7a5\ucc29\ub41c \ud14d\uc2a4\ucc98 \ubd84\uc11d\uae30\ub97c \uc0ac\uc6a9\ud558\uba74 \uac04\ub2e8\ud55c \ud14c\uc2a4\ud2b8\ub97c \uc218\ud589\ud558\uc5ec \uc824\uc758 \uac15\ub3c4\ub97c \ube60\ub974\uace0 \uc815\ud655\ud558\uac8c \uce21\uc815\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uc824\uc758 \uac15\ub3c4\ub294 \uc824\uc744 \ud2b9\uc815 \uac70\ub9ac\ub9cc\ud07c \ubcc0\ud615\uc2dc\ud0a4\ub294 \ub370 \ud544\uc694\ud55c \ud798\uc73c\ub85c \uce21\uc815\ub429\ub2c8\ub2e4.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\uc9c8\uac10 \ubd84\uc11d\uae30\ub97c \uc0ac\uc6a9\ud558\uba74 \uc601\uad6d \ud45c\uc900 \ubc29\ubc95\uc778 \u201c\uc824\ub77c\ud2f4\uc758 \uc2dc\ub8cc \ucc44\ucde8 \ubc0f \uc2dc\ud5d8\u201d(BS757: 1975)\uc5d0 \ub530\ub77c \uc824\ub77c\ud2f4\uc758 \uac94 \uac15\ub3c4\ub97c \uc815\ub7c9\ud654\ud558\uac70\ub098, \ubbf8\uad6d \uc824\ub77c\ud2f4 \uc81c\uc870\uc5c5\uccb4 \ud611\ud68c(GMIA) \ub610\ub294 1998\ub144\uc5d0 GMIA \ud45c\uc900\uc744 \ucc44\ud0dd\ud55c \uc720\ub7fd \uc824\ub77c\ud2f4 \uc81c\uc870\uc5c5\uccb4 \ud611\ud68c\uc758 \ud45c\uc900\uc744 \uc0ac\uc6a9\ud558\uc5ec \uce21\uc815\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uadf8 \uacb0\uacfc, \ud604\uc7ac\uc758 \ubaa8\ub4e0 \ubc29\ubc95\uc5d0\uc11c\ub294 \ub0a0\uce74\ub85c\uc6b4 \ubaa8\uc11c\ub9ac\uac00 \uc788\ub294 \uc9c1\uacbd 12.7mm\uc758 \ud3c9\ud3c9\ud55c \uc6d0\ud1b5\ud615 \ud504\ub85c\ube0c \uc0ac\uc6a9\uc744 \uaddc\uc815\ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4. (\uc720\ub7fd \ubc29\uc2dd\uc740 \ub0a0\uce74\ub85c\uc6b4 \ubaa8\uc11c\ub9ac \ub300\uc2e0 \ubc18\uacbd\uc774 \uc791\uc740 \ud504\ub85c\ube0c\ub97c \uaddc\uc815\ud588\uc2b5\ub2c8\ub2e4.)&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\uc774 \ubc29\ubc95\uc740 HPMC\uc640 \uac19\uc740 \ub2e4\ub978 \ucea1\uc290 \uaecd\uc9c8 \uc7ac\ub8cc\uc5d0\ub3c4 \uc801\uc6a9\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uae30\uacc4\uc801 \uac15\ub3c4\uac00 \ub192\uc740 \uc2dc\ub8cc\ub97c \uc2dc\ud5d8\ud560 \ub54c\ub294 \uc6a9\ub7c9\uc774 \ub354 \ud070 \ud558\uc911 \uc140\uc744 \uc0ac\uc6a9\ud558\ub294 \uac83\uc744 \uace0\ub824\ud558\uc2ed\uc2dc\uc624. \ub9c8\ucc2c\uac00\uc9c0\ub85c, \ud0c4\uc131 \uc131\ubd84\uc774 \ub192\uc740 \uc2dc\ub8cc\uc758 \uacbd\uc6b0 \uc2dc\ud5d8 \uac70\ub9ac\ub97c \ub298\ub824\uc57c \ud560 \uc218\ub3c4 \uc788\uc2b5\ub2c8\ub2e4.&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\uacb0\ub860&nbsp;<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\ud14d\uc2a4\ucc98 \ubd84\uc11d\uc740 \uc644\uc81c\ud488\uc5d0 \uc601\ud5a5\uc744 \ubbf8\uce58\ub294 \uc8fc\uc694 \ud2b9\uc131\uc744 \ud30c\uc545\ud568\uc73c\ub85c\uc368 \uc5f0\uad6c\uac1c\ubc1c(R&amp;D), \uacf5\uc815 \ucd5c\uc801\ud654 \ubc0f \uc0dd\uc0b0 \uacfc\uc815\uc5d0\uc11c \ud544\uc218\uc801\uc778 \uc5ed\ud560\uc744 \ud569\ub2c8\ub2e4. \uc774\ub294 \uac1c\ubc1c \ucd08\uae30 \ub2e8\uacc4\uc5d0\uc11c \uc758\uc0ac\uacb0\uc815\uc744 \uc548\ub0b4\ud558\uace0, \uc0dd\uc0b0 \ub77c\uc778\uc5d0\uc11c\uc758 \uacf5\uc815 \uc81c\uc5b4\ub97c \uac00\ub2a5\ud558\uac8c \ud569\ub2c8\ub2e4. \ub610\ud55c \ud5c8\uc6a9 \uc0c1\ud55c \ubc0f \ud558\ud55c\uc744 \uc124\uc815\ud568\uc73c\ub85c\uc368 \uc81c\uc870 \uacf5\uc815\uc744 \ucd5c\uc801\ud654\ud558\uace0 \ud3d0\uae30\ubb3c\uc744 \uc904\uc77c \uc218 \uc788\ub3c4\ub85d \uc9c0\uc6d0\ud569\ub2c8\ub2e4.&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\uc5f0\uc9c8 \uc824\ub77c\ud2f4 \ucea1\uc290\uc758 \uc6a9\ucd9c\ubc95 \uac1c\ubc1c\uc5d0 \ub530\ub978 \uacfc\uc81c<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Noyes\uc640 Whitney\ub294 1897\ub144 \uc6a9\ucd9c \uacfc\uc815\uc744 \ubb3c\ub9ac\ud654\ud559\uc758 \ud55c \ubd84\uc57c\ub85c \ucd5c\ucd08\ub85c \uccb4\uacc4\ud654\ud588\uc73c\uba70, \uc774\ub294 \uc57d\ubb3c \ud22c\uc5ec\uc5d0 \uc788\uc5b4 \uadf8 \uc911\uc694\uc131\uc774 \ubd80\uac01\ub428\uc5d0 \ub530\ub77c \uc774\ud6c4 \uc57d\ud559 \ubd84\uc57c\uc5d0\uc11c\ub3c4 \uc720\uc0ac\ud55c \uc5f0\uad6c\uac00 \uc774\ub8e8\uc5b4\uc9c0\uac8c \ub418\uc5c8\ub2e4 [74]. 1950\ub144\ub300\uc5d0 \uc6a9\ud574\ub41c \uc57d\ubb3c\ub9cc\uc774 \uc778\uccb4 \ub0b4\ub85c \ud655\uc0b0\ub420 \uc218 \uc788\ub2e4\ub294 \uc0ac\uc2e4\uc774 \ubc1d\ud600\uc9c0\uba74\uc11c \uc0dd\uccb4 \uc774\uc6a9\ub960\uacfc \uad00\ub828\ud558\uc5ec \uc57d\ubb3c \uc6a9\ud574\uc758 \uc911\uc694\uc131\uc774 \uc778\uc2dd\ub428\uc5d0 \ub530\ub77c \uace0\ud615 \uc81c\ud615\uc758 \uc6a9\ud574\uc5d0 \ub300\ud55c \uad00\uc2ec\uc774 \ub192\uc544\uc84c\uc2b5\ub2c8\ub2e4 [74,75,76,77,78]. \uc57d\ubb3c\uc758 \ub0ae\uc740 \uc6a9\ud574\ub3c4\uc640 \ub0ae\uc740 \uc6a9\ucd9c \uc18d\ub3c4\ub294 \uc791\uc6a9 \ubd80\uc704\uc5d0\uc11c \uc57d\ubb3c\uc758 \uc774\uc6a9\ub960\uc744 \uc800\ud558\uc2dc\ud0a4\uace0, \uacb0\uacfc\uc801\uc73c\ub85c \uc0dd\uccb4 \ub0b4 \uce58\ub8cc \ud6a8\uacfc\uc758 \uc2e4\ud328\ub85c \uc774\uc5b4\uc9c8 \uac00\ub2a5\uc131\uc774 \uc788\uc2b5\ub2c8\ub2e4. \uc774\ub294 \uc57d\ubb3c\uc774 \ud45c\uc801 \ubd80\uc704\uc5d0 \ub300\ud574 \uc774\uc0c1\uc801\uc778 \uad6c\uc870\ub97c \uac00\uc9c0\uace0 \uc788\ub2e4\ub294 \uc0ac\uc2e4\uacfc\ub294 \ubcc4\uac1c\uc758 \ubb38\uc81c\uc785\ub2c8\ub2e4. \ubcf8\uc9c8\uc801\uc73c\ub85c, \uc57d\ubb3c\uc758 \uc6a9\ud574\ub3c4\uac00 \ub108\ubb34 \ub0ae\uc73c\uba74 \ud45c\uc801 \ubd80\uc704\uc5d0 \ub3c4\ub2ec\ud560 \uc218 \uc5c6\uac8c \ub418\uc5b4 \uce58\ub8cc\uc801 \uad00\ub828\uc131\uc774 \uc5c6\uc5b4\uc9d1\ub2c8\ub2e4. \uc8fc\uc5b4\uc9c4 \uc81c\ud615\uc5d0\uc11c \uc57d\ubb3c\uc758 \uc6a9\ucd9c \ud2b9\uc131\uc744 \ud30c\uc545\ud558\ub294 \uac83\uc740 \uc758\uc57d\ud488 \uac1c\ubc1c\uc758 \uc131\uacf5\uc5d0 \ub9e4\uc6b0 \uc911\uc694\ud569\ub2c8\ub2e4. \uc774 \uc139\uc158\uc5d0\uc11c\ub294 SGC \uc6a9\ucd9c\uc5d0 \ub300\ud55c \ucd5c\uc2e0 \uae30\uc220\uacfc SGC \uc6a9\ucd9c\ubc95 \uac1c\ubc1c\uc5d0 \uad00\ud55c \ub2e4\uc591\ud55c \uc2e4\uc6a9\uc801\uc778 \uac1c\ub150\uc744 \ub2e4\ub8f9\ub2c8\ub2e4.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\uc6a9\ucd9c \uc2dc\ud5d8\uc740 \uc561\uccb4\/\uace0\uccb4 \uacc4\uba74, \uc628\ub3c4, \uad50\ubc18 \uc18d\ub3c4 \ub610\ub294 \uc6a9\ub9e4 \uc870\uc131\uc5d0 \ub300\ud55c \ud45c\uc900\ud654\ub41c \uc870\uac74 \ud558\uc5d0\uc11c \uc81c\ud615\uc73c\ub85c\ubd80\ud130 \uc6a9\ucd9c \ub9e4\uccb4 \ub610\ub294 \uc6a9\ub9e4\ub85c \uc57d\ubb3c\uc774 \ubc29\ucd9c\ub418\ub294 \uc18d\ub3c4\ub97c \ud3c9\uac00\ud558\uae30 \uc704\ud574 \uc0ac\uc6a9\ub418\ub294 \uacf5\uc2dd \uc2dc\ud5d8\ubc95\uc785\ub2c8\ub2e4. \uc6a9\ucd9c \uc2dc\ud5d8\uc740 SGC\ub97c \ud3ec\ud568\ud55c \ub2e4\uc591\ud55c \uc81c\ud615\uc5d0\uc11c \uc6d0\ub8cc\uc758\uc57d\ud488(API)\uc758 \uccb4\uc678 \ubc29\ucd9c \uc18d\ub3c4\uc640 \uc815\ub3c4\ub97c \uce21\uc815\ud558\ub294 \ub370 \uc788\uc5b4 \uc911\uc694\ud574\uc84c\uc2b5\ub2c8\ub2e4. \uc6a9\ucd9c\uc740 \uc6a9\uc9c8(\uc608: API) \ubd84\uc790\uac00 \uc6a9\ub9e4\uc5d0 \uc6a9\ud574\ub418\uc5b4 \uc6a9\uc561\uc744 \ud615\uc131\ud558\ub294 \uacfc\uc815\uc73c\ub85c \uc124\uba85\ub420 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uc81c\ud615\uc758 \uc0dd\uccb4 \ub0b4 \uc720\ud6a8\uc131\uc740 \uc804\uc2e0 \ud761\uc218\ub97c \uc704\ud574 \uc57d\ubb3c\uc744 \ubc29\ucd9c\ud558\ub294 \ub2a5\ub825\uc5d0 \ub2ec\ub824 \uc788\uc2b5\ub2c8\ub2e4. SGC\uc758 \uc6a9\ucd9c\uc740 \uc138 \uac00\uc9c0 \uc8fc\uc694 \ub2e8\uacc4\ub97c \uac70\uce58\ub294\ub370, \uccab \ubc88\uc9f8\ub294 \uc824\ub77c\ud2f4 \uaecd\uc9c8\uc758 \ud33d\uc724 \ubc0f \ud30c\uc5f4\uc774\uba70, \uadf8 \ub2e4\uc74c\uc740 \ucda9\uc804\uc7ac\uc758 \ubc29\ucd9c \ubc0f \ubd84\uc0b0, \ub9c8\uc9c0\ub9c9\uc73c\ub85c \uc6a9\ucd9c \ub9e4\uccb4 \ub0b4\uc5d0\uc11c\uc758 \ud65c\uc131 \uc131\ubd84\uc758 \uc6a9\ucd9c\uc785\ub2c8\ub2e4( ). \uc774\ub7ec\ud55c \uacfc\uc815\ub4e4\uc740 \uc5f0\uc18d\uc801\uc73c\ub85c \ubc1c\uc0dd\ud558\ubbc0\ub85c, \uac00\uc7a5 \ub290\ub9b0 \ub2e8\uacc4\uac00 SGC\uc758 \uc6a9\ucd9c \uc18d\ub3c4\ub97c \uacb0\uc815\ud55c\ub2e4. \uc774 \uacbd\uc6b0 \uac00\uc7a5 \ub290\ub9b0 \ub2e8\uacc4\uac00 \uc57d\ubb3c \ud761\uc218\uc758 \uc804\ubc18\uc801\uc778 \uc18d\ub3c4\uc640 \uc815\ub3c4\ub97c \uc88c\uc6b0\ud55c\ub2e4. \uadf8\ub7ec\ub098 \uc774\ub294 \uc57d\uc81c\ub9c8\ub2e4 \ub2e4\ub974\ub2e4. \ub09c\uc6a9\uc131 \uc57d\ubb3c, \ud2b9\ud788 BCS II \ubc0f IV\uc5d0 \uc18d\ud558\ub294 \uc57d\ubb3c\uc758 \uacbd\uc6b0, \uc6a9\ucd9c\uc774 \ud761\uc218 \uacfc\uc815\uc758 \uc18d\ub3c4 \uc81c\ud55c \ub2e8\uacc4\uac00 \ub41c\ub2e4. \ubc18\uba74, \uc6a9\ud574\ub3c4\uac00 \ub192\uc740 \uc57d\ubb3c\uc758 \uacbd\uc6b0 \uc6a9\ud574\uac00 \ube60\ub974\uac8c \uc9c4\ud589\ub418\uba70, \ud761\uc218 \uc18d\ub3c4\uc640 \uc815\ub3c4\ub294 \uc138\ud3ec\ub9c9 \ud22c\uacfc\uc131, \uc704\uc7a5\uad00 \ub0b4 \ud6a8\uc18c \ubd84\ud574, \ub610\ub294 \uccab \ubc88\uc9f8 \ud1b5\uacfc \ub300\uc0ac(first-pass metabolism)\uc640 \uac19\uc740 \ub2e4\ub978 \uc694\uc778\uc758 \uc601\ud5a5\uc744 \ubc1b\uc744 \uc218 \uc788\ub2e4.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\uc758\uc57d\ud488\uc5d0 \uc788\uc5b4 \uac00\uc7a5 \uc911\uc694\ud55c \uc694\uac74 \uc911 \ud558\ub098\ub294 \uc0dd\uccb4 \ub0b4\uc5d0\uc11c \uc720\ud6a8\uc131\ubd84\uc744 \uc608\uce21 \uac00\ub2a5\ud55c \uc18d\ub3c4\ub85c \ubc29\ucd9c\ud574\uc57c \ud55c\ub2e4\ub294 \uc810\uc774\ub2e4 [9, 82, 83]. \uc57d\ubb3c \ubc29\ucd9c \ub3d9\uc5ed\ud559\uc740 \ubd88\ud65c\uc131 \ub9e4\ud2b8\ub9ad\uc2a4\ub97c \ud1b5\ud55c \ud655\uc0b0, \uac94\uc744 \ud1b5\ud55c \ud655\uc0b0, \uc0bc\ud22c \ubc29\ucd9c, \uc774\uc628 \uad50\ud658 \ub610\ub294 pH \uac10\uc751\ud615 \uc804\ub2ec \uc2dc\uc2a4\ud15c\uacfc \uac19\uc740 \ud574\ub2f9 \uc2dc\uc2a4\ud15c\uc758 \ubc29\ucd9c \uae30\uc804\uc5d0 \ub530\ub77c \ub2ec\ub77c\uc9c4\ub2e4. \uc6d0\ub8cc\uc57d\ubb3c \ubc29\ucd9c\uc5d0 \uad00\uc5ec\ud558\ub294 \ub2e4\uc591\ud55c \uba54\ucee4\ub2c8\uc998 \uc911 \ud655\uc0b0\uc774 \uc8fc\ub41c \ubc29\ucd9c \uba54\ucee4\ub2c8\uc998\uc774\uba70, \uc774\ub294 \ubaa8\ub4e0 \uc2dc\uc2a4\ud15c\uc5d0\uc11c \ub2e4\uc591\ud55c \uc815\ub3c4\ub85c \ubc1c\uc0dd\ud55c\ub2e4. \ubb3c\ub9ac\ud654\ud559 \ubd84\uc57c\uc758 \uc6a9\uc9c8 \ubc29\ucd9c \ubaa8\ub378\uc740 \uc57d\ubb3c \uc804\ub2ec \uc2dc\uc2a4\ud15c\uc758 \uac1c\ubc1c\ubcf4\ub2e4 \uc218\ub144 \uc55e\uc11c \ub4f1\uc7a5\ud588\ub2e4 [ 77 , 78 ]. 1961\ub144, \ud788\uad6c\uce58(Higuchi)\ub294 \ud655\uc0b0 \uc81c\uc5b4 \uc2dc\uc2a4\ud15c\uc5d0 \ub300\ud55c \uc57d\ubb3c \ubc29\ucd9c \uc218\ud559\uc801 \ubaa8\ub378\uc744 \uc81c\uc2dc\ud588\ub2e4 [ 84 ]. \uc800\uc790\ub294 \uc5f0\uace0\uac00 \uade0\uc77c\ud558\uac8c \ubd84\uc0b0\ub418\uc5b4 \ud3c9\uba74 \ub9e4\ud2b8\ub9ad\uc2a4\uc640 \ub9e4\uc9c8 \ub0b4\uc5d0\uc11c \ubc29\ucd9c\ub41c\ub2e4\uace0 \uac00\uc815\ud558\uace0, \uc5f0\uace0\uc758 \ubc29\ucd9c \ub3d9\uc5ed\ud559\uc744 \ubd84\uc11d\ud588\ub2e4. \uc774 \ubaa8\ub378\uc5d0 \ub530\ub974\uba74, \ubc29\ucd9c \uba54\ucee4\ub2c8\uc998\uc740 \uc2dc\uac04\uc758 \uc81c\uacf1\uadfc\uc5d0 \ube44\ub840\ud55c\ub2e4 [85]. \uc774 \ubaa8\ub378\uc740 \uadfc\uc0ac\uc801\uc778 \uc131\uaca9\uc744 \ub760\uae30 \ub54c\ubb38\uc5d0 \ubc29\ucd9c \uace1\uc120\uc758 \ucd08\uae30 60%\uc5d0 \uc801\uc6a9\ud558\ub294 \uac83\uc774 \uad8c\uc7a5\ub41c\ub2e4. 1969\ub144 \ub9d0, Wang\uc740 \ub9e4\ud2b8\ub9ad\uc2a4 \ub0b4 \ubd84\uc790 \uc774\ub3d9\uc5d0 \ub300\ud55c \ub450 \uac00\uc9c0 \ub3c5\ub9bd\uc801\uc778 \uc218\uc1a1 \uba54\ucee4\ub2c8\uc998, \uc989 Fick\uc758 \ubc95\uce59\uacfc \uace0\ubd84\uc790 \uc774\uc644\uc744 \uace0\ub824\ud55c \ub17c\ubb38\uc744 \ubc1c\ud45c\ud588\ub2e4 [ 86 ]. \uadf8 \ud6c4, 1985\ub144\uc5d0 Peppas\ub294 \uace0\ubd84\uc790 \uc7a5\uce58\uc5d0\uc11c\uc758 \uc57d\ubb3c \ubc29\ucd9c\uc744 \uc77c\ubc18\ud654\ub41c \ubc29\uc2dd\uc73c\ub85c \uc124\uba85\ud558\uae30 \uc704\ud574 \ubc18\uacbd\ud5d8\uc801 \ubc29\uc815\uc2dd\uc778 \uc9c0\uc218 \ubc95\uce59\uc744 \ub3c4\uc785\ud588\uc2b5\ub2c8\ub2e4 [ 87 , 88 ].<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\uc5ec\uae30\uc11c \uc18c\uac1c\ud574\uc57c \ud560 \ub610 \ub2e4\ub978 \uac1c\ub150\uc740 \uc57d\ubb3c \ubc29\ucd9c \ud604\uc0c1\uc785\ub2c8\ub2e4. \uc57d\ubb3c\uc758 \uc6a9\ucd9c \uc18d\ub3c4\uc640 \ubc29\ucd9c \uc18d\ub3c4\ub294 \uc0c1\ub2f9\ud788 \ub2e4\ub985\ub2c8\ub2e4. \uc57d\ubb3c \ubc29\ucd9c\uc774\ub780 \uc81c\uc81c \ub0b4\uc758 \uc57d\ubb3c\uc774 \uc81c\uc81c\uc758 \ud655\uc0b0 \ub610\ub294 \uc6a9\ucd9c\uc744 \ud1b5\ud574 \uc6a9\ucd9c \ub9e4\uccb4\ub098 \ud761\uc218 \ubd80\uc704\ub85c \ubc29\ucd9c\ub418\ub294 \uacfc\uc815\uc744 \ub9d0\ud569\ub2c8\ub2e4. \uc758\uc57d\ud488 \ub0b4 \uc6d0\ub8cc\uc758\uc57d\ud488(API)\uc758 \ubb3c\ub9ac\uc801 \ud615\ud0dc\uc5d0 \ub530\ub77c API\uc758 \ubc29\ucd9c\uc740 \ub290\ub9b4 \uc218\ub3c4 \uc788\uace0 \uc989\uac01\uc801\uc77c \uc218\ub3c4 \uc788\ub2e4. \uc55e \uc139\uc158\uc5d0\uc11c \uc124\uba85\ud55c \ubc14\uc640 \uac19\uc774, \uc6a9\ud574\ub294 \uc6a9\uc9c8\uc758 \ubd84\uc790\uac00 \uc2dc\uac04\uc758 \ud568\uc218\ub85c\uc11c \uc6a9\ub9e4 \ub9e4\uc9c8\uc5d0 \uc6a9\ud574\ub418\ub294 \uacfc\uc815\uc774\ub2e4. \ubc18\uba74, \u201c\ubc29\ucd9c\u201d\uc774\ub77c\ub294 \uc6a9\uc5b4\ub294 \ub300\uac1c \ud6e8\uc52c \ub354 \ubcf5\uc7a1\ud55c \ud604\uc0c1\uc744 \uac00\ub9ac\ud0a8\ub2e4. \ubc29\ucd9c\uc740 \uc5ec\ub7ec \ub2e8\uacc4 \uc911 \ud558\ub098\ub85c \ucea1\uc290 \uc6a9\ud574\ub97c \ud3ec\ud568\ud55c\ub2e4. \uc218\uc131 \ub9e4\uc9c8\uacfc \uc811\ucd09\ud558\uba74 \ubb3c\uc774 \uc5f0\uc9c8 \uc824\ub77c\ud2f4 \uaecd\uc9c8\uc744 \ud22c\uacfc\ud558\uc5ec API\ub97c \uc801\uc5b4\ub3c4 \ubd80\ubd84\uc801\uc73c\ub85c \uc6a9\ud574\uc2dc\ud0a8\ub2e4 [ 81 ]. \uadf8 \ud6c4, \uc6a9\ud574\ub41c API\ub294 \ub18d\ub3c4 \uad6c\ubc30\uc5d0 \uc758\ud574 \ucea1\uc290 \uaecd\uc9c8\uc744 \ud1b5\ud574 \ud655\uc0b0\ub41c\ub2e4. \ub610\ud55c, \uc824\ub77c\ud2f4 \uaecd\uc9c8\uc740 \uc784\uacc4 \uc218\ubd84 \ud568\ub7c9\uc5d0 \ub3c4\ub2ec\ud558\ub294 \uc989\uc2dc \uc0c1\ub2f9\ud55c \ud33d\ucc3d\uc744 \uc77c\uc73c\ud0ac \uc218 \uc788\uc73c\uba70, \uc774\ub85c \uc778\ud574 \uaecd\uc9c8\uc774 \ud30c\uc5f4\ub418\uace0, \uc774\uc5b4\uc11c \ubc29\ucd9c \ub9e4\uc9c8 \ub0b4\uc5d0\uc11c \ubd84\uc0b0 \ubc0f \ucd5c\uc885\uc801\uc778 \uc6a9\ud574\uac00 \ubc1c\uc0dd\ud558\uac8c \ub41c\ub2e4. \ub530\ub77c\uc11c SGC \uc81c\ud615\uc5d0\uc11c API\ub97c \ubc29\ucd9c\ud558\ub294 \uacfc\uc815\uc5d0\ub294 \uc5ec\ub7ec \ub2e8\uacc4\uac00 \ud3ec\ud568\ub418\uba70, \uadf8\uc911 \uc57d\ubb3c \uc6a9\ud574\ub294 \ub2e8 \ud558\ub098\uc758 \ub2e8\uacc4\uc5d0 \ubd88\uacfc\ud558\ub2e4.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\uac01 \uc6a9\ub9e4\uc5d0\uc11c \uc758\uc57d\ud488\uc758 \uc6a9\ucd9c \uc18d\ub3c4\ub294 \uace0\uccb4 \uc785\uc790\uc5d0\uc11c \uac1c\ubcc4 \uc57d\ubb3c \ubd84\uc790\uac00 \uc6a9\uc561\uc73c\ub85c \uc774\ub3d9\ud558\ub294 \uc18d\ub3c4\ub85c \uc815\uc758\ub418\uba70, \uc8fc\uc5b4\uc9c4 \uc2dc\uac04 \uac04\uaca9\uc5d0 \ub300\ud55c \uc6a9\ucd9c\ub41c \uc6d0\ub8cc\uc758\uc57d\ud488(API)\uc758 \ub18d\ub3c4\ub85c \ud45c\ud604\ub420 \uc218 \uc788\ub2e4. \uc6a9\ud574 \uc18d\ub3c4\ub294 API\uc758 \ud615\ud0dc\uc5d0 \ub530\ub77c \ub2ec\ub77c\uc9c8 \uc218 \uc788\ub294\ub370, \uc608\ub97c \ub4e4\uc5b4 \ube44\uacb0\uc815\uc9c8 \ud615\ud0dc\ub294 \uc77c\ubc18\uc801\uc73c\ub85c \uacb0\uc815\uc9c8 \ud615\ud0dc\uc758 API\uc5d0 \ube44\ud574 \uc6a9\ud574 \uc18d\ub3c4\uac00 \ube60\ub985\ub2c8\ub2e4 [ 79 , 80 ].<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\uc6a9\ud574 \uacfc\uc815\uc744 \ub17c\uc758\ud560 \ub54c \ub610 \ub2e4\ub978 \uc911\uc694\ud55c \uc5f4\uc5ed\ud559\uc801 \uc131\uc9c8\uc740 \uc6a9\ud574\ub3c4\uc774\uba70, \uc774\ub294 \ubab0\ub18d\ub3c4, \ubab0\uc54c\ub9ac, \ubab0\ubd84\uc728, \ubab0\ube44, \ubc31\ub9cc\ubd84\uc728(ppm) \ub4f1 \uc5ec\ub7ec \uac00\uc9c0 \ubc29\uc2dd\uc73c\ub85c \ud45c\ud604\ub420 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uc608\ub97c \ub4e4\uc5b4, \uc57d\ubb3c \ubd84\uc790\uc758 \uacbd\uc6b0, \uc815\uc758\ub41c \uc628\ub3c4\uc640 \uc555\ub825\uc5d0\uc11c \uc6a9\ub9e4 \uc0c1\uc5d0 \ub178\ucd9c\ub41c \uacfc\uc789\uc758 \uace0\uccb4\ub97c \uc0dd\uac01\ud574\ubcf4\uc790. \ud3c9\ud615 \uc0c1\ud0dc\uc5d0\uc11c \uc6a9\uc561\uc73c\ub85c \ub4e4\uc5b4\uac00\ub294 \uc57d\ubb3c \ubd84\uc790\uc758 \uc218\ub294 \uc7ac\uce68\uc804\ub418\ub294 \uc57d\ubb3c \ubd84\uc790\uc758 \uc218\uc640 \uac19\ub2e4. \uc774\ub7ec\ud55c \uc870\uac74\uc5d0\uc11c \uc6a9\uc561\uc740 \uc57d\ubb3c \ubd84\uc790\ub85c \ud3ec\ud654 \uc0c1\ud0dc\uac00 \ub418\uba70, \uc774\ub7ec\ud55c \uc870\uac74 \ud558\uc5d0\uc11c \uc6a9\ud574\ub41c \uc57d\ubb3c\uc758 \ub18d\ub3c4\ub294 \u201c\ud3c9\ud615 \uc57d\ubb3c \uc6a9\ud574\ub3c4\u201d(\uc8fc\uc5b4\uc9c4 \uc628\ub3c4\uc640 \uc555\ub825\uc5d0 \ud2b9\uc815\ud55c)\ub85c \uc815\uc758\ub429\ub2c8\ub2e4 [ 89 ]. \uc6a9\ud574\ub3c4 \uc2e4\ud5d8\uc744 \uc218\ud589\ud558\ub294 \ub3d9\uc548 \uc5f4\uc5ed\ud559\uc801 \ud3c9\ud615\uc5d0 \ub3c4\ub2ec\ud55c \ud6c4\uc5d0\ub3c4 \uc2e4\ud5d8 \uc2dc\uc791 \uc2dc \uc874\uc7ac\ud558\ub358 \uace0\uccb4\uc0c1\uc774 \ubcc0\ud558\uc9c0 \uc54a\ub3c4\ub85d \ud558\ub294 \uac83\uc774 \uc911\uc694\ud558\ub2e4. \uc785\uc790 \ud06c\uae30\ub098 \ucca8\uac00\uc81c\uc758 \uc874\uc7ac, \ub610\ub294 pH\uac00 \uace0\uc720 \uc6a9\ud574\ub3c4\ub97c \ubcc0\ud654\uc2dc\ud0a4\ub294 \uacbd\uc6b0, \uc774\ub97c \ud3c9\ud615\uac12\uacfc \uad6c\ubcc4\ud558\uae30 \uc704\ud574 \uc77c\ubc18\uc801\uc73c\ub85c \u201c\uac89\ubcf4\uae30 \uc6a9\ud574\ub3c4\u201d\ub85c \ubcf4\uace0\ud55c\ub2e4\ub294 \uc810\uc740 \uc5b8\uae09\ud560 \uac00\uce58\uac00 \uc788\uc2b5\ub2c8\ub2e4. \uc6a9\ud574\ub3c4 \ub370\uc774\ud130 \ubcf4\uace0\uc758 \ubd88\uc77c\uce58\ub97c \ud53c\ud558\uae30 \uc704\ud574, \uc6a9\ud574\ub41c \uc57d\ubb3c \uc785\uc790\ub97c \ubd84\ub9ac\ud558\ub294 \ub370 \uc0ac\uc6a9\ub41c \ud544\ud130\uc758 \ud06c\uae30\ub97c \uba85\uc2dc\ud574\uc57c \ud569\ub2c8\ub2e4.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\uadf8\ub7ec\ub098 USP \uc77c\ubc18 \uc7a5(General Chapter)\uc778 \u201d\uc601\uc591 \ubcf4\ucda9\uc81c\uc758 \ubd84\ud574 \ubc0f \uc6a9\ucd9c\u2019\uc5d0\uc11c\ub294 \ucea1\uc290 \ub0b4\uc6a9\ubb3c\uc774 \ubc18\uace0\uccb4 \ub610\ub294 \uc561\uccb4\uc778 \uacbd\uc6b0 \ud30c\uc5f4 \uc2dc\ud5d8\uc744 SGC\uc758 \uc131\ub2a5 \uc2dc\ud5d8\uc73c\ub85c \uc778\uc815\ud558\uace0 \uc788\ub2e4 [92]. \ud30c\uc5f4 \uc2dc\ud5d8\uc740 '\uc6a9\ucd9c' \uc77c\ubc18 \uc7a5\uc5d0 \uc124\uba85\ub41c \ubc14\uc640 \uac19\uc774, \uc7a5\uce58 2\ub97c \uc0ac\uc6a9\ud558\uc5ec 500mL\uc758 \uce68\uc9c0 \ub9e4\uccb4\uc5d0\uc11c 50rpm\uc758 \ud68c\uc804 \uc18d\ub3c4\ub85c 15\ubd84 \ub3d9\uc548 \uc218\ud589\ub429\ub2c8\ub2e4. USP\uc5d0 \ub530\ub974\uba74, \uc2dc\ud5d8\ub41c \ubaa8\ub4e0 SGC\uac00 15\ubd84 \uc774\ub0b4\uc5d0 \ud30c\uc5f4\ub418\uba74 \uc694\uac74\uc744 \ucda9\uc871\ud55c \uac83\uc73c\ub85c \uac04\uc8fc\ub429\ub2c8\ub2e4. 15\ubd84 \uc774\uc0c1 30\ubd84 \uc774\ub0b4\uc5d0 SGC \uc911 1\uac1c \ub610\ub294 2\uac1c\uac00 \ud30c\uc5f4\ub418\ub294 \uacbd\uc6b0, 12\uac1c\uc758 SGC\ub97c \ucd94\uac00\ub85c \uc2dc\ud5d8\ud569\ub2c8\ub2e4. \ucd1d 18\uac1c\uc758 \ucea1\uc290 \uc911 15\ubd84 \uc774\uc0c1 30\ubd84 \uc774\ub0b4\uc5d0 \ud30c\uc5f4\ub418\ub294 \ucea1\uc290\uc740 2\uac1c\ub97c \ucd08\uacfc\ud560 \uc218 \uc5c6\uc2b5\ub2c8\ub2e4. \uc704\uc758 \ud30c\uc5f4 \uc2dc\ud5d8 \ud569\uaca9 \uae30\uc900\uc744 \ucda9\uc871\ud558\uc9c0 \ubabb\ud558\ub294 SGC\uc758 \uacbd\uc6b0, \ubc30\uc9c0 1L\ub2f9 550,000 \ub2e8\uc704 \uc774\ud558\uc758 \ud65c\uc131\uc744 \ub098\ud0c0\ub0b4\ub3c4\ub85d \ud30c\ud30c\uc778\uc744 \ucca8\uac00\ud558\uac70\ub098, \ubc30\uc9c0 1L\ub2f9 30 \uc824\ub77c\ud2f4 \ubd84\ud574 \ub2e8\uc704 \uc774\ud558\uc758 \ud65c\uc131\uc744 \ub098\ud0c0\ub0b4\ub3c4\ub85d \ube0c\ub85c\uba5c\ub77c\uc778\uc744 \ucca8\uac00\ud558\uc5ec \uc2dc\ud5d8\uc744 \ubc18\ubcf5\ud55c\ub2e4 [ 92 ]. Almukainzi \ub4f1[ 93 ]\uc740 \uc544\ub9cc\ud0c0\ub518, \uc778\uc0bc, \uc544\ub9c8\uc778\uc720, \uc288\ub3c4\uc5d0\ud398\ub4dc\ub9b0 \uc5fc\uc0b0\uc5fc \ubc0f \ub300\ub450\uc720\uc758 SGC\uc5d0 \ub300\ud55c \ud30c\uc5f4 \uc2dc\ud5d8\uacfc \ubd84\ud574 \uc2dc\ud5d8\uc744 \ube44\uad50\ud588\ub2e4. \uadf8\ub4e4\uc758 \ub370\uc774\ud130\uc5d0 \ub530\ub974\uba74 \ud30c\uc5f4 \uc2dc\ud5d8\uacfc \ubd84\ud574 \uc2dc\ud5d8 \uc911 \uc5b4\ub290 \ucabd\uc774 \ub354 \uc6b0\uc6d4\ud558\ub2e4\uace0 \ud560 \uc218 \uc5c6\uc5c8\ub2e4. \uadf8\ub7ec\ub098 \ud30c\uc5f4 \uc2dc\ud5d8\uc740 \ubd84\ud574 \uc2dc\ud5d8\uc5d0 \ube44\ud574 \uc885\ub9d0\uc810\uc5d0 \ub354 \ube68\ub9ac \ub3c4\ub2ec\ud588\ub2e4. \ub610 \ub2e4\ub978 \uc5f0\uad6c\uc5d0\uc11c Bachour \ub4f1[94]\uc740 \uc720\uc131 \uacbd\uad6c\uc6a9 \uc885\ud569 \ube44\ud0c0\ubbfc\uc744 \ud568\uc720\ud55c SGC\uc758 \uc548\uc815\uc131 \uc5f0\uad6c\uc5d0 \ud30c\uc5f4 \uc2dc\ud5d8\uc758 \uc801\ud569\uc131\uc744 \ud3c9\uac00\ud588\ub2e4. \uc774\ub4e4\uc758 \uc5f0\uad6c\uc5d0 \ub530\ub974\uba74 \ud30c\uc5f4 \uc2dc\ud5d8\uc740 \uc548\uc815\uc131 \uc870\uac74\uc5d0 \ubbfc\uac10\ud588\uc73c\uba70, \uc2dc\ud310 \uc758\uc57d\ud488\ub4e4\uc740 \ud30c\uc5f4 \uc2dc\ud5d8\uc744 \ud1b5\uacfc\ud588\ub2e4. \uadf8\ub7ec\ub098 \ubaa8\ub4e0 \uc7a5\uae30 \uc548\uc815\uc131 \uc2dc\ud5d8 \uc2dc\ub8cc\ub294 2\ub2e8\uacc4 \uc870\uac74\uc5d0\uc11c \ud30c\uc5f4 \uc2dc\ud5d8\uc5d0 \ubd88\ud569\uaca9\ud588\ub2e4. \uc774\ub294 \ud30c\uc5f4 \uc2dc\ud5d8\uc774 \uc77c\ubd80 \uc758\uc57d\ud488\uc758 \uc131\ub2a5 \ud3c9\uac00\uc5d0 \uc801\ud569\ud560 \uc218 \uc788\uc74c\uc744 \uc2dc\uc0ac\ud558\uc9c0\ub9cc, \uc774\ub294 \ucda9\uc804 \uc131\ubd84\uc758 \ud2b9\uc131\uc5d0 \ub530\ub77c \ub2ec\ub77c\uc9c8 \uc218 \uc788\uc74c\uc744 \uc758\ubbf8\ud55c\ub2e4.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\ubd84\ud574 \uc2dc\ud5d8\uc740 \uc989\uc2dc \ubc29\ucd9c \uc81c\ud615\uc758 \uc131\ub2a5 \uc2dc\ud5d8 \uc911 \ud558\ub098\ub85c \uac04\uc8fc\ub41c\ub2e4 [90]. USP\uc5d0 \ub530\ub974\uba74, \ubd84\ud574\ub294 \u201c\ubd88\uc6a9\uc131 \ucf54\ud305\uc774\ub098 \ucea1\uc290 \uc258\uc758 \ud30c\ud3b8\uc744 \uc81c\uc678\ud55c \uc2dc\ud5d8 \ub2e8\uc704\uc758 \uc794\uc5ec\ubb3c\uc774 \uc2dc\ud5d8 \uae30\uad6c\uc758 \uccb4\uc5d0 \ub0a8\uc544 \uc788\uac70\ub098, \ub514\uc2a4\ud06c\ub97c \uc0ac\uc6a9\ud55c \uacbd\uc6b0 \ub514\uc2a4\ud06c\uc758 \ud558\ubd80 \ud45c\uba74\uc5d0 \ubd80\ucc29\ub418\uc5b4 \uc788\ub294 \uc0c1\ud0dc\uc5d0\uc11c, \ub9cc\uc838\ubcf4\uc544 \ub2e8\ub2e8\ud55c \uc911\uc2ec\ubd80\uac00 \uc5c6\ub294 \ubd80\ub4dc\ub7ec\uc6b4 \ub369\uc5b4\ub9ac\uc778 \uc0c1\ud0dc\u201d\ub85c \uc815\uc758\ub41c\ub2e4 [91]. \ubaa8\ub4e0 \uc2dc\ud5d8 \ub2e8\uc704\uac00 \uc644\uc804\ud788 \ubd84\ud574\ub418\uc5c8\uac70\ub098, \uc2dc\ud5d8\ud55c \ucd1d 18\uac1c \ub2e8\uc704 \uc911 16\uac1c \uc774\uc0c1\uc774 \ubbf8\ub9ac \uc815\ud574\uc9c4 \uc2dc\uac04 \ub0b4\uc5d0 \ubd84\ud574\ub41c \uacbd\uc6b0, \ubd84\ud574 \uc694\uac74\uc774 \ucda9\uc871\ub41c \uac83\uc73c\ub85c \uac04\uc8fc\ud569\ub2c8\ub2e4. \uc774\ub294 API \ub610\ub294 \uc758\uc57d\ud488\uc758 \uc644\uc804\ud55c \uc6a9\ud574\ub97c \uc758\ubbf8\ud558\uc9c0\ub294 \uc54a\uc2b5\ub2c8\ub2e4.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">6.5. \uc6a9\ucd9c\ubc95 \uac1c\ubc1c\uc758 \uc2e4\ubb34\uc801 \uac1c\ub150<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\uc6a9\ucd9c \uc2dc\ud5d8\uc740 \uc758\uc57d\ud488 \uac1c\ubc1c \uc804 \uacfc\uc815\uc5d0\uc11c \uc81c\ud488\uc758 \uc131\ub2a5\uc744 \ud3c9\uac00\ud558\ub294 \uc9c0\ud45c\ub85c \ud65c\uc6a9\ub429\ub2c8\ub2e4. \uc81c\ud615 \uac1c\ubc1c \ub2e8\uacc4\uc5d0\uc11c\ub294 \uc6a9\ucd9c \uc2dc\ud5d8\uc744 \ud1b5\ud574 \ubaa8\uc758 \ud658\uacbd\uc5d0\uc11c \uc81c\ud615\uc758 \ubc29\ucd9c \ubc0f \uade0\uc77c\uc131\uc744 \uc785\uc99d\ud569\ub2c8\ub2e4. \uc81c\ud488\uc758 \uc131\ub2a5\uc774 \ud655\ub9bd\ub418\uba74, \uc774 \uc815\ubcf4\ub294 \uc548\uc815\uc131 \uc2dc\ud5d8 \uae30\uac04 \ub3d9\uc548 \uc8fc\uae30\uc801\uc73c\ub85c \ud65c\uc6a9\ub418\uc5b4 \uc81c\ud488\uc758 \ud2b9\uc131\uc774 \ubcc0\ud654\ud568\uc5d0 \ub530\ub77c \uc81c\ud488\uc774 \uc694\uad6c\ub418\ub294 \uc131\ub2a5\uc744 \uacc4\uc18d \uc720\uc9c0\ud558\ub294\uc9c0 \ub610\ub294 \uc0c1\uc2e4\ud558\ub294\uc9c0 \ud310\ub2e8\ud558\ub294 \ub370 \uc0ac\uc6a9\ub429\ub2c8\ub2e4. \uc885\uc885 \uc758\uc57d\ud488\uc758 \uc6a9\ucd9c \uc131\ub2a5\uc740 \ubb3c\ub9ac\uc801 \uac70\ub3d9\uc744 \ubcf4\uc5ec\uc8fc\uc9c0\ub9cc, \uc774\uac83\uc774 \ubc18\ub4dc\uc2dc \uc0dd\uccb4 \ub0b4(in vivo)\uc5d0\uc11c\uc758 \uc131\ub2a5\uc744 \ub098\ud0c0\ub0b4\ub294 \uac83\uc740 \uc544\ub2d9\ub2c8\ub2e4. \ub530\ub77c\uc11c \uc6a9\ucd9c \ub370\uc774\ud130\uc640 \uc57d\ub3d9\ud559 \ub370\uc774\ud130 \uac04\uc758 \uc0c1\uad00\uad00\uacc4\ub97c \ubd84\uc11d\ud568\uc73c\ub85c\uc368, \uc6a9\ucd9c \uc2dc\ud5d8\uc774 \uc57d\ubb3c\uc758 \uc131\ub2a5\uc744 \uc608\uce21\ud560 \uc218 \uc788\ub294\uc9c0\ub97c \uc785\uc99d\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uc774\ub97c \uccb4\uc678-\uc0dd\uccb4 \ub0b4 \uc0c1\uad00\uad00\uacc4(IVIVC) \ud655\ub9bd\uc774\ub77c\uace0 \ud569\ub2c8\ub2e4 [95].<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\uc774 \uc808\uc758 \ubaa9\uc801\uc740 SGC\uc6a9 \uc6a9\ucd9c \uc2dc\ud5d8\ubc95 \uac1c\ubc1c\uc5d0 \uad00\ud55c \uc2e4\ubb34\uc801 \uac1c\ub150\uc744 \uac1c\uad04\uc801\uc73c\ub85c \uc124\uba85\ud558\ub294 \ub370 \uc788\uc2b5\ub2c8\ub2e4. \uc81c\ud488\uc758 \uc6a9\ucd9c \uacfc\uc815\uc5d0\ub294 \uc5ec\ub7ec \uac00\uc9c0 \ubb3c\ub9ac\uc801 \ubcc0\ud654\uac00 \uc218\ubc18\ub41c\ub2e4\ub294 \uc810\uc744 \uc774\ud574\ud558\ub294 \uac83\uc774 \uc911\uc694\ud569\ub2c8\ub2e4. \ub2e4\ub978 \uc77c\ubc18\uc801\uc778 \uace0\ud615 \uc81c\ud615\uacfc \ub2ec\ub9ac, SGC\ub294 \uba3c\uc800 \uc824\ub77c\ud2f4\uc758 \ubb34\uacb0\uc131\uc774 \uc190\uc0c1\ub418\uace0 \uc678\ud53c\uac00 \ud30c\uc5f4\ub418\uc5b4 \ucda9\uc804\ubb3c\uc774 \ubc29\ucd9c\ub420 \uc218 \uc788\ub294 \uc9c0\uc810\uc5d0 \ub3c4\ub2ec\ud574\uc57c \ud569\ub2c8\ub2e4. \uadf8 \ud6c4, \ucda9\uc804 \uc131\ubd84\uc774 \uc6a9\ub9e4 \ub0b4\uc5d0\uc11c \ubd84\uc0b0\ub418\uc5b4 \uc720\ud6a8 \uc131\ubd84\uc774 \uc6a9\uc561\uc5d0 \uc6a9\ud574\ub418\uac70\ub098 \uc6a9\ub9e4 \uc804\uccb4\uc5d0 \uace0\ub974\uac8c \ubd84\ud3ec\ub418\uc5b4\uc57c \ud569\ub2c8\ub2e4 ( ). \ubb38\uc81c\ub294 \ucea1\uc290 \uc258\uc774 \ud658\uacbd\uc5d0 \ub9e4\uc6b0 \ubbfc\uac10\ud558\uc5ec \uacbd\ub3c4, \uac00\uad50 \uacb0\ud569 \ubc0f \uc774\uc74c\ub9e4 \ubb34\uacb0\uc131\uc5d0 \ub530\ub77c \ubcc0\ud654\ud560 \uc218 \uc788\ub2e4\ub294 \uc810\uc774\uba70, \uc774\ub7ec\ud55c \ubcc0\ud654\ub294 \uc2e4\uc81c\ub85c\ub294 \ud30c\uc5f4 \uc2dc\uac04\uc758 \ubcc0\ud654\uc784\uc5d0\ub3c4 \ubd88\uad6c\ud558\uace0 \uc6a9\ucd9c \ubcc0\ud654\ub85c \uc778\uc2dd\ub420 \uc218 \uc788\ub2e4\ub294 \uac83\uc785\ub2c8\ub2e4. \ub530\ub77c\uc11c \ucea1\uc290 \uaecd\uc9c8\uc758 \ubb34\uacb0\uc131 \ucc28\uc774\uc640 \ucda9\uc804\uc7ac\uc758 \ubcc0\ud654\ub97c \ubaa8\ub450 \uace0\ub824\ud55c \uc6a9\ucd9c \uc804\ub7b5\uc744 \uc218\ub9bd\ud558\ub294 \uac83\uc774 \ud544\uc218\uc801\uc774\ub2e4.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\uc6a9\ucd9c\ubc95 \uac1c\ubc1c\uc740 \uc544\ubb34\ub9ac \uc138\uc2ec\ud55c \uae30\uc220\uacfc \uacbd\ud5d8\uc744 \ubc14\ud0d5\uc73c\ub85c \ud558\ub354\ub77c\ub3c4 \ub9ce\uc740 \uc778\ub825\uc774 \uc18c\uc694\ub418\ub294 \uacfc\uc815\uc785\ub2c8\ub2e4. \uc77c\uc0c1\uc801\uc73c\ub85c \ud6a8\uc728\uc801\uc73c\ub85c \uc218\ud589\ud560 \uc218 \uc788\uace0 \uc548\uc815\uc801\uc73c\ub85c \ubc18\ubcf5\ud560 \uc218 \uc788\ub294 \uc808\ucc28\ub97c \uac1c\ubc1c\ud558\ub294 \ub370 \uc2dc\uac04\uc744 \ud22c\uc790\ud558\ub294 \uac83\uc774 \uc911\uc694\ud569\ub2c8\ub2e4. \uc57d\uc804\uc5d0\uc11c\ub294 pH 1.2~7.4\uc758 \ud658\uacbd\uc5d0\uc11c \uc81c\ud615\uc73c\ub85c\ubd80\ud130\uc758 \uc57d\ubb3c \ubc29\ucd9c\uc744 \ud655\uc778\ud558\uae30 \uc704\ud574 \uc6a9\ucd9c \uc2dc\ud5d8\uc744 \uc694\uad6c\ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4. \uc608\ub97c \ub4e4\uc5b4, USP [96]\ub294 \uc7a5\uc6a9 \ucf54\ud305\ub41c \uace0\ud615 \uacbd\uad6c \uc81c\ud615\uc5d0 \ub300\ud574 \uc0b0\uc131 \ud658\uacbd(\uc77c\ubc18\uc801\uc73c\ub85c 0.1 N HCl)\uc5d0\uc11c \ucf54\ud305\uc758 \ubb34\uacb0\uc131\uc744 \uc785\uc99d\ud558\uace0, \uadf8 \ud6c4 \uc911\uc131 pH \ud658\uacbd(\uac00\uae09\uc801 \uc778\uc0b0\uc5fc \uc644\ucda9\uc561)\uc5d0 \ub178\ucd9c\uc2dc\ud0a4\ub294 2\ub2e8\uacc4 \uc6a9\ucd9c\ubc95\uc744 \uc694\uad6c\ud558\uba70, \uc6a9\ucd9c\ubc95\uc758 \uccab \ubc88\uc9f8 \ub2e8\uacc4\ub294 \ucf54\ud305 \ud488\uc9c8 \ubc0f \ucf54\ud305 \uacb0\ud568 \uac00\ub2a5\uc131\uc5d0 \ub300\ud55c \uc815\ubcf4\ub97c \uc81c\uacf5\ud569\ub2c8\ub2e4. \ubbf8\uad6d \uc57d\uc804(USP)\uacfc \ubbf8\uad6d \uc2dd\ud488\uc758\uc57d\uad6d(FDA)\uc740 \uc6a9\ucd9c \uc2dc\ud5d8\ubc95\uc758 \uac1c\ubc1c \ubc0f \uac80\uc99d\uc5d0 \uad00\ud55c \uc9c0\uce68\uc744 \uc81c\uacf5\ud558\uace0 \uc788\ub2e4[96,97]. \uc774\ub7ec\ud55c \uc9c0\uce68\uc758 \ub300\ubd80\ubd84\uc740 \uc815\uc81c \ubc0f \uacbd\uc9c8 \uc824\ub77c\ud2f4 \ucea1\uc290\uacfc \uac19\uc740 \uace0\ud615 \uacbd\uad6c \uc81c\ud615\uc744 \ub300\uc0c1\uc73c\ub85c \ud558\ub098, \uc801\uc808\ud55c \ud3c9\uac00 \uc5c6\uc774\ub294 \uc774\ub7ec\ud55c \ubc29\ubc95\uc744 SGC\uc5d0 \uadf8\ub300\ub85c \uc801\uc6a9\ud560 \uc218 \uc5c6\ub2e4. \uc6a9\ucd9c\ubc95\uc758 \uc120\ud0dd\uc740 SGC\uc758 \uc81c\ud615 \ubc0f \ucda9\uc804 \ud2b9\uc131\uc5d0 \uadfc\uac70\ud574\uc57c \ud55c\ub2e4. \uadf8\ub9bc\uc740 \uc6a9\ucd9c \uc2dc\ud5d8\uc5d0 \uc0ac\uc6a9\ub418\ub294 \uc77c\ubc18\uc801\uc778 USP \uc6a9\ucd9c \uc7a5\uce58\ub97c \ubcf4\uc5ec\uc900\ub2e4.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">&nbsp;<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">SGC(\uc824\ub77c\ud2f4 \ucf54\ud305 \ucea1\uc290)\uc5d0 \ub300\ud55c \ucc28\ubcc4\ud654\ub41c \uc6a9\ucd9c \uc2dc\ud5d8\ubc95\uc744 \uac1c\ubc1c\ud558\ub824\uba74 \uc824\ub77c\ud2f4 \ubc0f \ucda9\uc804\uc7ac\uc758 \ubb3c\uc131\uacfc \uc774\uc5d0 \uc601\ud5a5\uc744 \ubbf8\uce58\ub294 \uc694\uc778\uc5d0 \ub300\ud55c \ud2b9\ubcc4\ud55c \uace0\ub824\uc640 \uc9c0\uc2dd\uc774 \ud544\uc694\ud569\ub2c8\ub2e4. \uc5ec\ub7ec \uc694\uc778\uc774 SGC\uc758 \uc6a9\ucd9c \uac70\ub3d9\uc5d0 \uc601\ud5a5\uc744 \ubbf8\uce58\uba70, \uc774\ub294 \uacb0\uacfc\uc801\uc73c\ub85c \uc6a9\ucd9c \uc2dc\ud5d8\ubc95 \uac1c\ubc1c\uc5d0 \uc601\ud5a5\uc744 \uc90d\ub2c8\ub2e4. \uc774\ub7ec\ud55c \uc694\uc778\uc5d0\ub294 \uc824\ub77c\ud2f4 \uc258\uc758 \ubb3c\ub9ac\uc801 \ud2b9\uc131, \ucda9\uc804\uc7ac\uc758 \ubb3c\ub9ac\uc801 \ubc0f \ud654\ud559\uc801 \ud2b9\uc131, \uc824\ub77c\ud2f4 \uc258\uacfc \ucda9\uc804 \uc131\ubd84 \uac04\uc758 \ud654\ud559\uc801 \uc0c1\ud638\uc791\uc6a9, \uadf8\ub9ac\uace0 \uc258\uacfc \ucda9\uc804\uc7ac \uac04\uc758 \uc218\ubd84 \uad50\ud658\uc774 \ud3ec\ud568\ub429\ub2c8\ub2e4. \ud2b9\ud788, \uc218\ubd84 \uad50\ud658\uc740 \uc824\ub77c\ud2f4 \uc258\uc758 \ucde8\uc131\uc744 \uc720\ubc1c\ud560 \uc218 \uc788\uc73c\uba70, \uc258\uacfc \ucda9\uc804\uc7ac \uac04\uc758 \ud654\ud559\uc801 \uc0c1\ud638\uc791\uc6a9\uc740 \uc824\ub77c\ud2f4\uc758 \uac00\uad50 \ud604\uc0c1\uc744 \ucd08\ub798\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\uc6a9\ucd9c\ubc95 \uc124\uacc4 \ubc0f \uac1c\ubc1c \uc2dc \uace0\ub824\ud574\uc57c \ud560 \ub450 \uac00\uc9c0 \ud575\uc2ec \uc694\uc18c\ub294 \uc6d0\ub8cc\uc758 \uc6a9\ud574\ub3c4\uc640 SGC\uc758 \uc6a9\uc561 \uc548\uc815\uc131\uc785\ub2c8\ub2e4. \uc801\uc808\ud55c \uc6a9\ucd9c \ub9e4\uccb4\ub97c \ud655\ub9bd\ud558\uae30 \uc704\ud574\uc11c\ub294 \uc5ec\ub7ec \uc6a9\ucd9c \ub9e4\uccb4\ub97c \ud3c9\uac00\ud558\uc5ec \uc801\uc808\ud55c \uc2f1\ud06c \uc870\uac74\uc744 \ucda9\uc871\ud558\ub294 \ub9e4\uccb4\ub97c \uc120\uc815\ud574\uc57c \ud569\ub2c8\ub2e4. \uc2f1\ud06c \uc870\uac74\uc740 \uc9c0\uc815\ub41c \uacc4\uba74\ud65c\uc131\uc81c\uc758 \uc591\uc744 \ucd5c\uc18c\ud654\ud558\uba74\uc11c, \uc6a9\ub9e4\uc758 \ubd80\ud53c\uac00 \uc6d0\ub8cc\uc758 \ud3ec\ud654 \uc6a9\ud574\ub3c4\uc758 \ucd5c\uc18c 3\ubc30 \uc774\uc0c1\uc778 \uc0c1\ud0dc\ub85c \uc815\uc758\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uc774\ub7ec\ud55c \uc5f0\uad6c\ub97c \ud1b5\ud574 \uc6a9\ucd9c \uc2dc\ud5d8\uacfc \uad00\ub828\ub41c \uc2dc\uac04 \ub0b4\uc5d0 \ucda9\uc804\uc7ac\ub97c \uc6a9\ud574\uc2dc\ud0a4\ub294 \ub370 \ud544\uc694\ud55c \uacc4\uba74\ud65c\uc131\uc81c\uc758 \uc591\uc744 \ucd5c\uc801\ud654\ud558\uace0 \uad00\ucc30\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uc6a9\ucd9c \uacb0\uacfc\uac00 \uc2f1\ud06c \uc870\uac74 \ud558\uc5d0\uc11c API\uc758 \ud2b9\uc131\uc744 \ubc18\uc601\ud558\ub294 \uac83\uc774 \ub354 \ud569\ub9ac\uc801\uc774\uc9c0\ub9cc, \uc2f1\ud06c \uc870\uac74\uc744 \ucda9\uc871\ud558\uc9c0 \ubabb\ud558\ub294 \uc6a9\ub9e4\ub77c\ub3c4 \uc801\uc808\ud55c \uadfc\uac70\uac00 \uc81c\uc2dc\ub41c\ub2e4\uba74 USP\uc5d0\uc11c \ud5c8\uc6a9\ud560 \uc218 \uc788\ub2e4. \ub9c8\ucc2c\uac00\uc9c0\ub85c \uc6a9\ub9e4\ub97c \uc120\ud0dd\ud560 \ub54c, \uc0b0 \ubc0f \uc5fc \ub18d\ub3c4, \uc644\ucda9\uc81c \ub300\uc774\uc628 \ubc0f \ubcf4\uc870 \uc6a9\ub9e4\uc640 \uac19\uc740 \ucca8\uac00\uc81c\uc758 \uc601\ud5a5\uacfc, \uc0ac\uc6a9\ub41c \uacbd\uc6b0 \ud6a8\uc18c\uc758 \uc885\ub958 \ubc0f \ud65c\uc131\ub3c4 \ud3c9\uac00\ud558\uace0 \uadf8 \uadfc\uac70\ub97c \uc81c\uc2dc\ud574\uc57c \ud55c\ub2e4. \uc6d0\ub8cc\uc758 \uc6a9\ud574\ub3c4 \ud5a5\uc0c1\uc740 \uacc4\uba74\ud65c\uc131\uc81c \ubc0f \ucda9\uc804\uc7ac\uc758 \uc131\uc9c8, \uc628\ub3c4, pH, \uc774\uc628 \uac15\ub3c4 \ub4f1 \ub2e4\uc591\ud55c \uc694\uc778\uc5d0 \ub530\ub77c \ub2ec\ub77c\uc9d1\ub2c8\ub2e4. \uc6a9\ucd9c \uc2e4\ud5d8\uc744 \uc218\ud589\ud558\uae30 \uc804\uc5d0 \ub2e4\uc591\ud55c \uacc4\uba74\ud65c\uc131\uc81c \ubc0f \ud654\ud569\ubb3c\uc5d0 \ub300\ud574 \uc774\ub7ec\ud55c \uad00\uacc4\ub97c \uc774\ud574\ud574\uc57c \ud569\ub2c8\ub2e4.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\uc6a9\ucd9c \uc2dc\ud5d8\uc5d0 \uc77c\ubc18\uc801\uc73c\ub85c \uc0ac\uc6a9\ub418\ub294 \uc6a9\ub9e4\ub85c\ub294 \ud76c\uc5fc\uc0b0(0.1 N), \uc0dd\ub9ac\ud559\uc801 pH \ubc94\uc704(1~7.5)\uc758 \uc644\ucda9\uc561(\uc989, \uc778\uc0b0\uc5fc, \uc544\uc138\ud2b8\uc0b0\uc5fc \ub610\ub294 \uad6c\uc5f0\uc0b0\uc5fc), \ubaa8\uc758 \uc704\uc561 \ub610\ub294 \uc7a5\uc561(\ud6a8\uc18c \ud3ec\ud568 \ub610\ub294 \ubbf8\ud3ec\ud568), \ubb3c, \uadf8\ub9ac\uace0 \ud2b8\uc708(Tween), \ube0c\ub9ac\uc9c0 35(Brij 35), \ud2b8\ub9ac\ud1a4(Triton), \ud3f4\ub9ac\uc18c\ub974\ubca0\uc774\ud2b8 80(Polysorbate 80), \uc138\ud2f8\ud2b8\ub9ac\uba54\ud2f8\uc554\ubaa8\ub284\ube0c\ub85c\ub9c8\uc774\ub4dc(CTAB), \ub77c\uc6b0\ub9b4\ud669\uc0b0\ub098\ud2b8\ub968(SLS), \ub2f4\uc999\uc0b0\uc5fc\uacfc \uac19\uc740 \uacc4\uba74\ud65c\uc131\uc81c \ub4f1\uc774 \uc788\uc2b5\ub2c8\ub2e4[100]. \uc77c\ubd80 SGC \uc81c\ud615\uc5d0\ub294 \ubb3c\uc774\ub098 \uc0b0\uc131 \ud658\uacbd\uc5d0\uc11c \uc6a9\ud574\ub418\uc9c0 \uc54a\uc544 \uacb0\uacfc\uc801\uc73c\ub85c \uc218\uc6a9\uc561\uc5d0\uc11c \uc2f1\ud06c(sink) \uc870\uac74\uc744 \ucda9\uc871\ud558\uc9c0 \ubabb\ud558\ub294 \ub9e4\ud2b8\ub9ad\uc2a4\ub098 API\uac00 \ud3ec\ud568\ub420 \uc218 \uc788\ub2e4. \uc774\ub7ec\ud55c \uacbd\uc6b0, \ud0c0\ub2f9\ud55c \ub18d\ub3c4\uc758 \uacc4\uba74\ud65c\uc131\uc81c\ub97c \uc6a9\ucd9c \ub9e4\uccb4\uc5d0 \ucca8\uac00\ud560 \uc218 \uc788\ub2e4. \uc6d0\ub8cc\uc758 \uc57d\uc81c\ud559\uc801 \uc548\uc815\uc131 \ubc0f \uc6a9\ud574\ub3c4\uc640 \uad00\ub828\ud558\uc5ec \uacc4\uba74\ud65c\uc131\uc81c\uc758 \uc120\ud0dd\uacfc \uadf8 \ub18d\ub3c4\ub294 \ub9e4\uc6b0 \uc911\uc694\ud558\uba70, \ucd5c\uc801\ud654\ub418\uace0, \uc774\ud574\ub418\uba70, \ud0c0\ub2f9\uc131\uc774 \uc785\uc99d\ub418\uc5b4\uc57c \ud55c\ub2e4. \uacc4\uba74\ud65c\uc131\uc81c\uc758 \ucca8\uac00\ub294 \uc81c\ud615\uc758 \ubcc0\ud654\uc640 \ucda9\uc804 \uc131\ubd84 \uac04\uc758 \uc0c1\ud638\uc791\uc6a9\uc744 \ubc18\uc601\ud574\uc57c \ud558\uba70, SGC\uc758 \uc0dd\uccb4 \ub0b4 \uac70\ub3d9\uc5d0 \ub300\ud55c \ud1b5\ucc30\uc744 \uc81c\uacf5\ud560 \uc218 \uc788\ub2e4.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\uacc4\uba74\ud65c\uc131\uc81c\ub294 \uc785\uc790 \ud45c\uba74\uc758 \ubb3c \ubd84\uc790\ub97c \ub300\uccb4\ud568\uc73c\ub85c\uc368 \uc6a9\ud574\uc5d0 \uae30\uc5ec\ud558\uba70, \uc774\ub85c \uc778\ud574 \uc6a9\uc561\uacfc \ud45c\uba74 \uc0ac\uc774\uc758 \uacc4\uba74 \uc7a5\ub825\uc774 \uac10\uc18c\ud55c\ub2e4 [101]. Amidon \ub4f1\uc740 \ub2f4\uc999\uc0b0\uc5fc, \ub808\uc2dc\ud2f4, \ucf5c\ub808\uc2a4\ud14c\ub864 \ubc0f \uadf8 \uc5d0\uc2a4\ud14c\ub974 \ub4f1 \ub2e4\uc591\ud55c \uacc4\uba74\ud65c\uc131\uc81c\uac00 \uc704\uc7a5\uc561\uc5d0 \uc874\uc7ac\ud558\uae30 \ub54c\ubb38\uc5d0 \uacc4\uba74\ud65c\uc131\uc81c\uac00 \ud3ec\ud568\ub41c \ub9e4\uccb4\ub97c \uc0ac\uc6a9\ud558\ub294 \uac83\uc774 \uc774\ub7ec\ud55c \uc57d\ubb3c\uc744 \uc6a9\ud574\uc2dc\ud0a4\ub294 \ub370 \uc801\ud569\ud55c \ubc29\ubc95\uc774\ub77c\uace0 \uc81c\uc548\ud588\ub2e4 [102]. \uacc4\uba74\ud65c\uc131\uc81c\ub294 \uce5c\uc218\uc131 \ubc0f \uc18c\uc218\uc131\uc774\ub77c\ub294 \ub450 \uac00\uc9c0 \ub69c\ub837\ud55c \uc131\ubd84\uc73c\ub85c \uad6c\uc131\ub418\uba70, \uce5c\uc218\uc131 \uadf8\ub8f9\uc758 \uc804\ud558\uc5d0 \ub530\ub77c \ub124 \uac00\uc9c0 \uadf8\ub8f9\uc73c\ub85c \ubd84\ub958\ub429\ub2c8\ub2e4: \uc74c\uc774\uc628\uc131(\uc608: \ub77c\uc6b0\ub9b4\ud669\uc0b0\ub098\ud2b8\ub968(SLS)), \uc591\uc774\uc628\uc131(\uc608: \uc138\ud2f8\ud2b8\ub9ac\uba54\ud2f8\uc554\ubaa8\ub284\ube0c\ub85c\ub9c8\uc774\ub4dc(CTAB)), \uc591\uc774\uc628-\uc74c\uc774\uc628\uc131(\uc608: \uc54c\ud0ac\ubca0\ud0c0\uc778) [101], \ubc0f \ube44\uc774\uc628\uc131(\uc608: \ud2b8\uc708 \ubc0f \ud2b8\ub9ac\ud1a4) [103,104]\uc73c\ub85c \ubd84\ub958\ub41c\ub2e4. \uc591\uc774\uc628\uc131 \uacc4\uba74\ud65c\uc131\uc81c\ub97c \ud568\uc720\ud55c \uc6a9\ucd9c \ub9e4\uccb4\ub294 \uc0b0\uc131 \ucda9\uc804\uc7ac\uc758 \uc6a9\ucd9c \uc18d\ub3c4\ub97c \ub354 \uc798 \uad6c\ubcc4\ud560 \uc218 \uc788\ub294 \ubc18\uba74, \uc74c\uc774\uc628\uc131 \uacc4\uba74\ud65c\uc131\uc81c\ub294 \uc5fc\uae30\uc131 \ucda9\uc804\uc7ac\uc758 \uc6a9\ucd9c \uc18d\ub3c4\ub97c \ub354 \uc798 \uad6c\ubcc4\ud55c\ub2e4. SLS\ub294 \uc6a9\ucd9c \uc5f0\uad6c\uc5d0\uc11c \uac00\uc7a5 \ud754\ud788 \uc0ac\uc6a9\ub418\ub294 \uacc4\uba74\ud65c\uc131\uc81c\ub85c \ubcf4\uace0\ub418\uc5c8\ub2e4 [100]. \uacc4\uba74\ud65c\uc131\uc81c\uc5d0 \uc758\ud55c \uc6a9\ud574\ub3c4 \ubc0f \uc6a9\ucd9c \uc18d\ub3c4 \uc99d\uac00\ub294 \uacc4\uba74\ud65c\uc131\uc81c \ub18d\ub3c4, \ubbf8\uc140\uc758 \ud06c\uae30 \ubc0f \uc548\uc815\uc131\uc5d0 \ub530\ub77c \ub2ec\ub77c\uc9c0\uba70, \uc774 \ubaa8\ub4e0 \uc694\uc18c\ub294 \uc784\uacc4 \ubbf8\uc140 \ub18d\ub3c4(CMC)\uc640 \uad00\ub828\uc774 \uc788\ub2e4 [105]. CMC\ub294 \uacc4\uba74\ud65c\uc131\uc81c \ub2e8\ub7c9\uccb4\uac00 \ubbf8\uc140\ub85c \uc751\uc9d1\ub418\ub294 \ucd5c\uc18c \ub18d\ub3c4\ub85c \uc815\uc758\ub418\uba70, \uac01 \uacc4\uba74\ud65c\uc131\uc81c\ub9c8\ub2e4 \uace0\uc720\ud55c \ud2b9\uc131\uc744 \uac00\uc9c4\ub2e4. \ud2b9\uc815 \uacc4\uba74\ud65c\uc131\uc81c\uc758 CMC \uac12\uc774 \ub0ae\uc744\uc218\ub85d \ubbf8\uc140\uc740 \ub354 \uc548\uc815\uc801\uc774\ub2e4 [106]. \ub610\ud55c, \uacc4\uba74\ud65c\uc131\uc81c\uc758 \ubd84\uc790 \uad6c\uc870\uc5d0 \ub300\ud55c \uc9c0\uc2dd\uc740 \ubbf8\uc140\uc758 \ud06c\uae30\uc5d0 \ub300\ud55c \uc815\ubcf4\ub97c \uc81c\uacf5\ud560 \uc218 \uc788\ub2e4.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\uc6a9\ucd9c \ub9e4\uccb4\uc5d0 \uacc4\uba74\ud65c\uc131\uc81c\ub97c \ucca8\uac00\ud558\uba74 \uc77c\ubd80 \uc758\uc57d\ud488\uc758 \uc6a9\ucd9c \uc18d\ub3c4\uac00 \uac10\uc18c\ud560 \uc218 \uc788\uc73c\uba70, \uacbd\uc6b0\uc5d0 \ub530\ub77c \uace0\uc131\ub2a5 \uc561\uccb4 \ud06c\ub85c\ub9c8\ud1a0\uadf8\ub798\ud53c(HPLC) \ubd84\uc11d \uc2dc \uc57d\ubb3c \ud53c\ud06c\uac00 \uc65c\uace1\ub420 \uc218\ub3c4 \uc788\ub2e4\ub294 \uc810\uc5d0 \uc720\uc758\ud574\uc57c \ud55c\ub2e4 ( ). \uc774\uc804 \uc5f0\uad6c[63]\uc5d0\uc11c, \ub09c\uc6a9\uc131 \uc57d\ubb3c\uc778 \ub85c\ub77c\ud0c0\ub518\uc744 \ud568\uc720\ud55c \uc989\uc2dc \ubc29\ucd9c\ud615 SGC\ub294 SLS\uac00 \uc874\uc7ac\ud560 \ub54c \ud53c\ud06c \uc65c\uace1\uc744 \ubcf4\uc778\ub2e4\ub294 \uc0ac\uc2e4\uc774 \ubc1d\ud600\uc84c\uc2b5\ub2c8\ub2e4. \ub2e4\ub978 \uc5f0\uad6c \uadf8\ub8f9\ub4e4[107,108]\uc5d0\uc11c\ub3c4 \ub0ae\uc740 pH \uc870\uac74\uc5d0\uc11c SLS\uac00 \uc824\ub77c\ud2f4 \ucea1\uc290\uc758 \uc6a9\ucd9c\uc744 \uac10\uc18c\uc2dc\ud0a8\ub2e4\ub294 \uc720\uc0ac\ud55c \uad00\ucc30 \uacb0\uacfc\uac00 \ubcf4\uace0\ub41c \ubc14 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\uc6a9\ucd9c \uc2dc\ud5d8\uc6a9 \ubaa8\uc758 \uc720\uccb4\ub97c \uac1c\ubc1c\ud558\ub824\uba74 \uc704\uc7a5\uad00(GIT)\uc758 \uc0dd\ub9ac\ud559\uc801 \uc870\uac74\uc744 \uc774\ud574\ud574\uc57c \ud569\ub2c8\ub2e4. \uc704\uc7a5\uad00\uc740 \uad6c\uc870\uac00 \ubcf5\uc7a1\ud558\uba70 \uc57d\ubb3c \ud761\uc218\uac00 \ubd80\uc704\uc5d0 \ub530\ub77c \ub2ec\ub77c\uc9c4\ub2e4\ub294 \uc810\uc744 \uc720\uc758\ud574\uc57c \ud569\ub2c8\ub2e4 [109]. \uc0dd\uccb4 \ub0b4 \uc6a9\ucd9c \uacfc\uc815\uc5d0 \uc601\ud5a5\uc744 \ubbf8\uce60 \uc218 \uc788\ub294 \uc5ec\ub7ec \uc0dd\ub9ac\ud559\uc801 \uc694\uc778\uc73c\ub85c\ub294 \uc704\uc561 \ubc0f \ub2f4\uc999 \ub0b4 \uacc4\uba74\ud65c\uc131\uc81c, \uc704\uc7a5 \ub0b4\uc6a9\ubb3c\uc758 \uc810\ub3c4, \uc704\uc7a5 \uc6b4\ub3d9 \ud328\ud134, \uc704\uc7a5 \ubd84\ube44\ubb3c, pH, \uc644\ucda9 \ub2a5\ub825, \uadf8\ub9ac\uace0 \uc561\uccb4\ub098 \uc74c\uc2dd\uc758 \ubcd1\uc6a9 \ud22c\uc5ec \ub4f1\uc774 \uc788\uc2b5\ub2c8\ub2e4 [110]. Vertzoni \ub4f1[111]\uc740 \uce5c\uc720\uc131 \ud654\ud569\ubb3c\uc758 \uc0dd\uccb4 \ub0b4 \uc6a9\ucd9c\uc5d0 \ub300\ud55c \uc704 \ub0b4\uc6a9\ubb3c\uc758 \uc911\uc694\uc131\uc744 \ud3c9\uac00\ud558\uae30 \uc704\ud574, pH 6.5\uc5d0\uc11c \ud0c0\uc6b0\ub85c\ucf5c\uc0b0\ub098\ud2b8\ub968, \ub808\uc2dc\ud2f4 \ubc0f \ud3a9\uc2e0\uc744 \ud568\uc720\ud55c \uacf5\ubcf5 \uc0c1\ud0dc \ubaa8\uc758 \uc704\uc561(FaSSGF)\uc744 \uac1c\ubc1c\ud588\ub2e4. \uc800\uc790\ub4e4\uc740 \uce5c\uc720\uc131 \uc57d\uc5fc\uae30\uc758 \ud761\uc218 \ud504\ub85c\ud30c\uc77c\uc744 \ud3c9\uac00\ud558\uae30 \uc704\ud574\uc11c\ub294 \uc704 \ub0b4\uc6a9\ubb3c\uc758 \uc2dc\ubbac\ub808\uc774\uc158\uc774 \ud544\uc218\uc801\uc774\ub77c\uace0 \uacb0\ub860\uc9c0\uc5c8\uc2b5\ub2c8\ub2e4. \uc77c\ubc18\uc801\uc778 \uc0dd\uccb4 \uad00\ub828 \uccb4\uc678 \uc6a9\ucd9c \ub9e4\uccb4\uc758 \uad6c\uc131\uc5d0 \ub300\ud55c \uac1c\uc694\ub294 Klein [112]\uacfc Galia \ub4f1 [113]\uc774 \uc81c\uc2dc\ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4. \ub9c8\ucc2c\uac00\uc9c0\ub85c, \uc2dc\ubbac\ub808\uc774\uc158\ub41c \uc6a9\ucd9c \ub9e4\uccb4\ub294 \uc704\uc7a5\uc561 \uc870\uc131\uc758 \ubc1c\ub2ec\uc801 \ubcc0\ud654\ub97c \uace0\ub824\ud574\uc57c \ud558\ub294\ub370, \uc774\ub294 \uc18c\uc544\uc640 \uc131\uc778 \uac04\uc758 \uad00\uac15 \ub0b4 \uc57d\ubb3c \uc6a9\ud574\ub3c4\uc5d0 \ucc28\uc774\ub97c \ucd08\ub798\ud560 \uc218 \uc788\uae30 \ub54c\ubb38\uc774\ub2e4. \ub530\ub77c\uc11c \uc18c\uc544\uacfc\uc5d0\uc11c \uc0dd\uccb4 \uad00\ub828 \uc6a9\ucd9c \ub9e4\uccb4\uc758 \uc870\uc131\uc744 \uc815\uc758\ud558\uae30 \uc704\ud574\uc11c\ub294 \uc704\uc7a5\uc561 \ub9e4\uac1c\ubcc0\uc218(\uc989, \ud3a9\uc2e0 \ub18d\ub3c4, \ub2f4\uc999\uc0b0, \uad00\uac15 \ub0b4 \uc810\ub3c4, pH, \uc0bc\ud22c\uc555 \ub4f1)\uc758 \uc5f0\ub839\ubcc4 \ubcc0\ud654\ub97c \ud3c9\uac00\ud558\ub294 \uac83\uc774 \ub9e4\uc6b0 \uc911\uc694\ud569\ub2c8\ub2e4 [114]. \ub610\ud55c, \uc704\uc0b0 \uacfc\uc18c\uc99d \ubc0f \ubb34\uc0b0\uc99d\uacfc \uac19\uc740 \uc9c8\ud658\uc774 \uc788\ub294 \uace0\ub839 \uc778\uad6c\ub294 \uc704 pH\uac00 \uc0c1\uc2b9\ud574 \uc788\uc2b5\ub2c8\ub2e4 [115]. \ub530\ub77c\uc11c, \uc774 \uc778\uad6c \uc9d1\ub2e8\uc5d0 \ub300\ud55c \ubaa8\uc758 \uc6a9\ucd9c \ub9e4\uccb4\ub294 \uc774\ub7ec\ud55c pH \uc0c1\uc2b9\uc744 \ubc18\uc601\ud558\ub3c4\ub85d \uc870\uc815\ub418\uc5b4\uc57c \ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\uc6a9\ucd9c \uc7a5\uce58\uc758 \uc120\uc815\uc740 SGC\uc758 \uc6a9\ucd9c \ud3c9\uac00\uc5d0\uc11c \ub610 \ub2e4\ub978 \uc911\uc694\ud55c \ub2e8\uacc4\uc785\ub2c8\ub2e4. \uc774\ub294 \ucda9\uc804\uc7ac\uc640 \uc6a9\ub9e4\uc758 \ud63c\ud569 \ud6a8\uc728\uc774 \uad50\ubc18 \uc720\uccb4\uc5ed\ud559, \ud2b9\ud788 \ud328\ub4e4 \ud68c\uc804 \uc18d\ub3c4\uc640 \uac19\uc740 \ubcc0\uc218\uc5d0 \ud06c\uac8c \uc601\ud5a5\uc744 \ubc1b\uae30 \ub54c\ubb38\uc785\ub2c8\ub2e4. SGC\uc758 \uc6a9\ucd9c \ud2b9\uc131\uc744 \ud3c9\uac00\ud558\ub294 \ub370 \uc77c\ubc18\uc801\uc73c\ub85c \uc0ac\uc6a9\ub418\ub294 \ub450 \uac00\uc9c0 \ubc29\ubc95\uc740 \ud328\ub4e4\ubc95\uacfc \ubc14\uc2a4\ucf13\ubc95\uc785\ub2c8\ub2e4.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\ubc14\uc2a4\ucf13 \uc7a5\uce58\ub294 SGC\ub97c \ubc00\ud3d0\ud560 \uc218 \uc788\ub2e4\ub294 \uc7a5\uc810\uc774 \uc788\ub2e4. SGC\uac00 \ubb3c\ubcf4\ub2e4 \ube44\uc911\uc774 \ub0ae\uc740 \ubb3c\uc9c8\ub85c \ucc44\uc6cc\uc9c4 \uacbd\uc6b0, \ubc14\uc2a4\ucf13\uc744 \uc0ac\uc6a9\ud558\uba74 SGC\uc640 \uadf8 \uad6c\uc131 \uc131\ubd84\uc774 \uc6a9\ub9e4 \uc18d\uc5d0\uc11c \ub728\ub294 \uac83\uc744 \ubc29\uc9c0\ud560 \uc218 \uc788\uc73c\ubbc0\ub85c \uc774 \ubc29\ubc95\uc744 \uc120\ud0dd\ud560 \uc218 \uc788\ub2e4. \ubc14\uc2a4\ucf13 \uc0ac\uc6a9 \uc2dc \ud754\ud788 \uad00\ucc30\ub418\ub294 \ubb38\uc81c \uc911 \ud558\ub098\ub294 \uc6a9\ud574 \uc2e4\ud5d8 \ub3c4\uc911 \uc5f0\uc9c8 \uac94 \uaecd\uc9c8\uc774 \ubd80\ub4dc\ub7fd\uace0 \ub048\uc801\ud55c \ub369\uc5b4\ub9ac\ub85c \ubd84\ud574\ub418\uc5b4 \ubc14\uc2a4\ucf13\uc758 \ub9dd\uc744 \ub9c9\uc744 \uc218 \uc788\uc73c\uba70, \uc774\ub85c \uc778\ud574 \uacb0\uacfc\uc5d0 \ud070 \ud3b8\ucc28\uac00 \ubc1c\uc0dd\ud560 \uc218 \uc788\ub2e4\ub294 \uc810\uc785\ub2c8\ub2e4. \ub610\ud55c, \ucda9\uc804\uc7ac\uac00 \uc18c\uc218\uc131, \uc989 \uc720\uc131 \ucda9\uc804\uc7ac\uc778 \uacbd\uc6b0, \ubc14\uc2a4\ucf13\uc758 \uba54\uc26c\ub97c \ud1b5\uacfc\ud560 \uc218 \uc788\ub294 \ubbf8\uc138\ud55c \uc561\uc801\ub85c\uc758 \ubd84\uc0b0\uc774 \uc77c\uc5b4\ub098\uc9c0 \uc54a\uc744 \uc218 \uc788\uc73c\uba70, \uc774\ub85c \uc778\ud574 SGC\uc758 \uc2e4\uc81c \ud2b9\uc131\uc744 \uc81c\ub300\ub85c \ubc18\uc601\ud558\uc9c0 \ubabb\ud558\ub294 \uc6a9\ud574 \uc9c0\uc5f0\uc774 \ubc1c\uc0dd\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uc774 \ubb38\uc81c\ub97c \uc644\ud654\ud558\uae30 \uc704\ud55c \ub300\uc548\uc73c\ub85c\ub294 \uae30\uacf5\uc774 \ub354 \ud070 \ubc14\uc2a4\ucf13, \uc989 20 \ub610\ub294 10 \uba54\uc26c \ud06c\uae30\uc758 \ubc14\uc2a4\ucf13\uc744 \uc0ac\uc6a9\ud558\ub294 \uac83\uc774 \uc788\uc2b5\ub2c8\ub2e4 [116]. Pillay\uc640 Fassihi\ub294 \ud68c\uc804 \ubc14\uc2a4\ucf13\ubc95\uc744 \uc0ac\uc6a9\ud558\uc5ec \ub2c8\ud398\ub514\ud540\uc758 \uc9c0\uc9c8 \uae30\ubc18 SGC\uc758 \uc6a9\ucd9c\uc744 \ud3c9\uac00\ud588\uc2b5\ub2c8\ub2e4. \uadf8\ub4e4\uc758 \ub370\uc774\ud130\uc5d0 \ub530\ub974\uba74, 6\uc2dc\uac04\uc758 \uc6a9\ucd9c \uc2dc\ud5d8 \ud6c4\uc5d0\ub3c4 \uc810\uc131\uc774 \ub192\uc740 \uc720\uc131 \ucda9\uc804 \uc81c\ud615\uc758 \ub300\ubd80\ubd84\uc774 \uc5ec\uc804\ud788 \ubc14\uc2a4\ucf13 \ub0b4\uc5d0 \uc5bd\ud600 \uc788\uc5b4 \uc6a9\ucd9c \uc2e4\ud328\ub85c \uc774\uc5b4\uc84c\uc2b5\ub2c8\ub2e4 [55]. \uc774\ub294 40\uba54\uc26c \ud06c\uae30\uc758 \ud45c\uc900 \uc6a9\ucd9c \ubc14\uc2a4\ucf13\uc744 \uc0ac\uc6a9\ud588\uace0, \ubc14\uc2a4\ucf13 \ub0b4\ubd80\uc758 \uc720\uccb4 \uc5ed\ud559\uc801 \uc870\uac74\uc774 \ubd80\uc801\uc808\ud588\uae30 \ub54c\ubb38\uc73c\ub85c \ubd84\uc11d\ub418\uc5c8\ub2e4. \uadf8\ub7ec\ub098 \uc7ac\uc124\uacc4\ub41c \uc6a9\ucd9c \uc7a5\uce58\ub97c \uc0ac\uc6a9\ud558\uc5ec \uc6a9\ucd9c \uc2dc\ud5d8\uc744 \ubc18\ubcf5\ud588\uc744 \ub54c, \ub2c8\ud398\ub514\ud540 SGC\ub294 \ucd5c\uc0c1\uc758 \uc6a9\ucd9c \ud504\ub85c\ud30c\uc77c\uc744 \ubcf4\uc600\ub2e4.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\ud328\ub4e4 \ubc29\uc2dd\uc740 FDA \uc2b9\uc778\uc744 \ubc1b\uc740 \uc2dc\ud310 \uc758\uc57d\ud488\uc5d0\uc11c \uc0ac\uc6a9\ub418\ub294 \uc6a9\ucd9c \uc2dc\ud5d8 \ubc29\ubc95\uc758 \uc57d 70%\ub97c \ucc28\uc9c0\ud55c\ub2e4 [100]. \uc774 \ubc29\ubc95\uc740 \ucea1\uc290\uc744 \ub2f4\ub294 \uba54\uc26c \ubc14\uc2a4\ucf13\uc744 \uc0ac\uc6a9\ud558\uc9c0 \uc54a\uae30 \ub54c\ubb38\uc5d0, \ucea1\uc290\uc774 \ud30c\uc5f4\ub418\uba74 SGC\uac00 \uc6a9\ucd9c \ub9e4\uc9c8 \ud45c\uba74\uc73c\ub85c \ub5a0\uc624\ub974\ub294 \ud604\uc0c1\uc774 \ud754\ud788 \ubc1c\uc0dd\ud558\ub294 \ucd08\uae30 \ubb38\uc81c\uc810\uc774\ub2e4. \uc774\ub7ec\ud55c \uacbd\uc6b0, \uc2f1\ucee4(sinkers)\ub77c\uace0\ub3c4 \ubd88\ub9ac\ub294 \uc640\uc774\uc5b4 \ucf54\uc77c\uc744 \uc0ac\uc6a9\ud558\uc5ec \uc18c\ud504\ud2b8 \uc824\uc744 \uac10\uc2f8\uace0 \uc6a9\uae30 \ubc14\ub2e5\uc5d0 \uace0\uc815\uc2dc\ud0ac \uc218 \uc788\ub2e4[117]. \uc774\ub97c \ud1b5\ud574 (\ucea1\uc290 \uc678\ud53c\uac00 \ud30c\uc5f4\ub418\uc5c8\uc744 \ub54c) \ub0b4\uc6a9\ubb3c\uc774 \uc6a9\ub9e4\uc5d0 \ub354 \uc798 \ub178\ucd9c\ub420 \uc218 \uc788\uc73c\uba70, \ucea1\uc290\uc774 \uc6a9\uae30 \ubcbd\uba74\uc5d0 \ub2ec\ub77c\ubd99\ub294 \uac83\uc744 \ubc29\uc9c0\ud558\ub294 \ub370 \ub3c4\uc6c0\uc774 \ub41c\ub2e4. \uc2f1\ucee4\uc758 \ubaa8\uc591\uacfc \ud06c\uae30\ub294 \uc6a9\ucd9c \uacfc\uc815\uc5d0 \uc601\ud5a5\uc744 \ubbf8\uce60 \uc218 \uc788\uc73c\ubbc0\ub85c, \ud2b9\ud788 SGC\uac00 \uc6a9\ucd9c \ub9e4\uc9c8\uacfc \uc811\ucd09\ud588\uc744 \ub54c \ud33d\ucc3d\ud558\ub294 \uacbd\uc6b0 \uc2e0\uc911\ud558\uac8c \uc120\ud0dd\ud574\uc57c \ud55c\ub2e4. \uc774\uc804 \uc5f0\uad6c\uc5d0\uc11c \ud328\ub4e4\ubc95\uc744 \uc0ac\uc6a9\ud558\uc5ec \uc5bb\uc740 \uc6a9\ucd9c \uc18d\ub3c4\ub294 \ubc14\uc2a4\ucf13\ubc95\uc744 \uc0ac\uc6a9\ud558\uc5ec \uc5bb\uc740 \uc18d\ub3c4\ubcf4\ub2e4 \ube60\ub974\uba70, \ucd08\uae30 \uc2dc\uac04\ub300\uc5d0\uc11c \ubcc0\ub3d9\uc131\uc774 \ud070 \uac83\uc73c\ub85c \ub098\ud0c0\ub0ac\ub2e4. \ubc18\uba74, \ubc14\uc2a4\ucf13 \uc6a9\ucd9c \uc7a5\uce58\ub97c \uc0ac\uc6a9\ud558\uc5ec \uc218\uc9d1\ud55c \ub370\uc774\ud130\ub294 \uc774 \ubc29\ubc95\uc774 \ub354 \uc120\ud0dd\uc801\uc774\uba70 API \ubc29\ucd9c \ud504\ub85c\ud30c\uc77c \uce21\uba74\uc5d0\uc11c \ubcc0\ub3d9\uc131\uc774 \uc801\uc74c\uc744 \ubcf4\uc5ec\uc8fc\uc5c8\ub2e4 [63]. \ud45c\ub294 \uc2dc\ud310\ub418\ub294 SGC\uc758 \uc608\uc640 \uadf8 \uc6a9\ucd9c \ubc29\ubc95\uc744 \ubcf4\uc5ec\uc900\ub2e4. \ub2e4\ub978 \uc5f0\uad6c \uadf8\ub8f9\ub4e4\uc740 SGC\uc758 \uc6a9\ucd9c \ud3c9\uac00\uc5d0 USP III\ub97c \uc0ac\uc6a9\ud558\ub294 \ud0c0\ub2f9\uc131\uc744 \ud3c9\uac00\ud588\ub2e4. Monterroza\uc640 Ponce De Le\u00f3n [118]\uc740 \ubbf8\ubd84\ud654\ub41c \ud504\ub85c\uac8c\uc2a4\ud14c\ub860\uc758 \uc720\uc131 \ud604\ud0c1\uc561\uc744 \ud568\uc720\ud55c SGC\uc5d0 \ub300\ud55c \ucc28\ubcc4\ud654\ub41c \uc6a9\ucd9c \ubc29\ubc95\uc744 \uac1c\ubc1c\ud588\ub2e4. \uadf8\ub4e4\uc740 USP 1, 2 \ubc0f 3\uc744 \uc0ac\uc6a9\ud558\uc5ec \uc0dd\uc131\ub41c \uc6a9\ucd9c \ud504\ub85c\ud30c\uc77c\uc744 \ube44\uad50\ud588\uc2b5\ub2c8\ub2e4. \uc608\ube44 \uc2dc\ud5d8 \uacb0\uacfc, USP 1 \ubc0f USP 2 \ubc29\ubc95\uc740 90\ubd84 \uc774\ub0b4\uc5d0 85% \uc774\uc0c1\uc758 API\ub97c \ubc29\ucd9c\ud55c\ub2e4\ub294 \ubaa9\ud45c\ub97c \ub2ec\uc131\ud558\uc9c0 \ubabb\ud588\uc2b5\ub2c8\ub2e4. \uadf8\ub7ec\ub098 USP 3\uc740 pH 6.8 \uc778\uc0b0\uc5fc \uc6a9\uc561\uc5d0 250mL\uc758 4% SLS\uac00 \uc874\uc7ac\ud558\ub294 \uc870\uac74\uc5d0\uc11c 90\ubd84 \uc774\ub0b4\uc5d0 85% \uc774\uc0c1\uc758 API\ub97c \ubc29\ucd9c\ud560 \uc218 \uc788\ub294 \uc720\ub9dd\ud55c \uc804\ub9dd\uc744 \ubcf4\uc5ec\uc8fc\uc5c8\uc2b5\ub2c8\ub2e4.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">&nbsp;<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\ucf54\ud305\ub41c SGC\uc640 \uac19\uc740 \uc77c\ubd80 \uacbd\uc6b0\uc5d0\ub294 2\ub2e8\uacc4 \ub610\ub294 2\ub2e8\uacc4 \uc6a9\ucd9c \uae30\ubc95\uc744 \uac1c\ubc1c\ud574\uc57c \ud55c\ub2e4 [120,121,122]. \uc774 \ubc29\ubc95\uc758 \ubaa9\uc801\uc740 \uc704\uc0b0\uc758 \uc0b0\uc131 \uc870\uac74\uc5d0\uc11c \ucf54\ud305\uc758 \ubb34\uacb0\uc131\uc744 \ud3c9\uac00\ud558\uace0, pH\uac00 \uc911\uc131\uc5d0 \uac00\uae4c\uc6b4 \uc704\uc7a5\uad00 \ud558\ubd80\uc5d0\uc11c \uc57d\ubb3c \ubc29\ucd9c\uc744 \uce21\uc815\ud558\ub294 \uac83\uc785\ub2c8\ub2e4. 2\ub2e8\uacc4 \uc6a9\ucd9c \uc2dc\ud5d8\uc744 \uc218\ub3d9\uc73c\ub85c \uc218\ud589\ud558\ub294 \uac83\uc740 \ub178\ub3d9 \uc9d1\uc57d\uc801\uc774\uba70, \uc798 \ud6c8\ub828\ub41c \ubd84\uc11d\uac00\uac00 \ud544\uc694\ud569\ub2c8\ub2e4. \uc608\ub97c \ub4e4\uc5b4, \ub450 \ubc88\uc9f8 \uc6a9\ub9e4\ub97c \uc608\uc5f4\ud558\uace0, \ub450 \ubc88\uc9f8 \uc6a9\uc561\uc744 \ucca8\uac00\ud558\uc5ec \uc6a9\ub9e4\ub97c \uc870\uc815\ud558\uba70, 5\ubd84 \uc774\ub0b4\uc5d0 6\uac1c\uc758 \uc6a9\uae30\uc5d0 \ub300\ud574 pH\ub97c \uc870\uc815\ud558\uace0 \ud655\uc778\ud574\uc57c \ud569\ub2c8\ub2e4. \uc77c\ubc18\uc801\uc73c\ub85c \uc6a9\ub9e4 \uc218\uc815\uc5d0\ub294 \uc6a9\ub9e4 \ucca8\uac00(medium-addition)\uc640 \uc6a9\ub9e4 \uad50\ud658(medium-exchange)\uc774\ub77c\ub294 \ub450 \uac00\uc9c0 \uc811\uadfc \ubc29\uc2dd\uc774 \uc788\uc2b5\ub2c8\ub2e4. \uc608\ub97c \ub4e4\uc5b4, \ub450 \uc811\uadfc\ubc95 \ubaa8\ub450 0.1N \uc5fc\uc0b0\uacfc \uac19\uc740 \uc0b0\uc131 \ub2e8\uacc4\ub85c \uc77c\uc815 \uae30\uac04 \uc2dc\uc791\ud55c \ud6c4, pH 6.8\uc758 \uc778\uc0b0\uc5fc \uc644\ucda9\uc561\uacfc \uac19\uc740 \uc644\ucda9 \ub2e8\uacc4\ub85c \uc774\uc5b4\uc9c8 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uad6c\uccb4\uc801\uc778 \uc2dc\uac04\uc740 \uac1c\ubcc4 \uc758\uc57d\ud488\uc5d0 \ub530\ub77c \ud544\uc694\uc5d0 \ub9de\uac8c \uc120\ud0dd\ub429\ub2c8\ub2e4. \ub450 \ubc29\ubc95 \uc911 \uc5b4\ub290 \uac83\uc744 \uc0ac\uc6a9\ud558\ub4e0, pH \uc870\uc815\uc740 \uc608\uc5f4\ub41c \ubc30\uc9c0\ub97c \ud1b5\ud574 \uc81c\uc5b4\ub418\uace0 \uc7ac\ud604 \uac00\ub2a5\ud55c \ubc29\uc2dd\uc73c\ub85c \uc218\ud589\ub418\uc5b4\uc57c \ud569\ub2c8\ub2e4. \uc6a9\uc561 \ucca8\uac00 \ubc0f pH \uc870\uc815 \uc791\uc5c5\uc740 5\ubd84 \uc774\ub0b4\uc5d0 \uc644\ub8cc\ub418\uc5b4\uc57c \ud569\ub2c8\ub2e4 [123]. Zhao\uc640 \ub3d9\ub8cc\ub4e4\uc740 \uc6a9\ub9e4 \ucca8\uac00 \ubc0f \ud328\ub4e4 \uc7a5\uce58\ub97c \uc0ac\uc6a9\ud558\ub294 2\ub2e8\uacc4 \uc6a9\ucd9c\ubc95\uc744 \uae30\uc220\ud588\ub294\ub370, \uc774 \ubc29\ubc95\uc5d0\uc11c\ub294 1\ub2e8\uacc4\uc5d0\uc11c API\uc758 \uc6a9\ud574\ub3c4\ub97c \ub192\uc774\uae30 \uc704\ud574 \uc6a9\ub9e4\uc5d0 \uacc4\uba74\ud65c\uc131\uc81c Tween 80\uc744 \ud3ec\ud568\uc2dc\ucf30\ub2e4 [124]. \uac1c\ubc1c\ub41c \uc6a9\ucd9c\ubc95\uc740 \uc758\uc57d\ud488\uc758 \uc870\uc131, \uc81c\uc870 \uacf5\uc815 \ubc0f \uc548\uc815\uc131\uc758 \ubcc0\ud654\ub97c \uad6c\ubcc4\ud560 \uc218 \uc788\uc5c8\ub2e4. 2\ub2e8\uacc4 \uc6a9\ucd9c \uc808\ucc28\ub97c \uac1c\ubc1c\ud560 \ub54c\ub294 \uc801\uc808\ud55c \uc6a9\ub9e4\ub97c \ud655\ub9bd\ud558\uae30 \uc704\ud574 \uc5ec\ub7ec \uc694\uc778\uc744 \uc2e0\uc911\ud558\uac8c \uac80\ud1a0\ud574\uc57c \ud55c\ub2e4. \uac00\uc7a5 \uc911\uc694\ud55c \ub2e8\uacc4\ub294 \ub2e4\uc591\ud55c \uc6a9\ub9e4\ub97c \uc2e0\uc911\ud558\uac8c \ud3c9\uac00\ud558\uc5ec \uc2f1\ud06c \uc870\uac74\uc744 \ub2ec\uc131\ud558\ub294 \uc6a9\ub9e4\ub97c \ud655\uc778\ud558\ub294 \uac83\uc774\ub2e4. \ucda9\uc804\uc81c\uc758 \uc6a9\ud574\ub3c4\ub294 pH\uc5d0 \ub530\ub77c \ub2ec\ub77c\uc9c8 \uc218 \uc788\uc73c\ubbc0\ub85c, \uc0b0\uc131 \ubc0f \uc911\uc131 \uc6a9\ub9e4 \ubaa8\ub450\uc5d0\uc11c \ud654\ud569\ubb3c\uc758 \uc6a9\ud574\ub3c4\ub97c \ud3c9\uac00\ud574\uc57c \ud55c\ub2e4. \uc608\ub97c \ub4e4\uc5b4, 0.1 N HCl \ubc0f 50 mM pH 6.8 \uc778\uc0b0\uc5fc \uc644\ucda9\uc561\uc774 \uc77c\ubc18\uc801\uc73c\ub85c \uc0ac\uc6a9\ub418\ub294 \uc6a9\ub9e4\uc774\ub2e4.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\uc7a5\uc6a9 \ucf54\ud305 \ucea1\uc290\uc758 2\ub2e8\uacc4 \uc6a9\ucd9c \uc2dc\ud5d8\uc774\ub098 2\ub2e8\uacc4 \uc6a9\ucd9c \uc2dc\ud5d8\uc5d0 \uc0ac\uc6a9\ub418\ub294 \uc6a9\ub9e4 \ucca8\uac00 \uae30\ubc95\uc740 \ud328\ub4e4 \ub610\ub294 \ubc14\uc2a4\ucf13 \uc7a5\uce58\ub97c \ud65c\uc6a9\ud55c\ub2e4. \uc774 \ubc29\uc2dd\uc740 \uac01 \uc6a9\uae30\uc5d0 \ube44\uad50\uc801 \uc18c\ub7c9\uc758 \uc6a9\ub9e4\ub97c \uc9e7\uc740 \uc2dc\uac04 \ub0b4\uc5d0 \ucca8\uac00\ud574\uc57c \ud55c\ub2e4. \uc77c\ubc18\uc801\uc73c\ub85c \uc0ac\uc6a9\ub418\ub294 \uc6a9\ucd9c \uc6a9\ub7c9\uc740 500~1000mL \ubc94\uc704\uc774\uba70, FDA \uc2b9\uc778 \uc758\uc57d\ud488\uc5d0\uc11c\ub294 900mL\uac00 \uac00\uc7a5 \ud754\ud788 \uc0ac\uc6a9\ub41c\ub2e4[100]. \uadf8\ub7ec\ub098 \uc6a9\ucd9c \uc6a9\ub7c9\uc740 \uc2f1\ud06c \uc870\uac74\uc5d0 \ub530\ub77c \uc815\uc758\ub418\uc5b4\uc57c \ud55c\ub2e4. \ud488\uc9c8 \uad00\ub9ac\ub85c \uc774\uad00\ud560 \uc218 \uc788\ub294 \uacac\uace0\ud55c 2\ub2e8\uacc4 \uc6a9\ucd9c\ubc95\uc744 \uac1c\ubc1c\ud558\uae30 \uc704\ud574\uc11c\ub294, \uc608\ub97c \ub4e4\uc5b4 700mL\uc758 \ucd08\uae30 \uc6a9\uc801\uc5d0 200mL\uc758 \uc6a9\ub9e4\ub97c \ucca8\uac00\ud558\uc5ec pH\ub97c \uc870\uc815\ud55c \ud6c4, \uc5f0\uc9c8 \uc824\ub77c\ud2f4 \ucea1\uc290 \uc758\uc57d\ud488\uc758 \ud2b9\uc131\uc5d0 \ub530\ub77c \uacc4\uba74\ud65c\uc131\uc81c\ub098 \ud6a8\uc18c\ub97c \ucca8\uac00\ud558\ub294 \ubc29\uc2dd\uc774 \uc120\ud638\ub41c\ub2e4 [124]. \ub610\ud55c, \ubd80\ud53c \uc624\ucc28\uac00 \ubc1c\uc0dd\ud558\uc9c0 \uc54a\ub3c4\ub85d \uc815\ud655\ud55c \uc591\uc758 \uc6a9\ub9e4\ub97c \ucca8\uac00\ud574\uc57c \ud55c\ub2e4. \ub9c8\ucc2c\uac00\uc9c0\ub85c, \uc6a9\ub9e4 \ucca8\uac00 \uc2dc \ucd5c\uc885 \uc6a9\uc801\uc758 \ubaa9\ud45c pH\ub97c \uace0\ub824\ud574\uc57c \ud55c\ub2e4. \uc774 \uae30\ubc95\uc740 SGC\uc5d0 \ub300\ud55c \uce68\uc2b5\uc131\uc774 \uc801\uc73c\uba70, \ub2e4\uc911 \ubc30\uce58 \uc2e4\ud5d8 \uc2dc \uc9e7\uc740 \uc2dc\uac04 \ub0b4\uc5d0 \uc218\ud589\ud558\uae30 \uc6a9\uc774\ud558\ub2e4. \ub610\ud55c \uc774 \ubc29\ubc95\uc740 \ub178\ub3d9 \uc9d1\uc57d\ub3c4\uac00 \ub0ae\uc73c\uba70, \uc2e4\ud5d8 \uc9c4\ud589 \uc911 \ub354 \ub192\uc740 \uc2dc\ub8cc \ucc44\ucde8 \ucc98\ub9ac\ub7c9\uc744 \uac00\ub2a5\ud558\uac8c \ud55c\ub2e4. \uc7a5\uc6a9 \ucf54\ud305 \uc81c\uc81c\uc5d0 \uc801\uc6a9\ud560 \uacbd\uc6b0, \ucf54\ud305 \uacb0\ud568\uc744 \uac10\uc9c0\ud560 \uc218 \uc788\ub3c4\ub85d \uc6d0\ub8cc\uc758\uc57d\ud488(API)\uc740 \uccab \ubc88\uc9f8 \ub2e8\uacc4\uc758 \ubc30\uc9c0\uc5d0\uc11c \uaddc\uaca9 \uc218\uc900\uae4c\uc9c0 \uc6a9\ud574\ub418\uc5b4\uc57c \ud55c\ub2e4. \uc608\ub97c \ub4e4\uc5b4, 1\ub2e8\uacc4\uc758 \uaddc\uaca9 \uc218\uc900\uc774 10% \uc774\ud558 \ubc29\ucd9c\uc778 \uacbd\uc6b0, \uc774 \uc6a9\ub9e4\ub294 \uc18c\ud504\ud2b8 \uc824\ub77c\ud2f4 \ucea1\uc290 \uc81c\ud615 \ub0b4\uc758 \ud65c\uc131 \uc131\ubd84 \uc911 \ucd5c\uc18c 10%\ub97c \uc6a9\ud574\ud560 \uc218 \uc788\uc5b4\uc57c \ud55c\ub2e4. \ucda9\uc804\uc7ac\uac00 1\ub2e8\uacc4 \uc6a9\ub9e4\uc5d0 \uc6a9\ud574\ub418\uc9c0 \uc54a\ub294 \uacbd\uc6b0, \uacc4\uba74\ud65c\uc131\uc81c\ub97c \ucca8\uac00\ud558\uc5ec \ucda9\uc804\uc7ac \ub0b4\uc758 \ud65c\uc131 \uc131\ubd84 10% \uc774\uc0c1\uc744 \uc6a9\ud574\uc2dc\ud0ac \uc218 \uc788\uc2b5\ub2c8\ub2e4 [124]. 2\ub2e8\uacc4 \uc6a9\ud574 \uc2dc\ud5d8\uc5d0 \uc0ac\uc6a9\ud558\ub824\uba74, \ucda9\uc804\uc7ac\uc5d0 \uc6a9\ud574\ub3c4 \uc694\uac74\uc744 \ucda9\uc871\ud558\uae30 \uc704\ud574 \uacc4\uba74\ud65c\uc131\uc81c\uac00 \ud3ec\ud568\ub418\uc5b4\uc57c \ud560 \ubfd0\ub9cc \uc544\ub2c8\ub77c, \uac00\uad50\ub97c \uadf9\ubcf5\ud558\uae30 \uc704\ud574 \ud6a8\uc18c\ub3c4 \ud3ec\ud568\ub418\uc5b4\uc57c \ud569\ub2c8\ub2e4.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\uc7a5\uc6a9 \ucf54\ud305 \ucea1\uc290\uc5d0 \uc0ac\uc6a9\ub418\ub294 \ubc30\uc9c0 \uad50\ud658 \ubc29\uc2dd\uc758 \uacbd\uc6b0, \uccab \ubc88\uc9f8 \ub2e8\uacc4\uac00 \ub05d\ub098\uba74 \uc0b0\uc131 \ubc30\uc9c0\ub97c \ubc30\ucd9c\ud558\uace0, \ub3d9\uc77c\ud55c \uc870\uac74\uc5d0\uc11c \ud3c9\ud615 \uc0c1\ud0dc\ub97c \uc774\ub8ec pH 6.8 \uc644\ucda9\uc561\uc744 \uc804\uccb4 \uc6a9\ub7c9\ub9cc\ud07c \ub3d9\uc77c\ud55c \uc6a9\uae30\uc5d0 \ub123\uc5b4 \uc644\ucda9 \ub2e8\uacc4\ub85c \uc9c4\ud589\ud569\ub2c8\ub2e4. \ubc30\uc9c0 \uad50\ud658 \uacfc\uc815 \uc911\uc5d0\ub294 \uc81c\ud615\uc5d0 \uc5b4\ub5a0\ud55c \ubcc0\ud654\ub3c4 \uc8fc\uc5b4\uc11c\ub294 \uc548 \ub429\ub2c8\ub2e4. \uc644\uc804 \ub9e4\uccb4 \uad50\uccb4\ubc95\uc740 \ucea1\uc290\uc744 \uba3c\uc800 \uc0b0\uc131 \ub9e4\uccb4\uc5d0 \ud22c\uc785\ud55c\ub2e4\ub294 \uc810\uc5d0\uc11c \ub9e4\uccb4 \ucd94\uac00 \ubc29\uc2dd\uacfc \uc720\uc0ac\ud569\ub2c8\ub2e4. \uccab \ubc88\uc9f8 \ub2e8\uacc4\uac00 \ub05d\ub098\uba74 \ubd84\uc11d\uc744 \uc704\ud55c \uc2dc\ub8cc\ub97c \ucc44\ucde8\ud55c \ud6c4, \uc81c\ud615\uc744 \uc0b0\uc131 \uc870\uac74\uc5d0\uc11c \uc81c\uac70\ud569\ub2c8\ub2e4. \uc81c\ud615 \uc81c\uac70 \uae30\uc220\uc740 \uc6a9\ucd9c \uc7a5\uce58\uc758 \uc720\ud615\uc5d0 \ub530\ub77c \ub2e4\ub985\ub2c8\ub2e4. \uc81c\ud615\uc740 \ud55c \uc6a9\uae30\uc5d0\uc11c \ub2e4\ub978 \uc6a9\uae30\ub85c \uc218\ub3d9\uc73c\ub85c \uc62e\uae38 \uc218 \uc788\ub2e4. \ub610\ub294 \uc0b0\uc774 \ub4e4\uc5b4 \uc788\ub294 \uc6a9\uae30 \uc804\uccb4\ub97c \uc81c\uac70\ud558\uace0 \uc644\ucda9\uc561\uc774 \ub4e4\uc5b4 \uc788\ub294 \ub2e4\ub978 \uc6a9\uae30\ub85c \uad50\uccb4\ud55c \ud6c4, \uc81c\ud615\uc744 \uc0c8\ub85c\uc6b4 \uc6a9\uae30\ub85c \uc62e\uae38 \uc218\ub3c4 \uc788\ub2e4. SGC \uc81c\ud615\uc758 \ud488\uc9c8\uc740 \uc0b0\uc131 \ub2e8\uacc4\uc5d0 \ub300\ud55c USP \uc2b9\uc778 \uae30\uc900\uc744 \ucda9\uc871\ud568\uc73c\ub85c\uc368 \ubcf4\uc7a5\ub418\uba70, \uc989 \uac1c\ubc1c\ub41c \uc6a9\ucd9c \uae30\ubc95\uc758 \uccab \ubc88\uc9f8 \ub2e8\uacc4 \ub3d9\uc548 \uc758\uc57d\ud488\uc5d0\uc11c 10% \ubbf8\ub9cc\uc758 API\uac00 \uc6a9\ucd9c\ub418\uc5b4\uc57c \ud558\uba70, \ub530\ub77c\uc11c \ucf54\ud305\uc740 \uc0b0\uc131 \ub2e8\uacc4 \uc2dc\ud5d8\uc744 \ud1b5\uacfc\ud55c \uac83\uc73c\ub85c \uac04\uc8fc\ub41c\ub2e4. \uc644\ucda9\uc561 \ub2e8\uacc4\uc5d0\uc11c \uac01 \ub2e8\uc704 \ubc29\ucd9c\ub7c9\uc774 Q + 5% \uc774\uc0c1\uc778 \uacbd\uc6b0, \uc18c\ud504\ud2b8 \uc824 \uc81c\ud615\uc740 \uc6a9\ucd9c\uc758 \ub450 \ubc88\uc9f8 \ub2e8\uacc4\ub97c \ud1b5\uacfc\ud55c \uac83\uc73c\ub85c \uac04\uc8fc\ub429\ub2c8\ub2e4 [125]. Q\ub294 \uc6a9\ucd9c \ub9e4\uc9c8\uc5d0 \uc6a9\ucd9c\ub41c \uc720\ud6a8 \uc131\ubd84\uc758 \uc591\uc744 \ub098\ud0c0\ub0b4\uba70, \ud45c\uae30\ub41c \ud568\ub7c9\uc758 \ubc31\ubd84\uc728\ub85c \ud45c\uc2dc\ub429\ub2c8\ub2e4. 2\ub2e8\uacc4 \uc6a9\ucd9c \uc2dc\ud5d8 \uc911 \uc644\ucda9 \uc6a9\uc561\uc744 \ucd94\uac00\ud558\uace0 pH\ub97c \uc870\uc815\ud558\ub294 \uc218\uc791\uc5c5\uc758 \uc5b4\ub824\uc6c0\uc744 \uadf9\ubcf5\ud558\uae30 \uc704\ud574, \ub2e4\ub978 \uc5f0\uad6c \uadf8\ub8f9\ub4e4\uc740 \uc774\ub7ec\ud55c \uce21\uc815\uc744 \uc704\ud55c \ubc18\uc790\ub3d9 \uc6a9\ucd9c \uc2dc\uc2a4\ud15c\uc744 \uac1c\ubc1c\ud588\uc2b5\ub2c8\ub2e4 [125]. \ub9e4\uccb4 \uad50\ud658 \uae30\ubc95\uc740 SGC(\uc5f0\uc9c8 \ucea1\uc290)\uc758 \uacbd\uc6b0, \ud2b9\ud788 \ucea1\uc290\uc774 \uc561\uccb4\uc5d0 \ub178\ucd9c\ub418\uc5b4 \uc5f0\ud654\ub41c \uacbd\uc6b0 \uc801\uc6a9\ud558\uae30 \uc5b4\ub835\ub2e4. \ub2e8\uc21c\ud788 \ub2f4\uadf8\ub294 \uac83\ub9cc\uc73c\ub85c\ub3c4 \uc5b4\ub290 \uc815\ub3c4 \uc5f0\ud654\uac00 \ubc1c\uc0dd\ud558\uc9c0\ub9cc \ucea1\uc290\uc774 \ud30c\uc5f4\ub418\uc9c0\ub294 \uc54a\uc744 \uc218 \uc788\ub2e4. \ub530\ub77c\uc11c \uae30\uacc4\uc801 \uc751\ub825\uc73c\ub85c \uc778\ud574 \ucea1\uc290\uc744 \uc62e\uae30\uac70\ub098 \uaecd\uc9c8\uc744 \uc190\uc0c1\uc2dc\ud0a4\uc9c0 \uc54a\uace0 \ub9e4\uccb4\ub97c \uc81c\uac70\ud558\ub294 \uac83\uc774 \uc5b4\ub824\uc6b8 \uc218 \uc788\ub2e4.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\uc720\ub7fd\uc758\uc57d\ud488\uccad(EMA)\uc740 \uc18d\ubc29\ud615 \uc758\uc57d\ud488\uc5d0 \ub300\ud55c \uccb4\uc678 \uc6a9\ucd9c \uc2dc\ud5d8\uc5d0 \uad00\ud55c \uc790\uccb4 \uc9c0\uce68\uc744 \ub9c8\ub828\ud588\ub2e4[126]. \uc774 \uc6a9\ucd9c \uc9c0\uce68\uc5d0\uc11c EMA\ub294 \uc9c0\uc815\ub41c \uc2dc\uac04 \ub0b4\uc5d0 \uc6a9\ucd9c\ub418\ub294 \uc720\ud6a8 \uc131\ubd84\uc758 \uc591\uc5d0 \ub300\ud55c \uaddc\uaca9\uc744 \uba85\uc2dc\ud558\uace0 \uc788\uc73c\uba70, \uc774\ub294 \uc81c\ud488 \ub77c\ubca8\uc5d0 \uc6d0\ub8cc\uc758\uc57d\ud488(API)\uc758 \ubc31\ubd84\uc728\ub85c \ud45c\uae30\ub41c\ub2e4. \uc774 \uc9c0\uce68\uc758 \ubaa9\uc801\uc740 \ubc30\uce58 \uac04 \uc77c\uad00\uc131\uc744 \ubcf4\uc7a5\ud558\uae30 \uc704\ud55c \uaddc\uaca9\uc744 \uc124\uc815\ud558\uace0, \uc0dd\uccb4 \ub0b4 \uc0dd\uccb4\uc774\uc6a9\ub960\uacfc \uad00\ub828\ub41c \uc7a0\uc7ac\uc801 \ubb38\uc81c\ub97c \uac15\uc870\ud558\ub294 \ub370 \uc788\ub2e4. \uc720\ub7fd \uc57d\uc804(Ph. Eur. 5.17.1)\uc758 \uace0\ud615 \uc989\uc2dc\ubc29\ucd9c(IR) \uc758\uc57d\ud488\uc5d0 \ub300\ud55c \uc9c0\uce68\uc740 FDA \uaddc\uaca9\uacfc \uba87 \uac00\uc9c0 \ucc28\uc774\uc810\uc744 \ubcf4\uc778\ub2e4. \uc57d\ud559\uc801 \uad00\uc810\uc5d0\uc11c, \uc720\ub7fd \uc57d\uc804(Ph. Eur.)\uc740 IR \uc81c\ud615\uc774 \uc77c\ubc18\uc801\uc73c\ub85c 45\ubd84 \uc774\ub0b4\uc5d0 \uc6d0\ub8cc\uc57d\ubb3c\uc758 \ucd5c\uc18c 80%\uac00 \uccb4\uc678 \uc6a9\ucd9c\ub418\uc5b4\uc57c \ud55c\ub2e4\uace0 \uba85\uc2dc\ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4. \uadf8\ub7ec\ub098 USP \uc9c0\uce68\uc5d0 \ub530\ub974\uba74, \uc77c\ubc18\uc801\uc73c\ub85c 30~45\ubd84 \uc774\ub0b4\uc5d0 85% \uc774\uc0c1\uc758 \uc6d0\ub8cc\uac00 \ubc29\ucd9c\ub418\uc5b4\uc57c \ud55c\ub2e4.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">SGC\uc758 \uc6a9\ucd9c \uc2dc\ud5d8 \ubc29\ubc95\uc5d0\uc11c\ub294 \uc6a9\ucd9c \uc131\ub2a5\uc5d0 \uc601\ud5a5\uc744 \ubbf8\uce58\ub294 \ub178\ud654\uc5d0 \ub530\ub978 \uc824\ub77c\ud2f4 \uac00\uad50 \ud604\uc0c1\uc744 \ubc18\ub4dc\uc2dc \uace0\ub824\ud574\uc57c \ud569\ub2c8\ub2e4. USP\ub294 \uac00\uad50 \ud604\uc0c1\uc774 \ud655\uc778\ub420 \uacbd\uc6b0 \uacbd\uc9c8 \uc815\uc81c\uc640 SGC\uc5d0 \ub300\ud574 2\ub2e8\uacc4 \ud3c9\uac00 \ubc29\uc2dd\uc744 \ud5c8\uc6a9\ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4. \uac00\uad50 \ud604\uc0c1\uc740 \uc77c\ubc18\uc801\uc73c\ub85c \uc6a9\ucd9c \uc2dc\ud5d8 \uc218\ud589 \uc911 \uc721\uc548 \uad00\ucc30\uc744 \ud1b5\ud574 \ud655\uc778\ub429\ub2c8\ub2e4. \uc774\ub294 \uc6a9\ucd9c \ubc0f \uc2dd\uc774 \ubcf4\ucda9\uc81c\uc758 \ubd84\ud574 \ubc0f \uc6a9\ucd9c\uc5d0 \uad00\ud55c USP \uc77c\ubc18 \uc7a5\uc5d0\uc11c, \uacbd\uc9c8 \ub610\ub294 SGC \ubc0f \uc824\ub77c\ud2f4 \ucf54\ud305 \uc815\uc81c\uac00 \uc6a9\ucd9c \uc0ac\uc591\uc744 \uc900\uc218\ud558\uc9c0 \uc54a\uac70\ub098 \uc7a0\uc7ac\uc801\uc778 \uac00\uad50 \ubb38\uc81c\ub97c \ud574\uacb0\ud558\uae30 \uc704\ud574 \uc6a9\ucd9c \ub9e4\uccb4\uc758 pH\uc5d0 \ub530\ub77c \ub2e4\uc591\ud55c \ud6a8\uc18c\ub97c \ucca8\uac00\ud558\ub294 \uac83\uc744 \ud5c8\uc6a9\ud558\uace0 \uc788\ub2e4\ub294 \uc0ac\uc2e4\uc5d0 \uadfc\uac70\ud569\ub2c8\ub2e4 [127]. \uac00\uad50 \ud604\uc0c1\uc758 \uc99d\uac70\ub294 \uc6a9\ud574\ub3c4\uac00 \ub0ae\uc740 \uc824\ub77c\ud2f4 \uc258\uc774\ub098 \ud3a0\ub9ac\ud074 \ud615\uc131\uc758 \ud615\ud0dc\ub85c \ub098\ud0c0\ub0a0 \uc218 \uc788\uc73c\uba70, \uc774\ub294 \uc258\uc774 \uc6a9\ud574\ub41c \ud6c4 \ucda9\uc804\uc7ac\ub97c \ub458\ub7ec\uc2f8\uace0 \ud3ec\ud568\ud558\ub294 \uc8fc\uba38\ub2c8 \ubaa8\uc591\uc73c\ub85c \ub098\ud0c0\ub0a9\ub2c8\ub2e4(8\uc808 \ucc38\uc870). \uac00\uad50 \ud604\uc0c1\uc744 \uadf9\ubcf5\ud558\uae30 \uc704\ud574, 2\ub2e8\uacc4 \uc6a9\ucd9c \uc2dc\ud5d8\uc5d0\uc11c\ub294 \ud3a9\uc2e0, \ud30c\ud30c\uc778, \ube0c\ub85c\uba5c\ub77c\uc778 \ub610\ub294 \ud310\ud06c\ub808\uc544\ud2f4\uacfc \uac19\uc740 \ub2e8\ubc31\uc9c8 \ubd84\ud574 \ud6a8\uc18c\ub97c \uc6a9\ucd9c \ub9e4\uccb4\uc5d0 \ucca8\uac00\ud558\uace0 \uc6a9\ucd9c\uc744 \ubc18\ubcf5\ud569\ub2c8\ub2e4 [128]. \uc774\ub7ec\ud55c \ud6a8\uc18c\ub294 \uaecd\uc9c8 \ub0b4 \uc824\ub77c\ud2f4 \uac00\ub2e5\uc744 \uad6c\uc131\ud558\ub294 \uc544\ubbf8\ub178\uc0b0 \uc0ac\uc774\uc758 \ud3a9\ud0c0\uc774\ub4dc \uacb0\ud569\uc744 \ud6a8\uacfc\uc801\uc73c\ub85c \ubd84\ud574\ud569\ub2c8\ub2e4. \ud6a8\uc18c\ub97c \uc774\uc6a9\ud55c \uc6a9\ud574 \uc2dc\ud5d8\uc740 \uc8fc\uc758\ud574\uc11c \uc218\ud589\ud574\uc57c \ud569\ub2c8\ub2e4. \ud6a8\uc18c\ub294 \uc6a9\uc561\uc5d0 \ub179\uae30 \uc704\ud574 \uc0c1\ub2f9\ud55c \uae30\uacc4\uc801 \uad50\ubc18\uc774 \ud544\uc694\ud558\uace0, \uc6a9\uc561 \ub0b4 \uc548\uc815\uc131\uc774 \ub0ae\uc73c\uba70, \uacc4\uba74\ud65c\uc131\uc81c\uc640 \uac19\uc740 \uc6a9\ub9e4\uc758 \ub2e4\ub978 \uc131\ubd84\uc5d0 \uc758\ud574 \uc601\ud5a5\uc744 \ubc1b\uc744 \uc218 \uc788\uae30 \ub54c\ubb38\uc785\ub2c8\ub2e4. \uc6a9\ub9e4\uc5d0 \ub2e8\ubc31\uc9c8 \ubcc0\uc131 \uacc4\uba74\ud65c\uc131\uc81c[129]\ub97c \uc0ac\uc6a9\ud558\ub294 \uacbd\uc6b0, 2\ub2e8\uacc4 2\ub2e8\uacc4(tier 2) \ubc29\ubc95\uc744 \uc218\ud589\ud574\uc57c \ud55c\ub2e4. \uccab \ubc88\uc9f8 \ub2e8\uacc4\ub294 \uc804\ucc98\ub9ac \ub2e8\uacc4\ub85c\uc11c, \uacc4\uba74\ud65c\uc131\uc81c\uac00 \ud3ec\ud568\ub418\uc9c0 \uc54a\uc740 \ud6a8\uc18c \ud568\uc720 \uc6a9\ub9e4\ub97c \uc0ac\uc6a9\ud558\uc5ec \ucea1\uc290 \uaecd\uc9c8\uc744 \uc6a9\ud574\uc2dc\ud0a4\ub294 \uac83\uc774\ub2e4. \ucea1\uc290 \uc258\uc774 \uc6a9\ud574\ub41c \ud6c4, \uacc4\uba74\ud65c\uc131\uc81c\uac00 \ud3ec\ud568\ub41c \ubc30\uc9c0\ub97c \ucca8\uac00\ud558\uc5ec \ucda9\uc804\uc7ac\uc640 \ud65c\uc131 \uc81c\uc57d \uc131\ubd84\uc758 \uc6a9\ud574 \ubc0f \uac00\uc6a9\ud654\ub97c \uc644\ub8cc\ud569\ub2c8\ub2e4. \uc6a9\ud574 \uc5f0\uad6c\ub97c \uc218\ud589\ud558\ub294 \ub3d9\uc548 \uc18c\ud654 \ud6a8\uc18c\ub97c \uc0ac\uc6a9\ud558\uace0 \uadf8 \ud6c4\uc5d0 \uacc4\uba74\ud65c\uc131\uc81c\ub97c \uc0ac\uc6a9\ud558\ub294 \uac83\uc774 2\ub2e8\uacc4 \ubc29\ubc95\uc5d0\uc11c \ub354 \ub098\uc740 \ud6a8\uacfc\ub97c \ubcf4\uc778\ub2e4\ub294 \uac83\uc774 \uad00\ucc30\ub418\uc5c8\uc2b5\ub2c8\ub2e4 [130].<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">SGC\uc758 \uc6a9\ucd9c\uacfc \uad00\ub828\ud558\uc5ec \ub17c\uc758\ud560 \uac00\uce58\uac00 \uc788\ub294 \ub610 \ub2e4\ub978 \uc911\uc694\ud55c \uce21\uba74\uc740 \uccb4\uc678-\uccb4\ub0b4 \uc0c1\uad00\uad00\uacc4(IVIVC)\ub77c\ub294 \uac1c\ub150\uc785\ub2c8\ub2e4. \uc774\ub294 \uc77c\ubc18\uc801\uc73c\ub85c \uccb4\ub0b4 \ubc18\uc751(\uc608: \ud761\uc218\ub41c \uc57d\ubb3c\uc758 \uc591)\uacfc \uc81c\ud615\uc758 \uccb4\uc678 \ubb3c\ub9ac\ud654\ud559\uc801 \ud2b9\uc131 \uac04\uc758 \uad00\uacc4\ub97c \ud655\ub9bd\ud558\ub294 \ub370 \uc0ac\uc6a9\ub429\ub2c8\ub2e4. \uc774 \uac1c\ub150\uc758 \uc8fc\ub41c \ubaa9\uc801\uc740 \ub3d9\uc77c\ud55c \uc758\uc57d\ud488\uc758 \ub450 \uac1c \uc774\uc0c1\uc758 \ubc30\uce58\uc5d0 \ub300\ud55c \uccb4\uc678\uc801 \ud2b9\uc131\uc774 \uc0dd\uccb4 \ub0b4 \uc870\uac74\uc5d0\uc11c \uc720\uc0ac\ud558\uac8c \ub098\ud0c0\ub098\ub294\uc9c0 \ud655\uc778\ud558\ub294 \uac83\uc774\ub2e4. \ub530\ub77c\uc11c \uc774 \uad00\uacc4\ub294 \uc0dd\uccb4 \ub0b4 \uc57d\ubb3c \ubc29\ucd9c\uc744 \ubaa8\ubc29\ud558\ub3c4\ub85d \uc124\uacc4\ub41c \uc2e0\uc57d \uac1c\ubc1c \ubc0f \uc2b9\uc778 \uc808\ucc28\ub97c \uc548\ub0b4\ud558\ub294 \ub370 \uc788\uc5b4 \ubcf8\uc9c8\uc801\uc73c\ub85c \uc911\uc694\ud558\ub2e4. SGC\uc758 IVIVC\uc5d0 \ub300\ud55c \ub2e4\uc591\ud55c \uc5f0\uad6c\uac00 \uc788\uc5c8\uc73c\uba70, \uc77c\ubd80 \uc5f0\uad6c\uc5d0\uc11c\ub294 \uc591\ud638\ud55c \uc0c1\uad00\uad00\uacc4\uac00 \ub098\ud0c0\ub0ac\uc2b5\ub2c8\ub2e4. Meyer \ub4f1[53]\uc740 \uc824\ub77c\ud2f4 \uac00\uad50\ub85c \uc778\ud55c \uacbd\uc9c8 \ubc0f \uc5f0\uc9c8 \uc544\uc138\ud2b8\uc544\ubbf8\ub178\ud39c \uc824\ub77c\ud2f4 \ucea1\uc290\uc758 \uccb4\uc678 \uc6a9\ucd9c \ubcc0\ud654\uac00 \uc0dd\uccb4 \ub0b4 \uc870\uac74\uc5d0\uc11c \ucea1\uc290\uc758 \uc0dd\uccb4 \uc774\uc6a9\ub960 \ubcc0\ud654\ub97c \uc608\uce21\ud560 \uc218 \uc788\ub294\uc9c0 \ud3c9\uac00\ud588\uc2b5\ub2c8\ub2e4. \uadf8\ub4e4\uc758 \ub370\uc774\ud130\uc5d0 \ub530\ub974\uba74, \uac00\uad50\ub85c \uc778\ud574 \uacbd\uc9c8 \ubc0f SGC\uc758 \uccb4\uc678 \uc6a9\ucd9c \uc18d\ub3c4\uac00 \uac10\uc18c\ud55c \uac83\uc73c\ub85c \ub098\ud0c0\ub0ac\uc2b5\ub2c8\ub2e4. \ubc18\uba74, \uc0dd\ubb3c\ud559\uc801 \ub3d9\ub4f1\uc131 \uc5f0\uad6c\uc5d0 \ub530\ub974\uba74 \ubb3c\uc5d0\uc11c USP \uc6a9\ucd9c \uaddc\uaca9\uc744 \ucda9\uc871\ud558\uc9c0 \ubabb\ud588\uc9c0\ub9cc \ud3a9\uc2e0\uc744 \ud568\uc720\ud55c SGF\uc5d0\uc11c \uc2dc\ud5d8\ud588\uc744 \ub54c \uaddc\uaca9\uc744 \ucda9\uc871\ud55c \uacbd\uc9c8 \ubc0f SGC \ubaa8\ub450, \ubb34\ubd80\ud558 \ub300\uc870\uad70 \ucea1\uc290\uacfc \uc0dd\ubb3c\ud559\uc801 \ub3d9\ub4f1\uc131\uc774 \uc788\ub294 \uac83\uc73c\ub85c \ub098\ud0c0\ub0ac\uc2b5\ub2c8\ub2e4. \ud608\uc7a5 \ub18d\ub3c4 \ub9e4\uac1c\ubcc0\uc218\ub97c \ubc14\ud0d5\uc73c\ub85c \ubcfc \ub54c, \uac00\uad50 \uacb0\ud569 \uc815\ub3c4\uac00 \uac00\uc7a5 \ub192\uc740 \ucea1\uc290\uc740 \ube44\uac00\uad50 \ub300\uc870\uad70 \ucea1\uc290\uacfc \uc0dd\ubb3c\ud559\uc801 \ub3d9\ub4f1\uc131\uc774 \uc5c6\ub294 \uac83\uc73c\ub85c \ub098\ud0c0\ub0ac\uc2b5\ub2c8\ub2e4. \ub610 \ub2e4\ub978 \uc5f0\uad6c\uc5d0\uc11c Nishimura \ub4f1[131]\uc740 \ub09c\uc6a9\uc131 \uc57d\ubb3c\uc778 \uc544\ub8ec\ub518\uc0b0\uc744 \ud568\uc720\ud55c SGC\uc758 \uc778\uccb4 \ud608\uc7a5 \uc57d\ubb3c \ub18d\ub3c4\ub97c \uc608\uce21\ud558\uace0\uc790 \uc2dc\ub3c4\ud588\uc2b5\ub2c8\ub2e4. SGC\ub97c \ub2e8\uae30 \ubc0f \uc7a5\uae30 \uc870\uac74, \uc989 15\u00b0C\uc5d0\uc11c 3\uac1c\uc6d4, 25\u00b0C(60% \uc0c1\ub300\uc2b5\ub3c4(RH))\uc5d0\uc11c 30\uac1c\uc6d4 \ub3d9\uc548 \uac01\uac01 \ubcf4\uad00\ud588\ub2e4. \uc800\uc790\ub4e4\uc740 \uacc4\uba74\ud65c\uc131\uc81c(\uc989, 2% SLS, pH 6.8)\ub97c \ud568\uc720\ud55c \uc6a9\ucd9c \ub9e4\uccb4\ub97c \uc0ac\uc6a9\ud558\uc5ec \uc5bb\uc740 \uccb4\uc678 \uc6a9\ucd9c \ub370\uc774\ud130\uac00 \ub450 \uc800\uc7a5 \uc870\uac74 \ubaa8\ub450\uc5d0\uc11c SGC \uacbd\uad6c \ud22c\uc5ec \ud6c4\uc758 \ud608\uc7a5 \uc57d\ubb3c \ub18d\ub3c4\ub97c \uc608\uce21\ud558\ub294 \ub370 \ub354 \ud6a8\uacfc\uc801\uc784\uc744 \ubcf4\uc5ec\uc8fc\uc5c8\ub2e4. \ub9c8\ucc2c\uac00\uc9c0\ub85c, Rossi \ub4f1[132]\uc740 \uc778\uccb4 \uc0dd\uccb4 \ub0b4 \uc57d\ub3d9\ud559 \ub370\uc774\ud130\ub97c \uae30\ubc18\uc73c\ub85c \ub9ac\ud1a0\ub098\ube44\ub974 SGC\uc5d0 \ub300\ud55c \uc6a9\ucd9c \uc2dc\ud5d8\uc744 \uac1c\ubc1c\ud558\uace0 \uac80\uc99d\ud588\uc2b5\ub2c8\ub2e4. \uc800\uc790\ub4e4\uc740 25rpm\uc758 \ud68c\uc804 \uc18d\ub3c4\uc5d0\uc11c 0.3%, 0.5%, 0.7% \ub610\ub294 1%(w\/v)\uc758 SLS\ub97c \ud568\uc720\ud55c 900mL\uc758 \uc6a9\ucd9c \uc6a9\ub9e4\ub97c \uc0ac\uc6a9\ud558\ub294 USP II \ubc29\ubc95\uc744 \uc0ac\uc6a9\ud588\uc2b5\ub2c8\ub2e4. \uadf8\ub4e4\uc758 \ub370\uc774\ud130\ub294 \uc6a9\ud574\ub41c \uc57d\ubb3c\uc758 \ubc31\ubd84\uc728\uacfc \ud761\uc218\ub41c \uc57d\ubb3c\uc758 \ubc31\ubd84\uc728 \uc0ac\uc774\uc5d0 \uac15\ub825\ud55c \ub808\ubca8 A \uc0c1\uad00\uad00\uacc4\ub97c \ubcf4\uc5ec\uc8fc\uc5c8\ub2e4. 0.7% SLS\uac00 \ud3ec\ud568\ub41c \ubb3c\uc744 \uc6a9\ud574 \ub9e4\uccb4\ub85c \uc0ac\uc6a9\ud558\uc5ec \uc720\uc758\ubbf8\ud55c \uccb4\uc678-\uc0dd\uccb4 \ub0b4 \uc0c1\uad00\uad00\uacc4\ub97c \ub2ec\uc131\ud588\ub2e4. \ub610 \ub2e4\ub978 \uc720\uc0ac\ud55c \uc5f0\uad6c\uc5d0\uc11c, Donato \ub4f1[133]\uc740 \uc0dd\uccb4 \ub0b4 \ub370\uc774\ud130\ub97c \uae30\ubc18\uc73c\ub85c, \uc218\uc6a9\uc131\uc774 \ub0ae\uc740 \uc57d\ubb3c\uc778 \ub85c\ud53c\ub098\ube44\ub974\uc758 \uc5f0\uc9c8 \ucea1\uc290\uc5d0 \ub300\ud55c \uc6a9\ucd9c \uc2dc\ud5d8\uc758 \uac1c\ubc1c \ubc0f \uac80\uc99d\uc5d0 \ub300\ud574 \uc720\uc0ac\ud55c \uacb0\uacfc\ub97c \ubcf4\uace0\ud588\ub2e4. \uc774 \uc5f0\uad6c\uc5d0\uc11c\ub294 \uc0c8\ub85c\uc6b4 \ub85c\ud53c\ub098\ube44\ub974 \uc81c\ud615\uc744 \uac1c\ubc1c\ud558\uace0 \uc0dd\uccb4 \ub0b4 \ub370\uc774\ud130\ub97c \uc0ac\uc6a9\ud558\uc5ec \uadf8 \uc6a9\ucd9c \uc2dc\ud5d8\uc744 \uac80\uc99d\ud588\ub2e4. \ubaa8\ub4e0 \uc81c\ud615\uc740 pH 6.0, 25 rpm \uc870\uac74\uc5d0\uc11c 2.3% SLS\ub97c \ud568\uc720\ud55c \uc6a9\ucd9c\uc561\uc73c\ub85c \uccb4\uc678 \uc6a9\ucd9c \ud3c9\uac00\ub97c \uac70\ucce4\ub2e4. \uc774\ub7ec\ud55c \uc870\uac74\uc5d0\uc11c \uc800\uc790\ub4e4\uc740 \uc6a9\ucd9c \ubd84\uc728\uacfc \ud761\uc218 \ubd84\uc728 \uac04\uc5d0 \uac15\ub825\ud55c \ub808\ubca8 A \uc0c1\uad00\uad00\uacc4\ub97c \ubcf4\uc5ec\uc8fc\uc5c8\ub2e4.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\uc774 \uadf8\ub8f9\uc740 ~ \ubd84\uc57c\uc5d0\uc11c \uc218\ub9ce\uc740 \ud2b9\ud5c8\ub97c \ubcf4\uc720\ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4&nbsp;<a href=\"https:\/\/www.materialstests.com\/ko\/products\/gelatin-capsule-hardness-tester.html\/\">\uc824\ub77c\ud2f4 \ucea1\uc290 \uacbd\ub3c4 \uc2dc\ud5d8\uae30<\/a>,<a href=\"https:\/\/www.materialstests.com\/ko\/products\/gelatin-capsule-hardness-tester.html\/\">\uc790\ub3d9 \ucea1\uc290 \uacbd\ub3c4 \uc2dc\ud5d8\uae30<\/a>,<a href=\"https:\/\/www.materialstests.com\/ko\/medical-device-tester.html\/\">\uc758\ub8cc \uae30\uae30 \ud14c\uc2a4\ud130<\/a>,<a href=\"https:\/\/www.materialstests.com\/ko\/medical-device-tester.html\/\">\uc758\ub8cc \uc81c\ud488 \ud14c\uc2a4\ud2b8 \uae30\uae30 \uc81c\uc870\uc5c5\uccb4<\/a>,<a href=\"https:\/\/www.materialstests.com\/ko\/products\/motorized-cap-torque-tester.html\/\">\uc804\ub3d9 \ucea1 \ud1a0\ud06c \ud14c\uc2a4\ud130<\/a>,<a href=\"https:\/\/www.materialstests.com\/ko\/container-tester.html\/\">\ucee8\ud14c\uc774\ub108 \ud14c\uc2a4\ud130<\/a>,<a href=\"https:\/\/www.materialstests.com\/ko\/products\/fabric-thickness-tester.html\/\">\uc6d0\ub2e8 \ub450\uaed8 \ud14c\uc2a4\ud130<\/a>,<a href=\"https:\/\/www.materialstests.com\/ko\/products\/digital-test-stand.html\/\">\ub514\uc9c0\ud138 \ud14c\uc2a4\ud2b8 \uc2a4\ud0e0\ub4dc<\/a>,<a href=\"https:\/\/www.materialstests.com\/ko\/products\/vertical-tensile-tester.html\/\">\uc218\uc9c1 \uc778\uc7a5 \uc2dc\ud5d8\uae30<\/a>, \uc5d4\uc9c0\ub2c8\uc5b4 \uc591\uc131\uacfc \uc2e0\uc18d\ud55c \uc0ac\ud6c4 \uc11c\ube44\uc2a4\ub97c \ubc14\ud0d5\uc73c\ub85c, \ub2f9\uc0ac\ub294 \uc5c5\uacc4\uc5d0\uc11c \uc120\ub3c4\uc801\uc778 \uc785\uc9c0\ub97c \ud655\uace0\ud788 \ub2e4\uc84c\uc2b5\ub2c8\ub2e4.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\uc774 \uc81c\ud488\uc5d0 \ub300\ud55c \uc790\uc138\ud55c \uc815\ubcf4\uac00 \ud544\uc694\ud558\uc2dc\uba74 \uc5b8\uc81c\ub4e0\uc9c0 \ubb38\uc758\ud574 \uc8fc\uc138\uc694. \ub2e4\ub978 \uc778\uae30 \uc81c\ud488\uc744 \ucd94\ucc9c\ud574 \uc8fc\uc138\uc694:&nbsp;<a href=\"https:\/\/www.materialstests.com\/ko\/resources\/automatic-capsule-hardness-tester.html\/\">\ucea1\uc290 \uacbd\ub3c4 \uc2dc\ud5d8\uae30<\/a><br><\/p>","protected":false},"excerpt":{"rendered":"<p>\uc18c\ud504\ud2b8\uc824 \ucea1\uc290 \uacbd\ub3c4 \uc2dc\ud5d8\uae30\ub780 \ubb34\uc5c7\uc778\uac00\uc694? \uc18c\ud504\ud2b8 \uc824\ub77c\ud2f4 \ucea1\uc290\uc740 \ud3ec\uc7a5 \uc804\uc5d0 \ud0c4\uc131 \ud14c\uc2a4\ud2b8\ub97c \uac70\uccd0\uc57c \ud569\ub2c8\ub2e4. \uc774\ub54c\ub294 \uc77c\ubc18 \ud14c\uc2a4\ud130\uac00 \uc544\ub2cc \ud14c\uc2a4\ud130\uac00 \ud544\uc694\ud569\ub2c8\ub2e4. \ucea1\uc290 \uc81c\uc870\uc5c5\uccb4\ub294 \uc81c\ud488\uc744 \uc18c\ube44\uc790\uc5d0\uac8c \ucd9c\uc2dc\ud558\uae30 \uc804\uc5d0 \uc81c\ud488\uc774 \uc124\uc815\ub41c \uc0b0\uc5c5 \ud45c\uc900 \ud488\uc9c8\uc744 \ud1b5\uacfc\ud588\ub294\uc9c0 \ud655\uc778\ud558\uae30 \uc704\ud574 \uc2e0\ub8b0\ud560 \uc218\uc788\ub294\uc18c\ud504\ud2b8 \uc824 \ucea1\uc290 \uacbd\ub3c4 \uc2dc\ud5d8\uae30...<\/p>","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-1022","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.materialstests.com\/ko\/wp-json\/wp\/v2\/posts\/1022","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.materialstests.com\/ko\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.materialstests.com\/ko\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.materialstests.com\/ko\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.materialstests.com\/ko\/wp-json\/wp\/v2\/comments?post=1022"}],"version-history":[{"count":0,"href":"https:\/\/www.materialstests.com\/ko\/wp-json\/wp\/v2\/posts\/1022\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.materialstests.com\/ko\/wp-json\/wp\/v2\/media?parent=1022"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.materialstests.com\/ko\/wp-json\/wp\/v2\/categories?post=1022"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.materialstests.com\/ko\/wp-json\/wp\/v2\/tags?post=1022"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}